Melatonin receptor 1A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Melatonin receptor type 1A''' is a [[protein]] that in humans is encoded by the ''MTNR1A'' [[gene]].<ref name="pmid7558006">{{cite journal | vauthors = Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM | title = Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a) | journal = Genomics | volume = 27 | issue = 2 | pages = 355–7 | date = May 1995 | pmid = 7558006 | pmc =  | doi = 10.1006/geno.1995.1056 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTNR1A melatonin receptor 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4543| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melatonin receptor 1A
| HGNCid = 7463
| Symbol = MTNR1A
| AltSymbols =; MT1; MEL-1A-R
| OMIM = 600665
| ECnumber = 
| Homologene = 21207
| MGIid = 102967
| GeneAtlas_image1 = PBB_GE_MTNR1A_221369_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008502 |text = melatonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007617 |text = mating behavior}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4543
    | Hs_Ensembl = ENSG00000168412
    | Hs_RefseqProtein = NP_005949
    | Hs_RefseqmRNA = NM_005958
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 187691803
    | Hs_GenLoc_end = 187713531
    | Hs_Uniprot = P48039
    | Mm_EntrezGene = 17773
    | Mm_Ensembl = ENSMUSG00000054764
    | Mm_RefseqmRNA = XM_991330
    | Mm_RefseqProtein = XP_996424
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 46568027
    | Mm_GenLoc_end = 46587323
    | Mm_Uniprot = Q14AC3
  }}
}}
'''Melatonin receptor 1A''', also known as '''MTNR1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTNR1A melatonin receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4543| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes the MT<sub>1</sub> [[protein]], one of two high-affinity forms of a receptor for [[melatonin]], the primary hormone secreted by the [[pineal gland]]. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian [[circadian rhythm]] and reproductive alterations affected by day length. The receptor is an [[integral membrane protein]] that is readily detectable and localized to two specific regions of the brain. The [[hypothalamic]] [[suprachiasmatic nucleus]] appears to be involved in circadian rhythm while the [[pituitary gland|hypophysial]] [[pars tuberalis]] may be responsible for the [[reproductive]] effects of melatonin.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.<ref name="entrez">{{cite web | title = Entrez Gene: MTNR1A melatonin receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4543| accessdate = }}</ref>
}}


==See also==
== Ligands ==
 
# [[Melatonin]] – full agonist
# [[Afobazole]] – agonist
# [[Agomelatine]] – agonist
 
== See also ==
* [[Melatonin receptor]]
* [[Melatonin receptor]]
* [[Discovery and development of melatonin receptor agonists]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Brzezinski A | title = Melatonin in humans | journal = The New England Journal of Medicine | volume = 336 | issue = 3 | pages = 186–95 | date = Jan 1997 | pmid = 8988899 | doi = 10.1056/NEJM199701163360306 }}
| citations =
* {{cite journal | vauthors = Khan AU, Olson DL | title = Physical therapy and exercise-induced bronchospasm | journal = Physical Therapy | volume = 55 | issue = 8 | pages = 878–81 | date = Aug 1975 | pmid = 1144527 | doi =  }}
*{{cite journal | author=Brzezinski A |title=Melatonin in humans. |journal=N. Engl. J. Med. |volume=336 |issue= 3 |pages= 186-95 |year= 1997 |pmid= 8988899 |doi= }}
* {{cite journal | vauthors = Reppert SM, Weaver DR, Ebisawa T | title = Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses | journal = Neuron | volume = 13 | issue = 5 | pages = 1177–85 | date = Nov 1994 | pmid = 7946354 | doi = 10.1016/0896-6273(94)90055-8 }}
*{{cite journal | author=Khan AU, Olson DL |title=Physical therapy and exercise-induced bronchospasm. |journal=Physical therapy |volume=55 |issue= 8 |pages= 878-81 |year= 1975 |pmid= 1144527 |doi=  }}
* {{cite journal | vauthors = Witt-Enderby PA, Dubocovich ML | title = Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells | journal = Molecular Pharmacology | volume = 50 | issue = 1 | pages = 166–74 | date = Jul 1996 | pmid = 8700109 | doi =  }}
*{{cite journal | author=Slaugenhaupt SA, Roca AL, Liebert CB, ''et al.'' |title=Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). |journal=Genomics |volume=27 |issue= 2 |pages= 355-7 |year= 1995 |pmid= 7558006 |doi= 10.1006/geno.1995.1056 }}
* {{cite journal | vauthors = Witt-Enderby PA, Masana MI, Dubocovich ML | title = Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor | journal = Endocrinology | volume = 139 | issue = 7 | pages = 3064–71 | date = Jul 1998 | pmid = 9645677 | doi = 10.1210/en.139.7.3064 }}
*{{cite journal  | author=Reppert SM, Weaver DR, Ebisawa T |title=Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. |journal=Neuron |volume=13 |issue= 5 |pages= 1177-85 |year= 1994 |pmid= 7946354 |doi= }}
* {{cite journal | vauthors = Ebisawa T, Kajimura N, Uchiyama M, Katoh M, Sekimoto M, Watanabe T, Ozeki Y, Ikeda M, Jodoi T, Sugishita M, Iwase T, Kamei Y, Kim K, Shibui K, Kudo Y, Yamada N, Toyoshima R, Okawa M, Takahashi K, Yamauchi T | title = Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders | journal = Biochemical and Biophysical Research Communications | volume = 262 | issue = 3 | pages = 832–7 | date = Sep 1999 | pmid = 10471411 | doi = 10.1006/bbrc.1999.1308 }}
*{{cite journal | author=Witt-Enderby PA, Dubocovich ML |title=Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells. |journal=Mol. Pharmacol. |volume=50 |issue= 1 |pages= 166-74 |year= 1996 |pmid= 8700109 |doi=  }}
* {{cite journal | vauthors = Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan PJ, Nanoff C, Strosberg AD, Jockers R | title = Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins | journal = Molecular Endocrinology | volume = 13 | issue = 12 | pages = 2025–38 | date = Dec 1999 | pmid = 10598579 | doi = 10.1210/me.13.12.2025 }}
*{{cite journal | author=Witt-Enderby PA, Masana MI, Dubocovich ML |title=Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor. |journal=Endocrinology |volume=139 |issue= 7 |pages= 3064-71 |year= 1998 |pmid= 9645677 |doi= }}
* {{cite journal | vauthors = Niles LP, Wang J, Shen L, Lobb DK, Younglai EV | title = Melatonin receptor mRNA expression in human granulosa cells | journal = Molecular and Cellular Endocrinology | volume = 156 | issue = 1-2 | pages = 107–10 | date = Oct 1999 | pmid = 10612428 | doi = 10.1016/S0303-7207(99)00135-5 }}
*{{cite journal | author=Ebisawa T, Kajimura N, Uchiyama M, ''et al.'' |title=Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 3 |pages= 832-7 |year= 1999 |pmid= 10471411 |doi= 10.1006/bbrc.1999.1308 }}
* {{cite journal | vauthors = Song CK, Bartness TJ | title = CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 281 | issue = 2 | pages = R666–72 | date = Aug 2001 | pmid = 11448873 | doi =  }}
*{{cite journal | author=Brydon L, Roka F, Petit L, ''et al.'' |title=Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2025-38 |year= 2000 |pmid= 10598579 |doi= }}
* {{cite journal | vauthors = Roy D, Angelini NL, Fujieda H, Brown GM, Belsham DD | title = Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin | journal = Endocrinology | volume = 142 | issue = 11 | pages = 4711–20 | date = Nov 2001 | pmid = 11606436 | doi = 10.1210/en.142.11.4711 }}
*{{cite journal | author=Niles LP, Wang J, Shen L, ''et al.'' |title=Melatonin receptor mRNA expression in human granulosa cells. |journal=Mol. Cell. Endocrinol. |volume=156 |issue= 1-2 |pages= 107-10 |year= 2000 |pmid= 10612428 |doi= }}
* {{cite journal | vauthors = Savaskan E, Olivieri G, Meier F, Brydon L, Jockers R, Ravid R, Wirz-Justice A, Müller-Spahn F | title = Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients | journal = Journal of Pineal Research | volume = 32 | issue = 1 | pages = 59–62 | date = Jan 2002 | pmid = 11841602 | doi = 10.1034/j.1600-079x.2002.00841.x }}
*{{cite journal | author=Song CK, Bartness TJ |title=CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=281 |issue= 2 |pages= R666-72 |year= 2001 |pmid= 11448873 |doi=  }}
* {{cite journal | vauthors = Savaskan E, Wirz-Justice A, Olivieri G, Pache M, Kräuchi K, Brydon L, Jockers R, Müller-Spahn F, Meyer P | title = Distribution of melatonin MT1 receptor immunoreactivity in human retina | journal = The Journal of Histochemistry and Cytochemistry | volume = 50 | issue = 4 | pages = 519–26 | date = Apr 2002 | pmid = 11897804 | doi = 10.1177/002215540205000408 }}
*{{cite journal | author=Roy D, Angelini NL, Fujieda H, ''et al.'' |title=Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. |journal=Endocrinology |volume=142 |issue= 11 |pages= 4711-20 |year= 2001 |pmid= 11606436 |doi= }}
* {{cite journal | vauthors = Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, Jockers R | title = Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21522–8 | date = Jun 2002 | pmid = 11940583 | doi = 10.1074/jbc.M200729200 }}
*{{cite journal | author=Savaskan E, Olivieri G, Meier F, ''et al.'' |title=Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. |journal=J. Pineal Res. |volume=32 |issue= 1 |pages= 59-62 |year= 2002 |pmid= 11841602 |doi= }}
* {{cite journal | vauthors = Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM | title = MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells | journal = Molecular and Cellular Endocrinology | volume = 192 | issue = 1-2 | pages = 147–56 | date = Jun 2002 | pmid = 12088876 | doi = 10.1016/S0303-7207(02)00029-1 }}
*{{cite journal | author=Savaskan E, Wirz-Justice A, Olivieri G, ''et al.'' |title=Distribution of melatonin MT1 receptor immunoreactivity in human retina. |journal=J. Histochem. Cytochem. |volume=50 |issue= 4 |pages= 519-26 |year= 2002 |pmid= 11897804 |doi= }}
* {{cite journal | vauthors = Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J | title = Functional activity of serotoninergic and melatoninergic systems expressed in the skin | journal = Journal of Cellular Physiology | volume = 196 | issue = 1 | pages = 144–53 | date = Jul 2003 | pmid = 12767050 | doi = 10.1002/jcp.10287 }}
*{{cite journal | author=Ayoub MA, Couturier C, Lucas-Meunier E, ''et al.'' |title=Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21522-8 |year= 2002 |pmid= 11940583 |doi= 10.1074/jbc.M200729200 }}
* {{cite journal | vauthors = Morcuende JA, Minhas R, Dolan L, Stevens J, Beck J, Wang K, Weinstein SL, Sheffield V | title = Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis | journal = Spine | volume = 28 | issue = 17 | pages = 2025–8; discussion 2029 | date = Sep 2003 | pmid = 12973153 | doi = 10.1097/01.BRS.0000083235.74593.49 }}
*{{cite journal | author=Yuan L, Collins AR, Dai J, ''et al.'' |title=MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells. |journal=Mol. Cell. Endocrinol. |volume=192 |issue= 1-2 |pages= 147-56 |year= 2003 |pmid= 12088876 |doi= }}
* {{cite journal | vauthors = Aust S, Thalhammer T, Humpeler S, Jäger W, Klimpfinger M, Tucek G, Obrist P, Marktl W, Penner E, Ekmekcioglu C | title = The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia | journal = Journal of Pineal Research | volume = 36 | issue = 1 | pages = 43–8 | date = Jan 2004 | pmid = 14675129 | doi = 10.1046/j.1600-079X.2003.00095.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144-53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
*{{cite journal | author=Morcuende JA, Minhas R, Dolan L, ''et al.'' |title=Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis. |journal=Spine |volume=28 |issue= 17 |pages= 2025-8; discussion 2029 |year= 2004 |pmid= 12973153 |doi= 10.1097/01.BRS.0000083235.74593.49 }}
*{{cite journal | author=Aust S, Thalhammer T, Humpeler S, ''et al.'' |title=The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia. |journal=J. Pineal Res. |volume=36 |issue= 1 |pages= 43-8 |year= 2004 |pmid= 14675129 |doi= }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Melatonergics}}
{{WikiDoc Sources}}
 
[[Category:G protein-coupled receptors]]
[[Category:Human proteins]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 12:02, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.[1][2]

Function

This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.[2]

Ligands

  1. Melatonin – full agonist
  2. Afobazole – agonist
  3. Agomelatine – agonist

See also

References

  1. ↑ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (May 1995). "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)". Genomics. 27 (2): 355–7. doi:10.1006/geno.1995.1056. PMID 7558006.
  2. ↑ 2.0 2.1 "Entrez Gene: MTNR1A melatonin receptor 1A".

Further reading

  • Brzezinski A (Jan 1997). "Melatonin in humans". The New England Journal of Medicine. 336 (3): 186–95. doi:10.1056/NEJM199701163360306. PMID 8988899.
  • Khan AU, Olson DL (Aug 1975). "Physical therapy and exercise-induced bronchospasm". Physical Therapy. 55 (8): 878–81. PMID 1144527.
  • Reppert SM, Weaver DR, Ebisawa T (Nov 1994). "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses". Neuron. 13 (5): 1177–85. doi:10.1016/0896-6273(94)90055-8. PMID 7946354.
  • Witt-Enderby PA, Dubocovich ML (Jul 1996). "Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells". Molecular Pharmacology. 50 (1): 166–74. PMID 8700109.
  • Witt-Enderby PA, Masana MI, Dubocovich ML (Jul 1998). "Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor". Endocrinology. 139 (7): 3064–71. doi:10.1210/en.139.7.3064. PMID 9645677.
  • Ebisawa T, Kajimura N, Uchiyama M, Katoh M, Sekimoto M, Watanabe T, Ozeki Y, Ikeda M, Jodoi T, Sugishita M, Iwase T, Kamei Y, Kim K, Shibui K, Kudo Y, Yamada N, Toyoshima R, Okawa M, Takahashi K, Yamauchi T (Sep 1999). "Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders". Biochemical and Biophysical Research Communications. 262 (3): 832–7. doi:10.1006/bbrc.1999.1308. PMID 10471411.
  • Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan PJ, Nanoff C, Strosberg AD, Jockers R (Dec 1999). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Molecular Endocrinology. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579.
  • Niles LP, Wang J, Shen L, Lobb DK, Younglai EV (Oct 1999). "Melatonin receptor mRNA expression in human granulosa cells". Molecular and Cellular Endocrinology. 156 (1–2): 107–10. doi:10.1016/S0303-7207(99)00135-5. PMID 10612428.
  • Song CK, Bartness TJ (Aug 2001). "CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281 (2): R666–72. PMID 11448873.
  • Roy D, Angelini NL, Fujieda H, Brown GM, Belsham DD (Nov 2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology. 142 (11): 4711–20. doi:10.1210/en.142.11.4711. PMID 11606436.
  • Savaskan E, Olivieri G, Meier F, Brydon L, Jockers R, Ravid R, Wirz-Justice A, Müller-Spahn F (Jan 2002). "Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients". Journal of Pineal Research. 32 (1): 59–62. doi:10.1034/j.1600-079x.2002.00841.x. PMID 11841602.
  • Savaskan E, Wirz-Justice A, Olivieri G, Pache M, Kräuchi K, Brydon L, Jockers R, Müller-Spahn F, Meyer P (Apr 2002). "Distribution of melatonin MT1 receptor immunoreactivity in human retina". The Journal of Histochemistry and Cytochemistry. 50 (4): 519–26. doi:10.1177/002215540205000408. PMID 11897804.
  • Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, Jockers R (Jun 2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". The Journal of Biological Chemistry. 277 (24): 21522–8. doi:10.1074/jbc.M200729200. PMID 11940583.
  • Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM (Jun 2002). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Molecular and Cellular Endocrinology. 192 (1–2): 147–56. doi:10.1016/S0303-7207(02)00029-1. PMID 12088876.
  • Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J (Jul 2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". Journal of Cellular Physiology. 196 (1): 144–53. doi:10.1002/jcp.10287. PMID 12767050.
  • Morcuende JA, Minhas R, Dolan L, Stevens J, Beck J, Wang K, Weinstein SL, Sheffield V (Sep 2003). "Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis". Spine. 28 (17): 2025–8, discussion 2029. doi:10.1097/01.BRS.0000083235.74593.49. PMID 12973153.
  • Aust S, Thalhammer T, Humpeler S, Jäger W, Klimpfinger M, Tucek G, Obrist P, Marktl W, Penner E, Ekmekcioglu C (Jan 2004). "The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia". Journal of Pineal Research. 36 (1): 43–8. doi:10.1046/j.1600-079X.2003.00095.x. PMID 14675129.


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