Metabotropic glutamate receptor 7: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''Metabotropic glutamate receptor 7''' is a [[protein]] that in humans is encoded by the ''GRM7'' [[gene]].<ref name="pmid8288585">{{cite journal |vauthors=Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S | title = Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction | journal = J Biol Chem | volume = 269 | issue = 2 | pages = 1231–6 | date = February 1994 | pmid = 8288585 | pmc = | doi = }}</ref><ref name="pmid8840028">{{cite journal |vauthors=Makoff A, Pilling C, Harrington K, Emson P | title = Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS | journal = Brain Res Mol Brain Res | volume = 40 | issue = 1 | pages = 165–70 | date = January 1997 | pmid = 8840028 | pmc =  | doi = 10.1016/0169-328X(96)00110-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRM7 glutamate receptor, metabotropic 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_GRM7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e4z.
| PDB = {{PDB2|2e4z}}
| Name = Glutamate receptor, metabotropic 7
| HGNCid = 4599
| Symbol = GRM7
| AltSymbols =; GLUR7; FLJ40498; GPRC1G; MGLUR7; mGlu7
| OMIM = 604101
| ECnumber = 
| Homologene = 20233
| MGIid = 1351344
| GeneAtlas_image1 = PBB_GE_GRM7_217008_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}} {{GNF_GO|id=GO:0048787 |text = active zone presynaptic plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0042596 |text = fear response}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2917
    | Hs_Ensembl = ENSG00000196277
    | Hs_RefseqProtein = NP_000835
    | Hs_RefseqmRNA = NM_000844
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 6878076
    | Hs_GenLoc_end = 7710342
    | Hs_Uniprot = Q14831
    | Mm_EntrezGene = 108073
    | Mm_Ensembl = ENSMUSG00000056755
    | Mm_RefseqmRNA = NM_177328
    | Mm_RefseqProtein = NP_796302
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 110611645
    | Mm_GenLoc_end = 111461678
    | Mm_Uniprot = Q80T39
  }}
}}
'''Glutamate receptor, metabotropic 7''', also known as '''GRM7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM7 glutamate receptor, metabotropic 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.  Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.  Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C.  Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.  Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.  Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GRM7 glutamate receptor, metabotropic 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917| accessdate = }}</ref>
}}


==Ligands (subtype selective)==
[[L-glutamate]] is the major excitatory [[neurotransmitter]] in the central nervous system and activates both ionotropic and [[metabotropic glutamate receptor]]s.  Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.  Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.<ref name="entrez"/>
*AMN082: [[allosteric]] agonist<ref>{{cite journal |author=Li X, Gardner EL, Xi ZX |title=The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats |journal=Neuropharmacology |volume=54 |issue=3 |pages=542–51 |year=2008 |pmid=18155073 |doi=10.1016/j.neuropharm.2007.11.005 |url=}}
</ref><ref name="pmid17622518">{{cite journal |author=Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A |title=Activation of the mGlu7 receptor elicits antidepressant-like effects in mice |journal=Psychopharmacology (Berl.) |volume=194 |issue=4 |pages=555–62 |year=2007 |pmid=17622518 |doi=10.1007/s00213-007-0856-2 |url=}}
</ref>; induces rapid [[internalization]]<ref>{{cite journal |author=Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ |title=mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082 |journal=Neuropharmacology |volume=52 |issue=1 |pages=108–17 |year=2007 |pmid=16914173 |doi=10.1016/j.neuropharm.2006.07.020 |url=}}</ref>; non-glutamatergic binding component<ref name="pmid17622518"/>
*MMPIP: allosteric antagonist/inverse agonist<ref>{{cite journal |author=Suzuki G, Tsukamoto N, Fushiki H, ''et al'' |title=In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists |journal=J. Pharmacol. Exp. Ther. |volume=323 |issue=1 |pages=147–56 |year=2007 |pmid=17609420 |doi=10.1124/jpet.107.124701 |url=}}</ref>


==References==
== Ligands ==
{{reflist|2}}


==Further reading==
=== Agonists ===
 
*[[AMN082]]: [[allosteric]] agonist;<ref>{{cite journal |vauthors=Li X, Gardner EL, Xi ZX | title = The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats | journal = Neuropharmacology | volume = 54 | issue = 3 | pages = 542–51 | year = 2008 | pmid = 18155073 | pmc = 2410088 | doi = 10.1016/j.neuropharm.2007.11.005 | url =  }}
</ref><ref name="pmid17622518">{{cite journal |vauthors=Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A | title = Activation of the mGlu7 receptor elicits antidepressant-like effects in mice | journal = Psychopharmacology | volume = 194 | issue = 4 | pages = 555–62 | year = 2007 | pmid = 17622518 | doi = 10.1007/s00213-007-0856-2 }}
</ref> induces rapid [[internalization]];<ref>{{cite journal |vauthors=Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ | title = mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082 | journal = Neuropharmacology | volume = 52 | issue = 1 | pages = 108–17 | year = 2007 | pmid = 16914173 | doi = 10.1016/j.neuropharm.2006.07.020  }}</ref> non-glutamatergic binding component<ref name="pmid17622518"/>
 
=== Antagonists ===
 
* [[MMPIP]]: allosteric antagonist/inverse agonist<ref>{{cite journal |vauthors=Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H | title = In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists | journal = J. Pharmacol. Exp. Ther. | volume = 323 | issue = 1 | pages = 147–56 | year = 2007 | pmid = 17609420 | doi = 10.1124/jpet.107.124701 }}</ref>
 
===Negative allosteric modulator===
* ADX-71743<ref name="pmid23257312">{{cite journal  |vauthors=Kalinichev M, Rouillier M, Girard F, etal |title=ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization |journal=J. Pharmacol. Exp. Ther. |volume=344 |issue=3 |pages=624–36 |year=2013 |pmid=23257312 |doi=10.1124/jpet.112.200915 |url=}}</ref>
 
== Interactions ==
 
Metabotropic glutamate receptor 7 has been shown to [[Protein-protein interaction|interact]] with [[PICK1]].<ref name=pmid11007882>{{cite journal |vauthors=Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S | title = PICK1 interacts with and regulates PKC phosphorylation of mGLUR7 | language =  | journal = J. Neurosci. | volume = 20 | issue = 19 | pages = 7252–7 | date = October 2000 | pmid = 11007882  }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC | title = Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q | journal = Genomics | volume = 31 | issue = 2 | pages = 230–3 | year = 1997 | pmid = 8824806 | doi = 10.1006/geno.1996.0036 }}
| citations =
*{{cite journal |vauthors=Flor PJ, Van Der Putten H, Rüegg D, Lukic S, Leonhardt T, Bence M, Sansig G, Knöpfel T, Kuhn R | title = A novel splice variant of a metabotropic glutamate receptor, human mGluR7b | journal = Neuropharmacology | volume = 36 | issue = 2 | pages = 153–9 | year = 1997 | pmid = 9144652 | doi = 10.1016/S0028-3908(96)00176-1 }}
*{{cite journal  | author=Okamoto N, Hori S, Akazawa C, ''et al.'' |title=Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1231-6 |year= 1994 |pmid= 8288585 |doi=  }}
*{{cite journal |vauthors=Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, Johnson BG, Schoepp DD, Belagaje RM | title = Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells | journal = Brain Res. Mol. Brain Res. | volume = 53 | issue = 1–2 | pages = 88–97 | year = 1998 | pmid = 9473604 | doi = 10.1016/S0169-328X(97)00277-5 }}
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal |vauthors=Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S | title = A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7 | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27573–7 | year = 1999 | pmid = 10488094 | doi = 10.1074/jbc.274.39.27573 }}
*{{cite journal | author=Makoff A, Pilling C, Harrington K, Emson P |title=Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. |journal=Brain Res. Mol. Brain Res. |volume=40 |issue= 1 |pages= 165-70 |year= 1997 |pmid= 8840028 |doi=  }}
*{{cite journal |vauthors=O'Connor V, El Far O, Bofill-Cardona E, Nanoff C, Freissmuth M, Karschin A, Airas JM, Betz H, Boehm S | title = Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling | journal = Science | volume = 286 | issue = 5442 | pages = 1180–4 | year = 1999 | pmid = 10550060 | doi = 10.1126/science.286.5442.1180 }}
*{{cite journal  | author=Flor PJ, Van Der Putten H, Rüegg D, ''et al.'' |title=A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. |journal=Neuropharmacology |volume=36 |issue= 2 |pages= 153-9 |year= 1997 |pmid= 9144652 |doi= }}
*{{cite journal |vauthors=Barbon A, Ferraboli S, Barlati S | title = Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping | journal = Cytogenet. Cell Genet. | volume = 88 | issue = 3–4 | pages = 288 | year = 2000 | pmid = 10828612 | doi = 10.1159/000015541 }}
*{{cite journal | author=Wu S, Wright RA, Rockey PK, ''et al.'' |title=Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1-2 |pages= 88-97 |year= 1998 |pmid= 9473604 |doi= }}
*{{cite journal |vauthors=Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S | title = PICK1 interacts with and regulates PKC phosphorylation of mGLUR7 | journal = J. Neurosci. | volume = 20 | issue = 19 | pages = 7252–7 | year = 2001 | pmid = 11007882 | doi = }}
*{{cite journal | author=Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S |title=A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27573-7 |year= 1999 |pmid= 10488094 |doi= }}
*{{cite journal |vauthors=Bolonna AA, Kerwin RW, Munro J, Arranz MJ, Makoff AJ | title = Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia | journal = Schizophr. Res. | volume = 47 | issue = 1 | pages = 99–103 | year = 2001 | pmid = 11163549 | doi = 10.1016/S0920-9964(99)00235-2 }}
*{{cite journal | author=O'Connor V, El Far O, Bofill-Cardona E, ''et al.'' |title=Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. |journal=Science |volume=286 |issue= 5442 |pages= 1180-4 |year= 1999 |pmid= 10550060 |doi= }}
*{{cite journal |vauthors=Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK | title = The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15221–4 | year = 2002 | pmid = 11891216 | doi = 10.1074/jbc.C200112200 }}
*{{cite journal | author=Barbon A, Ferraboli S, Barlati S |title=Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1-->p25.2 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 288 |year= 2000 |pmid= 10828612 |doi= }}
*{{cite journal | author = Enz R | title = The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7 | journal = FEBS Lett. | volume = 514 | issue = 2–3 | pages = 184–8 | year = 2002 | pmid = 11943148 | doi = 10.1016/S0014-5793(02)02361-X }}
*{{cite journal | author=Dev KK, Nakajima Y, Kitano J, ''et al.'' |title=PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. |journal=J. Neurosci. |volume=20 |issue= 19 |pages= 7252-7 |year= 2001 |pmid= 11007882 |doi= }}
*{{cite journal |vauthors=Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ | title = Interaction between metabotropic glutamate receptor 7 and alpha tubulin | journal = J. Neurochem. | volume = 80 | issue = 6 | pages = 980–8 | year = 2002 | pmid = 11953448 | pmc = 2925652 | doi = 10.1046/j.0022-3042.2002.00778.x }}
*{{cite journal | author=Bolonna AA, Kerwin RW, Munro J, ''et al.'' |title=Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. |journal=Schizophr. Res. |volume=47 |issue= 1 |pages= 99-103 |year= 2001 |pmid= 11163549 |doi= }}
*{{cite journal |vauthors=Schulz HL, Stohr H, Weber BH | title = Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7) | journal = Neurosci. Lett. | volume = 326 | issue = 1 | pages = 37–40 | year = 2002 | pmid = 12052533 | doi = 10.1016/S0304-3940(02)00306-3 }}
*{{cite journal | author=Hirbec H, Perestenko O, Nishimune A, ''et al.'' |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221-4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200 }}
*{{cite journal |vauthors=Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, Hanada H, Kodama K, Isogawa K, Tsutsumi T | title = Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder | journal = Psychiatr. Genet. | volume = 17 | issue = 1 | pages = 9 | year = 2007 | pmid = 17167337 | doi = 10.1097/YPG.0b013e32801118bc }}
*{{cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184-8 |year= 2002 |pmid= 11943148 |doi= }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi= }}
*{{cite journal | author=Schulz HL, Stohr H, Weber BH |title=Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7). |journal=Neurosci. Lett. |volume=326 |issue= 1 |pages= 37-40 |year= 2002 |pmid= 12052533 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kobayashi Y, Akiyoshi J, Kanehisa M, ''et al.'' |title=Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 1 |pages= 9 |year= 2007 |pmid= 17167337 |doi= 10.1097/YPG.0b013e32801118bc }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{PDB Gallery|geneid=2917}}
{{G protein-coupled receptors|g3}}
{{Metabotropic glutamate receptor modulators}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
 
[[Category:G protein coupled receptors]]
[[Category:Metabotropic glutamate receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 01:06, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene.[1][2][3]

Function

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.[3]

Ligands

Agonists

Antagonists

  • MMPIP: allosteric antagonist/inverse agonist[7]

Negative allosteric modulator

Interactions

Metabotropic glutamate receptor 7 has been shown to interact with PICK1.[9]

References

  1. ↑ Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (February 1994). "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction". J Biol Chem. 269 (2): 1231–6. PMID 8288585.
  2. ↑ Makoff A, Pilling C, Harrington K, Emson P (January 1997). "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS". Brain Res Mol Brain Res. 40 (1): 165–70. doi:10.1016/0169-328X(96)00110-6. PMID 8840028.
  3. ↑ 3.0 3.1 "Entrez Gene: GRM7 glutamate receptor, metabotropic 7".
  4. ↑ Li X, Gardner EL, Xi ZX (2008). "The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats". Neuropharmacology. 54 (3): 542–51. doi:10.1016/j.neuropharm.2007.11.005. PMC 2410088. PMID 18155073.
  5. ↑ 5.0 5.1 Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). "Activation of the mGlu7 receptor elicits antidepressant-like effects in mice". Psychopharmacology. 194 (4): 555–62. doi:10.1007/s00213-007-0856-2. PMID 17622518.
  6. ↑ Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). "mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082". Neuropharmacology. 52 (1): 108–17. doi:10.1016/j.neuropharm.2006.07.020. PMID 16914173.
  7. ↑ Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". J. Pharmacol. Exp. Ther. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420.
  8. ↑ Kalinichev M, Rouillier M, Girard F, et al. (2013). "ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization". J. Pharmacol. Exp. Ther. 344 (3): 624–36. doi:10.1124/jpet.112.200915. PMID 23257312.
  9. ↑ Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882.

Further reading

  • Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806.
  • Flor PJ, Van Der Putten H, Rüegg D, Lukic S, Leonhardt T, Bence M, Sansig G, Knöpfel T, Kuhn R (1997). "A novel splice variant of a metabotropic glutamate receptor, human mGluR7b". Neuropharmacology. 36 (2): 153–9. doi:10.1016/S0028-3908(96)00176-1. PMID 9144652.
  • Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, Johnson BG, Schoepp DD, Belagaje RM (1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Res. Mol. Brain Res. 53 (1–2): 88–97. doi:10.1016/S0169-328X(97)00277-5. PMID 9473604.
  • Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). "A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7". J. Biol. Chem. 274 (39): 27573–7. doi:10.1074/jbc.274.39.27573. PMID 10488094.
  • O'Connor V, El Far O, Bofill-Cardona E, Nanoff C, Freissmuth M, Karschin A, Airas JM, Betz H, Boehm S (1999). "Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling". Science. 286 (5442): 1180–4. doi:10.1126/science.286.5442.1180. PMID 10550060.
  • Barbon A, Ferraboli S, Barlati S (2000). "Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 288. doi:10.1159/000015541. PMID 10828612.
  • Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882.
  • Bolonna AA, Kerwin RW, Munro J, Arranz MJ, Makoff AJ (2001). "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia". Schizophr. Res. 47 (1): 99–103. doi:10.1016/S0920-9964(99)00235-2. PMID 11163549.
  • Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
  • Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148.
  • Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.
  • Schulz HL, Stohr H, Weber BH (2002). "Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)". Neurosci. Lett. 326 (1): 37–40. doi:10.1016/S0304-3940(02)00306-3. PMID 12052533.
  • Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, Hanada H, Kodama K, Isogawa K, Tsutsumi T (2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatr. Genet. 17 (1): 9. doi:10.1097/YPG.0b013e32801118bc. PMID 17167337.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=Metabotropic_glutamate_receptor_7&oldid=1413110"