LGR4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Leucine-rich repeat-containing G-protein coupled receptor 4''' is a [[protein]] that in humans is encoded by the ''LGR4'' [[gene]].<ref name="pmid10894923">{{cite journal |vauthors=Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, ((Kolakowski LF Jr)) | title = Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping | journal = Cytogenet Cell Genet | volume = 89 | issue = 1–2 | pages = 2–5 |date=Aug 2000 | pmid = 10894923 | pmc = | doi =10.1159/000015576  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55366| accessdate = }}</ref> LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.
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Mutations in this gene have been associated to [[osteoporosis]] (doi:10.1038/nature12124).
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Leucine-rich repeat-containing G protein-coupled receptor 4
| HGNCid = 13299
| Symbol = LGR4
| AltSymbols =; GPR48
| OMIM = 606666
| ECnumber = 
| Homologene = 10226
| MGIid = 1891468
| GeneAtlas_image1 = PBB_GE_LGR4_218326_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016500 |text = protein-hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55366
    | Hs_Ensembl = ENSG00000205213
    | Hs_RefseqProtein = NP_060960
    | Hs_RefseqmRNA = NM_018490
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 27344086
    | Hs_GenLoc_end = 27450869
    | Hs_Uniprot = Q9BXB1
    | Mm_EntrezGene = 107515
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_355385
    | Mm_RefseqProtein = XP_355385
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Leucine-rich repeat-containing G protein-coupled receptor 4''', also known as '''LGR4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55366| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hsu SY, Liang SG, Hsueh AJ |title=Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1830-45 |year= 1999 |pmid= 9849958 |doi= }}
*{{cite journal  |vauthors=Hsu SY, Liang SG, Hsueh AJ |title=Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1830–45 |year= 1999 |pmid= 9849958 |doi=10.1210/me.12.12.1830 }}
*{{cite journal  | author=Loh ED, Broussard SR, Liu Q, ''et al.'' |title=Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 2-5 |year= 2000 |pmid= 10894923 |doi= }}
*{{cite journal  |vauthors=Loh ED, Broussard SR, Kolakowski LF |title=Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 757–64 |year= 2001 |pmid= 11401528 |doi= 10.1006/bbrc.2001.4625 }}
*{{cite journal  | author=Loh ED, Broussard SR, Kolakowski LF |title=Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 757-64 |year= 2001 |pmid= 11401528 |doi= 10.1006/bbrc.2001.4625 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[1][2] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).


References

  1. ↑ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923.
  2. ↑ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Further reading

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