Prokineticin receptor 2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Prokineticin receptor 2''' ('''PKR<sub>2</sub>'''), is a [[G protein-coupled receptor]] encoded by the '''PROKR2''' [[gene]] in humans.<ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prokineticin receptor 2
| HGNCid = 15836
| Symbol = PROKR2
| AltSymbols =; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3
| OMIM = 607123
| ECnumber = 
| Homologene = 16368
| MGIid = 2181363
| GeneAtlas_image1 = PBB_GE_PROKR2_gnf1h10315_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004983 |text = neuropeptide Y receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 128674
    | Hs_Ensembl = ENSG00000101292
    | Hs_RefseqProtein = NP_658986
    | Hs_RefseqmRNA = NM_144773
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 5230686
    | Hs_GenLoc_end = 5243015
    | Hs_Uniprot = Q8NFJ6
    | Mm_EntrezGene = 246313
    | Mm_Ensembl = ENSMUSG00000050558
    | Mm_RefseqmRNA = NM_144944
    | Mm_RefseqProtein = NP_659193
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 132062606
    | Mm_GenLoc_end = 132076841
    | Mm_Uniprot = Q6GTF8
  }}
}}
'''Prokineticin receptor 2''', also known as '''PROKR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PROKR2 prokineticin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128674| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.<ref name="entrez">{{cite web | title = Entrez Gene: PROKR2 prokineticin receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128674| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.<ref name="entrez">{{cite web | title = Entrez Gene: PROKR2 prokineticin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128674| accessdate = }}</ref>
}}


==See also==
[[Mutation]]s in the ''PROKR2'' (also known as ''KAL3'') [[gene]] have been implicated in [[hypogonadotropic hypogonadism]] and [[gynecomastia]].<ref name="NarulaCarlson2014">{{cite journal | vauthors = Narula HS, Carlson HE | title = Gynaecomastia--pathophysiology, diagnosis and treatment | journal = Nature Reviews. Endocrinology | volume = 10 | issue = 11 | pages = 684–98 | date = November 2014 | pmid = 25112235 | doi = 10.1038/nrendo.2014.139 }}</ref>
 
== See also ==
* [[Prokineticin receptor]]
* [[Prokineticin receptor]]
* [[Kallmann syndrome]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{clear}}
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY | title = Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19276–80 | date = May 2002 | pmid = 11886876 | doi = 10.1074/jbc.M202139200 | url = http://www.jbc.org/content/277/22/19276.full.pdf }}
* {{cite journal | vauthors = Soga T, ((Matsumoto Si)), Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K | title = Molecular cloning and characterization of prokineticin receptors | journal = Biochimica et Biophysica Acta | volume = 1579 | issue = 2-3 | pages = 173–9 | date = December 2002 | pmid = 12427552 | doi = 10.1016/S0167-4781(02)00546-8 }}
* {{cite journal | vauthors = Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN | title = Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 5 | pages = 2463–9 | date = May 2004 | pmid = 15126578 | doi = 10.1210/jc.2003-032012 }}
* {{cite journal | vauthors = Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA | title = The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy | journal = Endocrinology | volume = 147 | issue = 9 | pages = 4245–51 | date = September 2006 | pmid = 16763065 | doi = 10.1210/en.2006-0614 }}
* {{cite journal | vauthors = Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP | title = Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2 | journal = PLoS Genetics | volume = 2 | issue = 10 | pages = e175 | date = October 2006 | pmid = 17054399 | pmc = 1617130 | doi = 10.1371/journal.pgen.0020175 }}
{{refend}}


==Further reading==
== External links ==
{{refbegin | 2}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=kms GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome]
{{PBB_Further_reading
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3017 | title = Prokineticin Receptors: PKR<sub>2</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
| citations =  
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Lin DC, Bullock CM, Ehlert FJ, ''et al.'' |title=Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19276-80 |year= 2002 |pmid= 11886876 |doi= 10.1074/jbc.M202139200 }}
*{{cite journal  | author=Soga T, Matsumoto S, Oda T, ''et al.'' |title=Molecular cloning and characterization of prokineticin receptors. |journal=Biochim. Biophys. Acta |volume=1579 |issue= 2-3 |pages= 173-9 |year= 2003 |pmid= 12427552 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Battersby S, Critchley HO, Morgan K, ''et al.'' |title=Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 5 |pages= 2463-9 |year= 2004 |pmid= 15126578 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Pasquali D, Rossi V, Staibano S, ''et al.'' |title=The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. |journal=Endocrinology |volume=147 |issue= 9 |pages= 4245-51 |year= 2006 |pmid= 16763065 |doi= 10.1210/en.2006-0614 }}
*{{cite journal  | author=Dodé C, Teixeira L, Levilliers J, ''et al.'' |title=Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. |journal=PLoS Genet. |volume=2 |issue= 10 |pages= e175 |year= 2006 |pmid= 17054399 |doi= 10.1371/journal.pgen.0020175 }}
}}
{{refend}}


{{membrane-protein-stub}}
{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]

Latest revision as of 07:15, 10 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Prokineticin receptor 2 (PKR2), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[1]

Function

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: PROKR2 prokineticin receptor 2".
  2. ↑ Narula HS, Carlson HE (November 2014). "Gynaecomastia--pathophysiology, diagnosis and treatment". Nature Reviews. Endocrinology. 10 (11): 684–98. doi:10.1038/nrendo.2014.139. PMID 25112235.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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