FZD3: Difference between revisions

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{{Infobox_gene}}
'''Frizzled-3''' is a [[protein]] that in humans is encoded by the ''FZD3'' [[gene]].<ref name="pmid10777673">{{cite journal |vauthors=Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M | title = Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21 | journal = Biochem Biophys Res Commun | volume = 271 | issue = 1 | pages = 8–14 | date = Jun 2000 | pmid = 10777673 | pmc =  | doi = 10.1006/bbrc.2000.2578 }}</ref><ref name="pmid10873558">{{cite journal |vauthors=Sala CF, Formenti E, Terstappen GC, Caricasole A | title = Identification, gene structure, and expression of human frizzled-3 (FZD3) | journal = Biochem Biophys Res Commun | volume = 273 | issue = 1 | pages = 27–34 | date = Jul 2000 | pmid = 10873558 | pmc =  | doi = 10.1006/bbrc.2000.2882 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976| accessdate = }}</ref>


== Function ==


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This gene is a member of the [[frizzled]] gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the [[beta-catenin]] canonical signaling pathway.  It may play a role in mammalian hair follicle development.<ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.<ref name=" pmid24347548">{{cite journal |vauthors=Hua ZL, Smallwood PM, Nathans J | title = Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons | journal = eLife | volume = 2 | issue =  | pages = e01482 | date = Dec 2013 | pmid = 24347548 | pmc = 3865743 | doi = 10.7554/eLife.01482 }}</ref><ref name=" pmid24799694">{{cite journal |vauthors=Hua ZL, Jeon S, Caterina MJ, Nathans J | title = Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system | journal = Proc Natl Acad Sci U S A | volume = 111 | issue = 29 | pages = E3005-14 | date = Jul 2014 | pmid = 24799694 | pmc = 4115534 | doi = 10.1073/pnas.1406399111 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Frizzled homolog 3 (Drosophila)
| HGNCid = 4041
| Symbol = FZD3
| AltSymbols =; Fz-3; hFz3
| OMIM = 606143
| ECnumber = 
| Homologene = 23004
| MGIid = 108476
| GeneAtlas_image1 = PBB_GE_FZD3_219683_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0001736 |text = establishment of planar polarity}} {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7976
    | Hs_Ensembl = ENSG00000104290
    | Hs_RefseqProtein = NP_059108
    | Hs_RefseqmRNA = NM_017412
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 28407692
    | Hs_GenLoc_end = 28487707
    | Hs_Uniprot = Q9NPG1
    | Mm_EntrezGene = 14365
    | Mm_Ensembl = ENSMUSG00000007989
    | Mm_RefseqmRNA = NM_021458
    | Mm_RefseqProtein = NP_067433
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 64156448
    | Mm_GenLoc_end = 64216534
    | Mm_Uniprot = Q3TUV1
  }}
}}
'''Frizzled homolog 3 (Drosophila)''', also known as '''FZD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =  
| summary_text = This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.<ref name="entrez">{{cite web | title = Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976| accessdate = }}</ref>
}}


==See also==
==See also==
Line 64: Line 16:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | author = Katoh M | title = GIPC gene family (Review). | journal = Int. J. Mol. Med. | volume = 9 | issue = 6 | pages = 585–9 | year = 2002 | pmid = 12011974 | doi = 10.3892/ijmm.9.6.585 }}
| citations =
*{{cite journal |vauthors=Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 13 | pages = 6770–5 | year = 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 }}
*{{cite journal | author=Katoh M |title=GIPC gene family (Review). |journal=Int. J. Mol. Med. |volume=9 |issue= 6 |pages= 585-9 |year= 2002 |pmid= 12011974 |doi= }}
*{{cite journal |vauthors=Wright M, Aikawa M, Szeto W, Papkoff J | title = Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. | journal = Biochem. Biophys. Res. Commun. | volume = 263 | issue = 2 | pages = 384–8 | year = 1999 | pmid = 10491302 | doi = 10.1006/bbrc.1999.1344 }}
*{{cite journal | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi= }}
*{{cite journal |vauthors=Hung BS, Wang XQ, Cam GR, Rothnagel JA | title = Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. | journal = J. Invest. Dermatol. | volume = 116 | issue = 6 | pages = 940–6 | year = 2001 | pmid = 11407985 | doi = 10.1046/j.1523-1747.2001.01336.x }}
*{{cite journal | author=Wright M, Aikawa M, Szeto W, Papkoff J |title=Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 384-8 |year= 1999 |pmid= 10491302 |doi= 10.1006/bbrc.1999.1344 }}
*{{cite journal |vauthors=Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S | title = The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. | journal = Neurosci. Lett. | volume = 353 | issue = 1 | pages = 53–6 | year = 2004 | pmid = 14642436 | doi = 10.1016/j.neulet.2003.09.017 }}
*{{cite journal | author=Kirikoshi H, Koike J, Sagara N, ''et al.'' |title=Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 1 |pages= 8-14 |year= 2000 |pmid= 10777673 |doi= 10.1006/bbrc.2000.2578 }}
*{{cite journal |vauthors=Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D | title = Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. | journal = Am. J. Med. Genet. B Neuropsychiatr. Genet. | volume = 129 | issue = 1 | pages = 16–9 | year = 2005 | pmid = 15274031 | doi = 10.1002/ajmg.b.30076 }}
*{{cite journal  | author=Sala CF, Formenti E, Terstappen GC, Caricasole A |title=Identification, gene structure, and expression of human frizzled-3 (FZD3). |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 27-34 |year= 2000 |pmid= 10873558 |doi= 10.1006/bbrc.2000.2882 }}
*{{cite journal |vauthors=Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites. | journal = Protein Sci. | volume = 13 | issue = 10 | pages = 2819–24 | year = 2005 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
*{{cite journal  | author=Hung BS, Wang XQ, Cam GR, Rothnagel JA |title=Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. |journal=J. Invest. Dermatol. |volume=116 |issue= 6 |pages= 940-6 |year= 2001 |pmid= 11407985 |doi= 10.1046/j.1523-1747.2001.01336.x }}
*{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). | journal = Ophthalmic Genet. | volume = 25 | issue = 2 | pages = 81–90 | year = 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H | title = Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. | journal = Journal of Neural Transmission | volume = 112 | issue = 2 | pages = 303–7 | year = 2005 | pmid = 15657645 | doi = 10.1007/s00702-004-0264-2 }}
*{{cite journal  | author=Katsu T, Ujike H, Nakano T, ''et al.'' |title=The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. |journal=Neurosci. Lett. |volume=353 |issue= 1 |pages= 53-6 |year= 2004 |pmid= 14642436 |doi= }}
*{{cite journal | author=Zhang Y, Yu X, Yuan Y, ''et al.'' |title=Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=129 |issue= 1 |pages= 16-9 |year= 2005 |pmid= 15274031 |doi= 10.1002/ajmg.b.30076 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal | author=Hashimoto R, Suzuki T, Iwata N, ''et al.'' |title=Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=112 |issue= 2 |pages= 303-7 |year= 2005 |pmid= 15657645 |doi= 10.1007/s00702-004-0264-2 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3061 | title = Frizzled Receptors: FZD<sub>3</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}
[[Category:G protein coupled receptors]]
 
[[Category:G protein-coupled receptors]]
 


{{WH}}
{{transmembranereceptor-stub}}
{{WS}}

Latest revision as of 08:50, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[3]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[4][5]

See also

References

  1. ↑ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
  2. ↑ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
  3. ↑ 3.0 3.1 "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
  4. ↑ Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife. 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
  5. ↑ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A. 111 (29): E3005–14. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.

Further reading

External links

  • "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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