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{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 124''' is a [[protein]] that in humans is encoded by the ''GPR124'' [[gene]].<ref name="pmid11559528">{{cite journal |vauthors=Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St  Croix B | title = Cell surface tumor endothelial markers are conserved in mice and humans | journal = Cancer Res | volume = 61 | issue = 18 | pages = 6649–55 | date=September 2001| pmid = 11559528 | pmc =  | doi =  }}</ref><ref name="pmid12565841">{{cite journal |vauthors=Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB | title = There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini | journal = Biochem Biophys Res Commun | volume = 301 | issue = 3 | pages = 725–34 | date=February 2003| pmid = 12565841 | pmc =  | doi =10.1016/S0006-291X(03)00026-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR124 G protein-coupled receptor 124| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25960| accessdate = }}</ref>  It is a member of the [[adhesion-GPCRs|adhesion-GPCR]] family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing ([[GAIN domain|GAIN]]) domain.<ref name="isbn1-4419-7912-3">{{cite book |vauthors=Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref><ref name="pmid12435584">{{cite journal |vauthors=Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Lett | volume = 531 | issue = 3 | pages = 407–14 |date=Nov 2002 | pmid = 12435584 | pmc =  | doi =10.1016/S0014-5793(02)03574-3  }}</ref><ref name="pmid22333914">{{cite journal |vauthors=Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = EMBO J. | volume = 31 | issue = 6 | pages = 1364–78 |date=March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 | url = }}</ref>
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| update_protein_box = yes
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==Interactions==
{{GNF_Protein_box
GPR124 has been shown to [[Protein-protein interaction|interact]] with [[DLG1]].<ref name="pmid15021905">{{cite journal |vauthors=Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y | title = Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein | journal = Oncogene | volume = 23 | issue = 22 | pages = 3889–97 |date=May 2004 | pmid = 15021905 | doi = 10.1038/sj.onc.1207495 }}</ref>
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 124
| HGNCid = 17849
| Symbol = GPR124
| AltSymbols =; DKFZp434C211; DKFZp434J0911; FLJ14390; KIAA1531; TEM5
| OMIM = 606823
| ECnumber = 
| Homologene = 13112
| MGIid = 1925810
| GeneAtlas_image1 = PBB_GE_GPR124_221814_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR124_65718_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25960
    | Hs_Ensembl = ENSG00000020181
    | Hs_RefseqProtein = NP_116166
    | Hs_RefseqmRNA = NM_032777
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 37773582
    | Hs_GenLoc_end = 37820652
    | Hs_Uniprot = Q96PE1
    | Mm_EntrezGene = 78560
    | Mm_Ensembl = ENSMUSG00000031486
    | Mm_RefseqmRNA = NM_054044
    | Mm_RefseqProtein = NP_473385
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 28551777
    | Mm_GenLoc_end = 28589358
    | Mm_Uniprot = Q91ZV8
  }}
}}
'''G protein-coupled receptor 124''', also known as '''GPR124''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR124 G protein-coupled receptor 124| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25960| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
| citations =
*{{cite journal  |vauthors=Nagase T, Kikuno R, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143  |display-authors=etal}}
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi= }}
*{{cite journal  |vauthors=Yamamoto Y, Irie K, Asada M |title=Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. |journal=Oncogene |volume=23 |issue= 22 |pages= 3889–97 |year= 2004 |pmid= 15021905 |doi= 10.1038/sj.onc.1207495 |display-authors=etal}}
*{{cite journal  | author=Carson-Walter EB, Watkins DN, Nanda A, ''et al.'' |title=Cell surface tumor endothelial markers are conserved in mice and humans. |journal=Cancer Res. |volume=61 |issue= 18 |pages= 6649-55 |year= 2001 |pmid= 11559528 |doi=  }}
*{{cite journal  |vauthors=Bjarnadóttir TK, Fredriksson R, Höglund PJ |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Vallon M, Essler M |title=Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34179–88 |year= 2006 |pmid= 16982628 |doi= 10.1074/jbc.M605291200 }}
*{{cite journal  | author=Fredriksson R, Gloriam DE, Höglund PJ, ''et al.'' |title=There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 725-34 |year= 2003 |pmid= 12565841 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Yamamoto Y, Irie K, Asada M, ''et al.'' |title=Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. |journal=Oncogene |volume=23 |issue= 22 |pages= 3889-97 |year= 2004 |pmid= 15021905 |doi= 10.1038/sj.onc.1207495 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal  | author=Vallon M, Essler M |title=Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34179-88 |year= 2006 |pmid= 16982628 |doi= 10.1074/jbc.M605291200 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{DEFAULTSORT:Gpr124}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Revision as of 08:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4][5][6]

Interactions

GPR124 has been shown to interact with DLG1.[7]

References

  1. ↑ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID 11559528.
  2. ↑ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
  3. ↑ "Entrez Gene: GPR124 G protein-coupled receptor 124".
  4. ↑ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  5. ↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
  6. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  7. ↑ Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905.

Further reading


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