Metabotropic glutamate receptor 8

Glutamate receptor, metabotropic 8
Identifiers
Symbols	GRM8 ; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 654
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, metabotropic 8, also known as GRM8, is a human gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.

See also

• Metabotropic glutamate receptor

Further reading

• Scherer SW, Duvoisin RM, Kuhn R; et al. (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Soder S, Duvoisin RM; et al. (1997). "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1". Genomics. 44 (2): 232–6. doi:10.1006/geno.1997.4842. PMID 9299241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu S, Wright RA, Rockey PK; et al. (1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Res. Mol. Brain Res. 53 (1–2): 88–97. PMID 9473604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malherbe P, Kratzeisen C, Lundstrom K; et al. (1999). "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8". Brain Res. Mol. Brain Res. 67 (2): 201–10. PMID 10216218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thomas NK, Wright RA, Howson PA; et al. (2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology. 40 (3): 311–8. PMID 11166323.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. PMID 11943148.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang Z, El Far O, Betz H, Scheschonka A (2006). "Pias1 interaction and sumoylation of metabotropic glutamate receptor 8". J. Biol. Chem. 280 (46): 38153–9. doi:10.1074/jbc.M508168200. PMID 16144832.CS1 maint: Multiple names: authors list (link)
• Kobayashi Y, Akiyoshi J, Kanehisa M; et al. (2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatr. Genet. 17 (1): 9. doi:10.1097/YPG.0b013e32801118bc. PMID 17167337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.