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{{Infobox gene}}
'''EGF-like module-containing mucin-like hormone receptor-like 1''' also known as '''F4/80''' is a [[protein]] encoded by the ''ADGRE1'' [[gene]].<ref name="pmid7601460">{{cite journal | vauthors = Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M | title = EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments | journal = Genomics | volume = 26 | issue = 2 | pages = 334–44 | date = March 1995 | pmid = 7601460 | pmc =  | doi = 10.1016/0888-7543(95)80218-B }}</ref><ref name="pmid9500513">{{cite journal | vauthors = McKnight AJ, Gordon S | title = The EGF-TM7 family: unusual structures at the leukocyte surface | journal = Journal of Leukocyte Biology | volume = 63 | issue = 3 | pages = 271–80 | date = March 1998 | pmid = 9500513 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }}</ref><ref name="pmid8083537">{{cite journal | vauthors = Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W | title = Markers of mouse macrophage development detected by monoclonal antibodies | journal = Journal of Immunological Methods | volume = 174 | issue = 1–2 | pages = 5–19 | date = September 1994 | pmid = 8083537 | doi = 10.1016/0022-1759(94)90005-1 }}</ref><ref>{{cite journal|last1=Hamann|first1=J|last2=Aust|first2=G|last3=Araç|first3=D|last4=Engel|first4=FB|last5=Formstone|first5=C|last6=Fredriksson|first6=R|last7=Hall|first7=RA|last8=Harty|first8=BL|last9=Kirchhoff|first9=C|last10=Knapp|first10=B|last11=Krishnan|first11=A|last12=Liebscher|first12=I|last13=Lin|first13=HH|last14=Martinelli|first14=DC|last15=Monk|first15=KR|last16=Peeters|first16=MC|last17=Piao|first17=X|last18=Prömel|first18=S|last19=Schöneberg|first19=T|last20=Schwartz|first20=TW|last21=Singer|first21=K|last22=Stacey|first22=M|last23=Ushkaryov|first23=YA|last24=Vallon|first24=M|last25=Wolfrum|first25=U|last26=Wright|first26=MW|last27=Xu|first27=L|last28=Langenhan|first28=T|last29=Schiöth|first29=HB|title=International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.|journal=Pharmacological Reviews|date=April 2015|volume=67|issue=2|pages=338–67|pmid=25713288|doi=10.1124/pr.114.009647|pmc=4394687}}</ref> EMR1 is a member of the [[adhesion-GPCRs|adhesion GPCR]] family.<ref name="isbn1-4419-7912-3">{{cite book | author = Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref><ref>{{cite journal|last1=Langenhan|first1=T|last2=Aust|first2=G|last3=Hamann|first3=J|title=Sticky signaling--adhesion class G protein-coupled receptors take the stage.|journal=Science Signaling|date=21 May 2013|volume=6|issue=276|pages=re3|pmid=23695165|doi=10.1126/scisignal.2003825}}</ref>
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing [[GAIN domain|(GAIN)]] domain.<ref name="pmid22333914">{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–78 | date = March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}</ref>


EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.<ref>{{cite journal | vauthors = Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ | title = EMR1, the human homolog of F4/80, is an eosinophil-specific receptor | journal = European Journal of Immunology | volume = 37 | issue = 10 | pages = 2797–802 | date = October 2007 | pmid = 17823986 | doi = 10.1002/eji.200737553 }}</ref> The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.<ref>{{cite journal | vauthors = Austyn JM, Gordon S | title = F4/80, a monoclonal antibody directed specifically against the mouse macrophage | journal = European Journal of Immunology | volume = 11 | issue = 10 | pages = 805–15 | date = October 1981 | pmid = 7308288 | doi = 10.1002/eji.1830111013 }}</ref> The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like ([[EGF-like domain|EGF-like]]) domains in human and 4-7 EGF-like domains in the mouse.<ref>{{cite journal | vauthors = Gordon S, Hamann J, Lin HH, Stacey M | title = F4/80 and the related adhesion-GPCRs | journal = European Journal of Immunology | volume = 41 | issue = 9 | pages = 2472–6 | date = September 2011 | pmid = 21952799 | doi = 10.1002/eji.201141715 }}</ref>


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
== Function ==
{{PBB_Controls
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8<sup>+</sup> regulatory T cells needed for peripheral tolerance.<ref>{{cite journal | vauthors = Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J | title = The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance | journal = The Journal of Experimental Medicine | volume = 201 | issue = 10 | pages = 1615–25 | date = May 2005 | pmid = 15883173 | doi = 10.1084/jem.20042307 | pmc=2212925}}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Egf-like module containing, mucin-like, hormone receptor-like 1
| HGNCid = 3336
| Symbol = EMR1
| AltSymbols =; TM7LN3
| OMIM = 600493
| ECnumber = 
| Homologene = 1493
| MGIid = 106912
| GeneAtlas_image1 = PBB_GE_EMR1_207111_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2015
    | Hs_Ensembl = ENSG00000174837
    | Hs_RefseqProtein = NP_001965
    | Hs_RefseqmRNA = NM_001974
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 6838577
    | Hs_GenLoc_end = 6891463
    | Hs_Uniprot = Q14246
    | Mm_EntrezGene = 13733
    | Mm_Ensembl = ENSMUSG00000004730
    | Mm_RefseqmRNA = NM_010130
    | Mm_RefseqProtein = NP_034260
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 57044026
    | Mm_GenLoc_end = 57168862
    | Mm_Uniprot = Q3S4B0
  }}
}}
'''Egf-like module containing, mucin-like, hormone receptor-like 1''', also known as '''EMR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{PBB_Summary
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.<ref>{{cite journal | vauthors = Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD | title = The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders | journal = The Journal of Allergy and Clinical Immunology | volume = 133 | issue = 5 | pages = 1439–47, 1447.e1-8 | date = May 2014 | pmid = 24530099 | doi = 10.1016/j.jaci.2013.11.041 | pmc=4113341}}</ref>
| section_title =  
| summary_text = This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.<ref name="entrez">{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[EGF module-containing mucin-like hormone receptor]]
* [[EGF module-containing mucin-like hormone receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}


==Further reading==
== External links ==
{{refbegin | 2}}
* [http://www.adhesiongpcr.org/Adhesion GPCR consortium]
{{PBB_Further_reading
| citations =  
*{{cite journal  | author=McKnight AJ, Gordon S |title=The EGF-TM7 family: unusual structures at the leukocyte surface. |journal=J. Leukoc. Biol. |volume=63 |issue= 3 |pages= 271-80 |year= 1998 |pmid= 9500513 |doi=  }}
*{{cite journal  | author=Baud V, Chissoe SL, Viegas-Péquignot E, ''et al.'' |title=EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. |journal=Genomics |volume=26 |issue= 2 |pages= 334-44 |year= 1995 |pmid= 7601460 |doi=  }}
*{{cite journal  | author=McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S |title=Chromosome mapping of the Emr1 gene. |journal=Mamm. Genome |volume=8 |issue= 12 |pages= 946 |year= 1998 |pmid= 9383301 |doi=  }}
*{{cite journal  | author=Carver EA, Hamann J, Olsen AS, Stubbs L |title=Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication. |journal=Mamm. Genome |volume=10 |issue= 10 |pages= 1039-40 |year= 2000 |pmid= 10501980 |doi=  }}
*{{cite journal  | author=Lin HH, Stacey M, Hamann J, ''et al.'' |title=Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. |journal=Genomics |volume=67 |issue= 2 |pages= 188-200 |year= 2000 |pmid= 10903844 |doi= 10.1006/geno.2000.6238 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}


{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Use dmy dates|date=April 2017}}


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}

Latest revision as of 23:44, 15 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.[1][2][3][4][5] EMR1 is a member of the adhesion GPCR family.[6][7] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8]

EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.[9] The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.[10] The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.[11]

Function

Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.[12]

Clinical significance

Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.[13]

See also

References

  1. ↑ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
  2. ↑ McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. PMID 9500513.
  3. ↑ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
  4. ↑ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID 8083537.
  5. ↑ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  6. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  7. ↑ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.
  8. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  9. ↑ Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID 17823986.
  10. ↑ Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID 7308288.
  11. ↑ Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.
  12. ↑ Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine. 201 (10): 1615–25. doi:10.1084/jem.20042307. PMC 2212925. PMID 15883173.
  13. ↑ Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.

External links

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