Immunoglobulin domain cl11960

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Associate Editor(s)-in-Chief: Henry A. Hoff

The United States National Library of Medicine (NLM) is a biomedical library in the United States as part of the National Institutes of Health that contains "hierarchical classifications of widely distributed protein domain families [and records] conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research."[1]

"At the time of writing, the CDD version v3.17 is the live production version with 52,910 protein- and protein domain-models obtained from Pfam (1), SMART (2), the COGs collection (3), TIGRFAMS (4), the NCBI Protein Clusters collection (5), NCBIfam (6) and CDD’s in-house data curation effort (7)."[1]

Immunoglobulin supergene family

Main article: Immunoglobulin supergene family

The immunoglobulin supergene family is "the group of proteins that have immunoglobulin-like domains, including histocompatibility antigens, the T-cell antigen receptor, poly-IgR, and other proteins involved in the vertebrate immune response (17)."[2]

Alpha-1-B glycoprotein variants

Gene ID: 1 A1BG alpha-1-B glycoprotein on 19q13.43: "The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins."[3]

"𝛂1B-glycoprotein(𝛂1B) [...] consists of a single polypeptide chain N-linked to four glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues. [...] 𝛂1B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond. [...] several domains of 𝛂1B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 𝛂1B [...] exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."[2]

"Some of the domains of 𝛂1B show significant homology to variable (V) and constant (C) regions of certain immunoglobulins. Likewise, there is statistically significant homology between 𝛂1B and the secretory component (SC) of human IgA (15) and also with the extracellular portion of the rabbit receptor for transepithelial transport of polymeric immunoglobulins (IgA and IgM). Mostov et al. (16) have called the later protein the poly-Ig receptor or poly-IgR and have shown that it is the precursor of SC."[2]

"𝛂1B-glycoprotein(𝛂1B) [...] consists of a single polypeptide chain N-linked to four glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues. [...] 𝛂1B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond. [...] several domains of 𝛂1B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 𝛂1B [...] exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."[2]

A1BG contains the immunoglobulin domain: cl11960 and three immunoglobulin-like domains: pfam13895, cd05751 and smart00410.

"Immunoglobulin (Ig) domain [cl11960] found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond."[4]

Carcinoembryonic antigen gene family

Main article: Carcinoembryonic antigen gene family

Immunoglobulin superfamily genes

Main article: Immunoglobulin superfamily

Major histocompatibility complex genes

Main article: Major histocompatibility complex

Class I

Main article: MHC class I
Main article: Major histocompatibility complex class I gene family

Class II

Main article: MHC class II
Main article: Major histocompatibility complex class II gene family

Class III

Main article: MHC class III
Main article: Major histocompatibility complex class III gene family

Immunoglobulin domain genes

Main article: Immunoglobulin domain genes

Immunoglobulin receptor superfamily

Main article: Immunoglobulin receptor superfamily genes

Genes having immunoglobulin domain cl11960

Gene ID: 1 see Immunoglobulin domain genes.

Gene ID: 177 see Major histocompatibility complex class III gene family.

Gene ID: 214 see Carcinoembryonic antigen gene family.

Gene ID: 634 see Carcinoembryonic antigen gene family.

Gene ID: 682 see Immunoglobulin supergene family.

Gene ID: 915 see Immunoglobulin domain genes.

Gene ID: 924 see Immunoglobulin supergene family.

Gene ID: 942 see Immunoglobulin like domain pfam13895.

Gene ID: 1048 see Carcinoembryonic antigen gene family.

Gene ID: 1630 see Immunoglobulin receptor superfamily genes.

Gene ID: 1826 see Carcinoembryonic antigen gene family.

Gene ID: 2204 see Immunoglobulin like domain cd05751.

Gene ID: 2263 is FGFR2 fibroblast growth factor receptor 2 on 10q26.13: "The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene."[5]

  1. NP_000132.3 fibroblast growth factor receptor 2 isoform 1 precursor: "Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform BEK and K-sam."[5] Conserved Domains (7) summary: cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 271 → 360 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 174 → 248 IG; Immunoglobulin, and smart00410 Location: 263 → 359 IG_like; Immunoglobulin like.[5]
  2. NP_001138385.1 fibroblast growth factor receptor 2 isoform 3 precursor: "Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1."[5] Conserved Domains (6) summary cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 271 → 358 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and smart00410 Location: 263 → 357 IG_like; Immunoglobulin like.[5]
  3. NP_001138386.1 fibroblast growth factor receptor 2 isoform 4 precursor: "Transcript Variant: This variant (4) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (4) lacking an internal protein segment compared to isoform 1."[5] Conserved Domains (5) summary: cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and smart00410 Location: 47 → 124 IG_like; Immunoglobulin like.[5]
  4. NP_001138387.1 fibroblast growth factor receptor 2 isoform 5 precursor: "Transcript Variant: This variant (5) uses an alternate 5' terminal non-coding exon, and is missing an internal in-frame coding exon, compared to transcript variant 1. This results in a shorter isoform (5) lacking an internal protein segment compared to isoform 1."[5] Conserved Domains (6) summary: cd05857 Location: 75 → 159 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 182 → 271 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 85 → 159 IG; Immunoglobulin, and smart00410 Location: 174 → 270 IG_like; Immunoglobulin like.[5]
  5. NP_001138388.1 fibroblast growth factor receptor 2 isoform 6 precursor: "Transcript Variant: This variant (6) uses an alternate 5' terminal exon, and is missing two consecutive in-frame coding exons, compared to transcript variant 1. This results in a shorter isoform (6) lacking an internal protein segment compared to isoform 1."[5] Conserved Domains (6) summary: cd05857 Location: 49 → 133 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 156 → 245 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 59 → 133 IG; Immunoglobulin, and smart00410 Location: 148 → 244 IG_like; Immunoglobulin like.[5]
  6. NP_001138389.1 fibroblast growth factor receptor 2 isoform 7 precursor: "Transcript Variant: This variant (7) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (7) lacking an internal protein segment compared to isoform 1."[5] Conserved Domains (6) summary: cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 47 → 124 IG_like; Immunoglobulin like, and cl11960 Location: 271 → 363 Ig; Immunoglobulin domain.[5]
  7. NP_001138390.1 fibroblast growth factor receptor 2 isoform 8 precursor: "Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1."[5] Conserved Domains (3) summary: cd05857 Location: 49 → 133 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 156 → 245 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).[5]
  8. NP_001138391.1 fibroblast growth factor receptor 2 isoform 9 precursor: "Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1."[5] Conserved Domains (6) summary: cd04974 Location: 182 → 269 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 75 → 159 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00409 Location: 85 → 159 IG; Immunoglobulin, and smart00410 Location: 174 → 268 IG_like; Immunoglobulin like.[5]
  9. NP_001307583.1 fibroblast growth factor receptor 2 isoform 15: "Transcript Variant: This variant (15) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (15) with a shorter N-terminus compared to isoform 1."[5] Conserved Domains (2) summary: cd05858 Location: 43 → 132 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).[5]
  10. NP_001307587.1 fibroblast growth factor receptor 2 isoform 16 precursor: "Transcript Variant: This variant (16) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (16) is shorter than isoform 1."[5] Conserved Domains (7) summary: cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 271 → 360 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 174 → 248 IG; Immunoglobulin, and smart00410 Location: 263 → 359 IG_like; Immunoglobulin like.[5]
  11. NP_075259.4 fibroblast growth factor receptor 2 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1."[5] Conserved Domains (6) summary: cd04973 Location: 47 → 124 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 271 → 358 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR) cd05857 Location: 164 → 248 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and smart00410 Location: 263 → 357IG_like; Immunoglobulin like.[5]
  12. NP_075418.1 fibroblast growth factor receptor 2 isoform 11 precursor: "Transcript Variant: This variant (11) lacks an in-frame coding exon in the 5' region, compared to variant 1. This results in a shorter isoform (11) lacking an internal protein segment compared to isoform 1."[5] Conserved Domains (6) summary: cd05857 Location: 75 → 159 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 182 → 271 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 85 → 159 IG; Immunoglobulin, and smart00410 Location: 174 → 270 IG_like; Immunoglobulin like.[5]
  13. XP_016871410.1 fibroblast growth factor receptor 2 isoform X4, Conserved Domains (7) summary: cd04973 Location: 66 → 143 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 183 → 267 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 290 → 379 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00409 Location: 193 → 267 IG; Immunoglobulin, and smart00410 Location: 282 → 378 IG_like; Immunoglobulin like.[5]
  14. XP_006717773.1 fibroblast growth factor receptor 2 isoform X2, Conserved Domains (6) summary: cd04973 Location: 66 → 143 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 290 → 377 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 183 → 267 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 282 → 376 IG_like; Immunoglobulin like.[5]
  15. XP_006717771.1 fibroblast growth factor receptor 2 isoform X1, Conserved Domains (6) summary: cd04973 Location: 66 → 143 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 290 → 377 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 183 → 267 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 282 → 376 IG_like; Immunoglobulin like.[5]
  16. XP_024303657.1 fibroblast growth factor receptor 2 isoform X7, Conserved Domains (3) summary: cd05857 Location: 94 → 178 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 201 → 290 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).[5]
  17. XP_024303656.1 fibroblast growth factor receptor 2 isoform X6, Conserved Domains (3) summary: cd05857 Location: 94 → 178 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cl11960 Location: 201 → 288 Ig; Immunoglobulin domain.[5]
  18. XP_024303658.1 fibroblast growth factor receptor 2 isoform X8, Conserved Domains (3) summary: cd05857 Location: 94 → 178 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cl11960 Location: 201 → 288 Ig; Immunoglobulin domain.[5]
  19. XP_024303659.1 fibroblast growth factor receptor 2 isoform X9, Conserved Domains (3) summary: cd05857 Location: 68 → 152 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor and cl11960 Location: 175 → 262 Ig; Immunoglobulin domain.[5]
  20. XP_024303655.1 fibroblast growth factor receptor 2 isoform X5, Conserved Domains (3) summary: cd05857 Location: 94 → 178 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 201 → 290 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).[5]

Gene ID: 2321 is FLT1 fms related receptor tyrosine kinase 1: "This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia."[6]

  1. NP_001153392.1 vascular endothelial growth factor receptor 1 isoform 2 precursor: "Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1."[6] Conserved Domains (5) summary: cd07702 Location: 353 → 424 Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1), smart00409 Location: 143 → 219 IG; Immunoglobulin, smart00410 Location: 568 → 640 IG_like; Immunoglobulin like, pfam13927 Location: 427 → 539 Ig_3; Immunoglobulin domain, and cl11960 Location: 245 → 327 Ig; Immunoglobulin domain.[6]
  2. NP_001153502.1 vascular endothelial growth factor receptor 1 isoform 3 precursor: "Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 3) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1."[6] Conserved Domains (5) summary: cd05742 Location: 245 → 327 Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins, cd07702 Location: 353 → 424 Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1), smart00408 Location: 569 → 640 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 237 → 328 IG_like; Immunoglobulin like, and cl11960 Location: 671 → 708 Ig; Immunoglobulin domain.[6]
  3. NP_001153503.1 vascular endothelial growth factor receptor 1 isoform 4 precursor: "Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 4) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1."[6] Conserved Domains (4) summary: cd05742 Location: 245 → 327 Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins, cd07702 Location: 353 → 424 Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1), smart00410 Location: 237 → 328 IG_like; Immunoglobulin like, and cl11960 Location: 439 → 466 Ig; Immunoglobulin domain.[6]
  4. NP_002010.2 vascular endothelial growth factor receptor 1 isoform 1 precursor: "Transcript Variant: This variant (1) the longest isoform (1). Isoform 1 is a transmembrane protein."[6] Conserved Domains (8) summary: cd05742 Location: 245 → 327 Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins, cd07702 Location: 353 → 424 Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1), smart00408 Location: 676 → 738 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 568 → 640 IG; Immunoglobulin, smart00410 Location: 237 → 328 IG_like; Immunoglobulin like, and pfam07679 Location: 661 → 748 I-set; Immunoglobulin I-set domain.[6]
  5. XP_011533316.1 vascular endothelial growth factor receptor 1 isoform X2, Conserved Domains (5) summary: cd05742 Location: 245 → 327 Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins, cd07702 Location: 353 → 424 Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1), smart00408 Location: 569 → 640 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 237 → 328 IG_like; Immunoglobulin like, and cl11960 Location: 660 → 720 Ig; Immunoglobulin domain.[6]

Gene ID: 2324 see Immunoglobulin like domain pfam13895.

Gene ID: 3084 see Immunoglobulin like domain smart00410.

Gene ID: 3321 see Immunoglobulin supergene family.

Gene ID: 3339 see Immunoglobulin like domain pfam13895.

Gene ID: 3383 see Carcinoembryonic antigen gene family.

Gene ID: 3385 see Carcinoembryonic antigen gene family.

Gene ID: 3791 see Immunoglobulin like domain smart00410.

Gene ID: 3805 see Immunoglobulin receptor superfamily genes.

Gene ID: 3811 see Immunoglobulin receptor superfamily genes.

Gene ID: 3812 see Immunoglobulin receptor superfamily genes.

Gene ID: 3897 see Carcinoembryonic antigen gene family.

Gene ID: 3904 see Immunoglobulin receptor superfamily genes.

Gene ID: 4059 see Carcinoembryonic antigen gene family.

Gene ID: 4680 see Carcinoembryonic antigen gene family.

Gene ID: 4684 see Carcinoembryonic antigen gene family.

Gene ID: 4685 see Carcinoembryonic antigen gene family.

Gene ID: 4897 see Carcinoembryonic antigen gene family.

Gene ID: 4978 see Carcinoembryonic antigen gene family.

Gene ID: 5156 see Immunoglobulin like domain smart00410.

Gene ID: 5175 see Carcinoembryonic antigen gene family.

Gene ID: 5159 see Immunoglobulin like domain smart00410.

Gene ID: 7087 see Carcinoembryonic antigen gene family.

Gene ID: 7273 see Immunoglobulin like domain smart00410.

Gene ID: 7441 see Immunoglobulin supergene family.

Gene ID: 8174 see Carcinoembryonic antigen gene family.

Gene ID: 8482 see Immunoglobulin domain genes.

Gene ID: 10288 see Immunoglobulin receptor superfamily genes.

Gene ID: 10507 see Immunoglobulin domain genes.

Gene ID: 10752 see Carcinoembryonic antigen gene family.

Gene ID: 10859 see Immunoglobulin receptor superfamily genes.

Gene ID: 11006 see Immunoglobulin receptor superfamily genes.

Gene ID: 11024 see Immunoglobulin receptor superfamily genes.

Gene ID: 11025 see Immunoglobulin like domain cd05751.

Gene ID: 11026 see Immunoglobulin receptor superfamily genes.

Gene ID: 11027 see Immunoglobulin receptor superfamily genes.

Gene ID: 11326 see Immunoglobulin domain genes.

Gene ID: 23547 see Immunoglobulin receptor superfamily genes.

Gene ID: 26103 see Immunoglobulin domain genes.

Gene ID: 29126 see Immunoglobulin like domain smart00410.

Gene ID: 50937 see Carcinoembryonic antigen gene family.

Gene ID: 51206 see Immunoglobulin like domain cd05751.

Gene ID: 57453 see Carcinoembryonic antigen gene family.

Gene ID: 59307 see Immunoglobulin domain genes.

Gene ID: 79037 see Immunoglobulin domain genes.

Gene ID: 79168 see Immunoglobulin domain genes.

Gene ID: 83417 see Immunoglobulin receptor superfamily genes.

Gene ID: 90273 see Carcinoembryonic antigen gene family.

Gene ID: 115352 see Immunoglobulin receptor superfamily genes.

Gene ID: 115653 see Immunoglobulin receptor superfamily genes.

Gene ID: 120425 see Carcinoembryonic antigen gene family.

Gene ID: 125931 see Carcinoembryonic antigen gene family.

Gene ID: 126014 see Immunoglobulin receptor superfamily genes.

Gene ID: 126259 see Immunoglobulin domain genes.

Gene ID: 150084 see Immunoglobulin supergene family.

Gene ID: 199731 see Carcinoembryonic antigen gene family.

Gene ID: 285313 see Immunoglobulin supergene family.

Gene ID: 339398 see Immunoglobulin domain genes.

Gene ID: 102725035 see Immunoglobulin like domain cd05751.

Gene ID: 107987425 see Immunoglobulin like domain cd05751.

Gene ID: 107987462 see Immunoglobulin like domain cd05751.

Hypotheses

  1. Downstream core promoters may work as transcription factors even as their complements or inverses.
  2. In addition to the DNA binding sequences listed above, the transcription factors that can open up and attach through the local epigenome need to be known and specified.
  3. The function of A1BG is the same as other immunoglobulin genes possessing the immunoglobulin domain cl11960 and/or any of three immunoglobulin-like domains: pfam13895, cd05751 and smart00410 in the order and nucleotide sequence: cd05751 Location: 401 → 493, smart00410 Location: 218 → 280, pfam13895 Location: 210 → 301 and cl11960 Location: 28 → 110.

See also

References

  1. ↑ 1.0 1.1 Shennan Lu, Jiyao Wang, Farideh Chitsaz, Myra K Derbyshire, Renata C Geer, Noreen R Gonzales, Marc Gwadz, David I Hurwitz, Gabriele H Marchler, James S Song, Narmada Thanki, Roxanne A Yamashita, Mingzhang Yang, Dachuan Zhang, Chanjuan Zheng, Christopher J Lanczycki, and Aron Marchler-Bauer (8 January 2020). "CDD/SPARCLE: The Conserved Domain Database in 2020". Nucleic Acids Research. 48 (D1): D265–D268. doi:10.1093/nar/gkz991. PMID 31777944. Retrieved 24 June 2020.
  2. ↑ 2.0 2.1 2.2 2.3 Noriaki Ishioka, Nobuhiro Takahashi, and Frank W. Putnam (April 1986). "Amino acid sequence of human plasma 𝛂1B-glycoprotein: Homology to the immunoglobulin supergene family" (PDF). Proceedings of the National Academy of Sciences USA. 83 (8): 2363–7. doi:10.1073/pnas.83.8.2363. PMID 3458201. Retrieved 9 March 2020.
  3. ↑ RefSeq (July 2008). "A1BG alpha-1-B glycoprotein [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 17 April 2020.
  4. ↑ NCBI (2 February 2016). "Conserved Protein Domain Family cl11960: Ig Superfamily". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 22 May 2020.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 RefSeq (January 2009). "FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 15 June 2020.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 RefSeq (May 2009). "FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 19 June 2020.

External links

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