Methylpentynol: Difference between revisions

	WikiDoc Resources for Methylpentynol
Articles
Most recent articles on Methylpentynol Most cited articles on Methylpentynol Review articles on Methylpentynol Articles on Methylpentynol in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Methylpentynol Images of Methylpentynol Photos of Methylpentynol Podcasts & MP3s on Methylpentynol Videos on Methylpentynol
Evidence Based Medicine
Cochrane Collaboration on Methylpentynol Bandolier on Methylpentynol TRIP on Methylpentynol
Clinical Trials
Ongoing Trials on Methylpentynol at Clinical Trials.gov Trial results on Methylpentynol Clinical Trials on Methylpentynol at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Methylpentynol NICE Guidance on Methylpentynol NHS PRODIGY Guidance FDA on Methylpentynol CDC on Methylpentynol
Books
Books on Methylpentynol
News
Methylpentynol in the news Be alerted to news on Methylpentynol News trends on Methylpentynol
Commentary
Blogs on Methylpentynol
Definitions
Definitions of Methylpentynol
Patient Resources / Community
Patient resources on Methylpentynol Discussion groups on Methylpentynol Patient Handouts on Methylpentynol Directions to Hospitals Treating Methylpentynol Risk calculators and risk factors for Methylpentynol
Healthcare Provider Resources
Symptoms of Methylpentynol Causes & Risk Factors for Methylpentynol Diagnostic studies for Methylpentynol Treatment of Methylpentynol
Continuing Medical Education (CME)
CME Programs on Methylpentynol
International
Methylpentynol en Espanol Methylpentynol en Francais
Business
Methylpentynol in the Marketplace Patents on Methylpentynol
Experimental / Informatics
List of terms related to Methylpentynol

Methylpentynol
Clinical data
Trade names	Oblivon
ATC code	N05CM15 (WHO) ;
Identifiers
	IUPAC name 3-methylpent-1-yn-3-ol;
CAS Number	77-75-8 ;
PubChem CID	6494;
ChemSpider	21106516 ;
UNII	B017BC5B1N;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C6H10O
Molar mass	98.143 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCC(C)(C#C)O;
	InChI InChI=1S/C6H10O/c1-4-6(3,7)5-2/h1,7H,5H2,2-3H3 ; Key:QXLPXWSKPNOQLE-UHFFFAOYSA-N ;
(what is this?) (verify)

VisualWikitext

Latest revision as of 16:42, 20 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Methylpentynol (Methylparafynol, Dormison, Atemorin) is a tertiary hexanol with hypnotic/sedative and anticonvulsant effects. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles. To make meparfynol proper, the alcohol must be reacted with phosgene followed by ammonia to form the carbamate (see patent). Also, ethynylation of cyclohexanone is one of the preferred analogs

References

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        = 3-methylpent-1-yn-3-ol
+| Verifiedfields = changed
-| image             = Methylpentynol.png
+| Watchedfields = changed
-| CAS_number        = 77-75-8
+| verifiedrevid = 447908931
-| ATC_prefix        = N05
+| IUPAC_name = 3-methylpent-1-yn-3-ol
-| ATC_suffix        = CM15
+| image = Meparfynol.png
-| PubChem           = 6494
-| DrugBank          =
+<!--Clinical data-->
-| C=6|H=10|O=1
+| tradename =  Oblivon
-| molecular_weight  = 98.143 g/mol
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| bioavailability   =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| protein_bound     =
+| pregnancy_category =
-| metabolism        =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| elimination_half-life =
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| excretion         =
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_status =
-| pregnancy_category=
+| routes_of_administration =
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_status      =
-| routes_of_administration =
-}}
-'''Methylpentynol''' ('''Methylparafynol''', '''Dormison''', '''Atemorin''') is a [[hypnotic]]/[[sedative]] with [[anticonvulsant]] effects. It was previously used for the treatment of [[insomnia]] but has been replaced by newer drugs with better safety profiles.<ref>HIRSH HL, ORSINGER WH. Methylparafynol--a new type hypnotic. Preliminary report on its therapeutic efficacy and toxicity. ''American Practitioner and Digest of Treatment''. 1952 Jan;3(1):23-6.</ref><ref>SCHAFFARZICK RW, BROWN BJ. The anticonvulsant activity and toxicity of methylparafynol (dormison) and some other alcohols. ''Science''. 1952 Dec 12;116(3024):663-5.</ref><ref>HERZ A. A new type of hypnotic; unsaturated tertiary carbinols; experimental studies on therapeutic use of 3-methyl-pentin-ol-3 (methylparafynol). ''Arzneimittelforschung''. 1954 Mar;4(3):198-9.</ref><ref>WEAVER LC, ALEXANDER WM, ABREU BE. Anticonvulsant activity of compounds related to methylparafynol. ''Archives Internationales de Pharmacodynamie et de Therapie''. 1961 Apr 1;131:116-22.</ref>
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 77-75-8
+| ATC_prefix = N05
+| ATC_suffix = CM15
+| PubChem = 6494
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = B017BC5B1N
+| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID      = 21106516
-{{pharmacology-stub}}
+<!--Chemical data-->
+| C=6 | H=10 | O=1
+| molecular_weight = 98.143 g/mol
+| smiles            = CCC(C)(C#C)O
+| InChI             = 1/C6H10O/c1-4-6(3,7)5-2/h1,7H,5H2,2-3H3
+| InChIKey          = QXLPXWSKPNOQLE-UHFFFAOYAI
+| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChI          = 1S/C6H10O/c1-4-6(3,7)5-2/h1,7H,5H2,2-3H3
+| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChIKey       = QXLPXWSKPNOQLE-UHFFFAOYSA-N
+}}
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Methylpentynol''' ('''Methylparafynol''', '''Dormison''', '''Atemorin''') is a [[Alcohol#tertiary|tertiary]] [[hexanol]] with [[hypnotic]]/[[sedative]] and [[anticonvulsant]] effects. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of [[insomnia]], but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.
+To make meparfynol proper, the alcohol must be reacted with [[phosgene]] followed by ammonia to form the [[carbamate]] (see patent). Also, ethynylation of cyclohexanone is one of the preferred analogs
 ==References==
 {{reflist|2}}
 {{Hypnotics and sedatives}}
-{{WikiDoc Sources}}
+[[Category:Anticonvulsants]]
+[[Category:Drug]]

Methylpentynol: Difference between revisions

Latest revision as of 16:42, 20 August 2015

Overview

References

Navigation menu