GPR132

G protein-coupled receptor 132
Identifiers
Symbols	GPR132 ; G2A; MGC99642
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8350
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

G protein-coupled receptor 132, also known as GPR132, is a human gene.

This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.

Further reading

• Weng Z, Fluckiger AC, Nisitani S; et al. (1998). "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334–9. PMID 9770487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kabarowski JH, Zhu K, Le LQ; et al. (2001). "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A". Science. 293 (5530): 702–5. doi:10.1126/science.1061781. PMID 11474113.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le LQ, Kabarowski JH, Wong S; et al. (2002). "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene". Cancer Cell. 1 (4): 381–91. PMID 12086852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rikitake Y, Hirata K, Yamashita T; et al. (2002). "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049–53. PMID 12482833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin P, Ye RD (2003). "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis". J. Biol. Chem. 278 (16): 14379–86. doi:10.1074/jbc.M209101200. PMID 12586833.
• Lum H, Qiao J, Walter RJ; et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). "G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine". J. Biol. Chem. 279 (41): 42484–91. doi:10.1074/jbc.M406561200. PMID 15280385.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Witte ON, Kabarowski JH, Xu Y; et al. (2005). "Retraction". Science. 307 (5707): 206. doi:10.1126/science.307.5707.206b. PMID 15653487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radu CG, Nijagal A, McLaughlin J; et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMID 15665078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Obinata H, Hattori T, Nakane S; et al. (2006). "Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A". J. Biol. Chem. 280 (49): 40676–83. doi:10.1074/jbc.M507787200. PMID 16236715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frasch SC, Zemski-Berry K, Murphy RC; et al. (2007). "Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A". J. Immunol. 178 (10): 6540–8. PMID 17475884.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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