F2RL3
| Coagulation factor II (thrombin) receptor-like 3 | |||||||||||
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| Symbols | F2RL3 ; PAR4 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 36148 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Coagulation factor II (thrombin) receptor-like 3, also known as F2RL3 or protease activated receptor 4 (PAR4), is a human gene.[1]
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]
See also
References
Further reading
- Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases". Circulation. 114 (10): 1070–7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.
- Xu WF, Andersen H, Whitmore TE; et al. (1998). "Cloning and characterization of human protease-activated receptor 4". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. PMID 9618465.
- Kahn ML, Zheng YW, Huang W; et al. (1998). "A dual thrombin receptor system for platelet activation". Nature. 394 (6694): 690–4. doi:10.1038/29325. PMID 9716134.
- Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family". J. Biol. Chem. 273 (36): 23290–6. PMID 9722561.
- Kahn ML, Nakanishi-Matsui M, Shapiro MJ; et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879–87. PMID 10079109.
- Andersen H, Greenberg DL, Fujikawa K; et al. (1999). "Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. PMID 10500152.
- Page G, Kögel D, Rangnekar V, Scheidtmann KH (2000). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene. 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
- Sambrano GR, Huang W, Faruqi T; et al. (2000). "Cathepsin G activates protease-activated receptor-4 in human platelets". J. Biol. Chem. 275 (10): 6819–23. PMID 10702240.
- Nakanishi-Matsui M, Zheng YW, Sulciner DJ; et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin". Nature. 404 (6778): 609–13. doi:10.1038/35007085. PMID 10766244.
- Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. PMID 11714832.
- Asokananthan N, Graham PT, Fink J; et al. (2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells". J. Immunol. 168 (7): 3577–85. PMID 11907122.
- Henriksen RA, Hanks VK (2002). "PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets". Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. PMID 12006403.
- Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome". Thromb. Haemost. 87 (4): 722–7. PMID 12008957.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin". Biochem. Biophys. Res. Commun. 305 (1): 166–8. PMID 12732212.
- Adam F, Verbeuren TJ, Fauchère JL; et al. (2003). "Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP". J. Thromb. Haemost. 1 (4): 798–804. PMID 12871418.
- Wu CC, Hwang TL, Liao CH; et al. (2004). "The role of PAR4 in thrombin-induced thromboxane production in human platelets". Thromb. Haemost. 90 (2): 299–308. doi:10.1267/THRO03020299. PMID 12888878.
- Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. 23 (17): 6174–86. PMID 12917339.
- Jacques SL, Kuliopulos A (2004). "Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage". Biochem. J. 376 (Pt 3): 733–40. doi:10.1042/BJ20030954. PMID 13678420.
- Han Y, Nurden A, Combrié R, Pasquet JM (2004). "Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium". J. Thromb. Haemost. 1 (10): 2206–15. PMID 14521606.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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