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{{Infobox_gene}}
'''Frizzled-1''' is a [[protein]] that in humans is encoded by the ''FZD1'' [[gene]].<ref name="pmid9813155">{{cite journal | vauthors = Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 1 | pages = 117–22 | date = Nov 1998 | pmid = 9813155 | pmc =  | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8321| accessdate = }}</ref>


== Function ==


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Members of the '[[frizzled]]' gene family encode [[G protein–coupled receptor|7-transmembrane domain]] proteins that are receptors for [[Wnt signaling]] proteins.  The FZD1 protein contains a signal peptide, a cysteine-rich domain in the [[N-terminal]] extracellular region, 7 transmembrane domains, and a [[C-terminal]] [[PDZ domain]]-binding motif.  The FZD1 transcript is expressed in various tissues.<ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Frizzled homolog 1 (Drosophila)
| HGNCid = 4038
| Symbol = FZD1
| AltSymbols =; DKFZp564G072
| OMIM = 603408
| ECnumber = 
| Homologene = 20750
| MGIid = 1196625
| GeneAtlas_image1 = PBB_GE_FZD1_204451_at_tn.png
| GeneAtlas_image2 = PBB_GE_FZD1_204452_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8321
    | Hs_Ensembl = ENSG00000157240
    | Hs_RefseqProtein = NP_003496
    | Hs_RefseqmRNA = NM_003505
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 90731719
    | Hs_GenLoc_end = 90736059
    | Hs_Uniprot = Q9UP38
    | Mm_EntrezGene = 14362
    | Mm_Ensembl = ENSMUSG00000044674
    | Mm_RefseqmRNA = NM_021457
    | Mm_RefseqProtein = NP_067432
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 4761658
    | Mm_GenLoc_end = 4763586
    | Mm_Uniprot = Q7TS82
  }}
}}
'''Frizzled homolog 1 (Drosophila)''', also known as '''FZD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8321| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.  The FZD1 transcript is expressed in various tissues.<ref name="entrez">{{cite web | title = Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8321| accessdate = }}</ref>
}}
 
==See also==
* [[Frizzled]]
* [[Frizzled]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 17 | pages = 10164–9 | date = Aug 1998 | pmid = 9707618 | pmc = 21479 | doi = 10.1073/pnas.95.17.10164 }}
| citations =
* {{cite journal | vauthors = Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA | title = Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response | journal = Oncogene | volume = 18 | issue = 44 | pages = 5959–66 | date = Oct 1999 | pmid = 10557084 | doi = 10.1038/sj.onc.1202985 }}
*{{cite journal | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi=  }}
* {{cite journal | vauthors = DeCostanzo AJ, Huang XP, Wang HY, Malbon CC | title = The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 365 | issue = 5 | pages = 341–8 | date = May 2002 | pmid = 12012019 | doi = 10.1007/s00210-002-0540-3 }}
*{{cite journal  | author=Sagara N, Toda G, Hirai M, ''et al.'' |title=Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 117-22 |year= 1998 |pmid= 9813155 |doi= 10.1006/bbrc.1998.9607 }}
* {{cite journal | vauthors = Hering H, Sheng M | title = Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 | journal = FEBS Letters | volume = 521 | issue = 1-3 | pages = 185–9 | date = Jun 2002 | pmid = 12067714 | doi = 10.1016/S0014-5793(02)02831-4 }}
*{{cite journal | author=Gazit A, Yaniv A, Bafico A, ''et al.'' |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. |journal=Oncogene |volume=18 |issue= 44 |pages= 5959-66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985 }}
* {{cite journal | vauthors = Zilberberg A, Yaniv A, Gazit A | title = The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway | journal = The Journal of Biological Chemistry | volume = 279 | issue = 17 | pages = 17535–42 | date = Apr 2004 | pmid = 14739301 | doi = 10.1074/jbc.M311292200 }}
*{{cite journal | author=DeCostanzo AJ, Huang XP, Wang HY, Malbon CC |title=The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor. |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=365 |issue= 5 |pages= 341-8 |year= 2002 |pmid= 12012019 |doi= 10.1007/s00210-002-0540-3 }}
* {{cite journal | vauthors = Wu J, Klein TJ, Mlodzik M | title = Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity | journal = PLoS Biology | volume = 2 | issue = 7 | pages = E158 | date = Jul 2004 | pmid = 15252441 | pmc = 449784 | doi = 10.1371/journal.pbio.0020158 }} {{open access}}
*{{cite journal | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185-9 |year= 2002 |pmid= 12067714 |doi=  }}
* {{cite journal | vauthors = Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genetics | volume = 25 | issue = 2 | pages = 81–90 | date = Jun 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K | title = Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes | journal = Journal of Dermatological Science | volume = 42 | issue = 2 | pages = 111–9 | date = May 2006 | pmid = 16442268 | doi = 10.1016/j.jdermsci.2005.12.011 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Zilberberg A, Yaniv A, Gazit A |title=The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17535-42 |year= 2004 |pmid= 14739301 |doi= 10.1074/jbc.M311292200 }}
*{{cite journal | author=Wu J, Klein TJ, Mlodzik M |title=Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E158 |year= 2006 |pmid= 15252441 |doi= 10.1371/journal.pbio.0020158 }}
*{{cite journal | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Yang L, Yamasaki K, Shirakata Y, ''et al.'' |title=Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. |journal=J. Dermatol. Sci. |volume=42 |issue= 2 |pages= 111-9 |year= 2006 |pmid= 16442268 |doi= 10.1016/j.jdermsci.2005.12.011 }}
}}
{{refend}}
{{refend}}
== External links ==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3059 | title = Frizzled Receptors: FZD<sub>1</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 00:57, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.[1][2]

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]

See also

References

  1. ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  2. ↑ 2.0 2.1 "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

Further reading

External links

  • "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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