MAS1 oncogene
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| MAS1 oncogene | |
|---|---|
| Identifiers | |
| Symbol | MAS1 |
| Entrez | 4142 |
| HUGO | 6899 |
| OMIM | 165180 |
| RefSeq | NM_002377 |
| UniProt | P04201 |
| Other data | |
| Locus | Chr. 6 q24-q27 |
| MAS1 oncogene-like | |
|---|---|
| Identifiers | |
| Symbol | MAS1L |
| Entrez | 116511 |
| HUGO | 13961 |
| OMIM | 607235 |
| RefSeq | NM_052967 |
| UniProt | P35410 |
| Other data | |
| Locus | Chr. 6 p21 |
The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite Angiotensin (1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4]
References
- ↑ Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691.
- ↑ Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
- ↑ Santos RA, Ferreira AJ (2007). "Angiotensin-(1-7) and the renin-angiotensin system". Curr. Opin. Nephrol. Hypertens. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID 17293687.
- ↑ Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular drug reviews. 24 (3–4): 239–46. doi:10.1111/j.1527-3466.2006.00239.x. PMID 17214600.
External links
- IUPHAR GPCR Database - MAS1
- IUPHAR GPCR Database - MAS1L
- proto-oncogene+proteins+c-mas-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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