Metabotropic glutamate receptor 3

Glutamate receptor, metabotropic 3
File:PBB Protein GRM3 image.jpg PDB rendering based on 2e4u.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2e4u​, 2e4v​, 2e4w​, 2e4x​, 2e4y​
Identifiers
Symbols	GRM3 ; GLUR3; GPRC1C; MGLUR3; mGlu3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 651
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE GRM3 205814 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, metabotropic 3, also known as GRM3, is a human gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

See also

• Metabotropic glutamate receptor

Further reading

• Scherer SW, Duvoisin RM, Kuhn R; et al. (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Makoff A, Volpe F, Lelchuk R; et al. (1997). "Molecular characterization and localization of human metabotropic glutamate receptor type 3". Brain Res. Mol. Brain Res. 40 (1): 55–63. PMID 8840013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Emile L, Mercken L, Apiou F; et al. (1997). "Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3". Neuropharmacology. 35 (5): 523–30. PMID 8887960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corti C, Sala CF, Yang F; et al. (2001). "Genomic organization of the human metabotropic glutamate receptor subtype 3". J. Neurogenet. 14 (4): 207–25, 271. PMID 11342382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corti C, Xuereb JH, Corsi M, Ferraguti F (2001). "Identification and characterization of the promoter region of the GRM3 gene". Biochem. Biophys. Res. Commun. 286 (2): 381–7. doi:10.1006/bbrc.2001.5391. PMID 11500049.CS1 maint: Multiple names: authors list (link)
• Tomiyama M, Kimura T, Maeda T; et al. (2001). "Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis". J. Neurol. Sci. 189 (1–2): 65–9. PMID 11535235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosemond E, Peltekova V, Naples M; et al. (2002). "Molecular determinants of high affinity binding to group III metabotropic glutamate receptors". J. Biol. Chem. 277 (9): 7333–40. doi:10.1074/jbc.M110476200. PMID 11744707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martí SB, Cichon S, Propping P, Nöthen M (2002). "Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population". Am. J. Med. Genet. 114 (1): 46–50. PMID 11840505.CS1 maint: Multiple names: authors list (link)
• Kitano J, Kimura K, Yamazaki Y; et al. (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. PMID 11850456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirbec H, Perestenko O, Nishimune A; et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujii Y, Shibata H, Kikuta R; et al. (2004). "Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia". Psychiatr. Genet. 13 (2): 71–6. doi:10.1097/01.ypg.0000056682.82896.b0. PMID 12782962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aronica E, Gorter JA, Ijlst-Keizers H; et al. (2003). "Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins". Eur. J. Neurosci. 17 (10): 2106–18. PMID 12786977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flajolet M, Rakhilin S, Wang H; et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMID 14663150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao Y, Koo JC, Wells JW, Hampson DR (2004). "Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor". Biochem. Biophys. Res. Commun. 319 (2): 622–8. doi:10.1016/j.bbrc.2004.05.032. PMID 15178451.CS1 maint: Multiple names: authors list (link)
• Tang FR, Chia SC, Chen PM; et al. (2004). "Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus". Epilepsy Res. 59 (2–3): 167–80. doi:10.1016/j.eplepsyres.2004.04.002. PMID 15246118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Egan MF, Straub RE, Goldberg TE; et al. (2004). "Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12604–9. doi:10.1073/pnas.0405077101. PMID 15310849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.