Dexetimide: Difference between revisions

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{{drugbox |
{{Drugbox
| IUPAC_name = 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione
| Verifiedfields = changed
| verifiedrevid = 460779595
| IUPAC_name = 3-(1-benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione
| image = Dexetimide.svg
| image = Dexetimide.svg
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|dexetimide}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK = <!-- GSL        / P      / POM / CD -->
| legal_US = <!-- OTC                  / Rx-only  -->
| legal_status = 
| routes_of_administration = 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 21888-98-2
| CAS_number = 21888-98-2
| ATC_prefix = N04
| ATC_prefix = N04
| ATC_suffix = AA08  
| ATC_suffix = AA08
| PubChem = 21847
| PubChem = 30843
| DrugBank =  
| IUPHAR_ligand = 354
| C = 23 | H = 26 | N = 2 | O = 2  
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB08997
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 28615
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 43477QYX3D
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D03711
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1908364
 
<!--Chemical data-->
| C=23 | H=26 | N=2 | O=2  
| molecular_weight = 362.465 g/mol
| molecular_weight = 362.465 g/mol
| bioavailability =  
| smiles = O=C2NC(=O)CCC2(c1ccccc1)C4CCN(Cc3ccccc3)CC4
| protein_bound =  
| InChI = 1/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)
| metabolism =  
| InChIKey = LQQIVYSCPWCSSD-UHFFFAOYAB
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =
| StdInChI = 1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = LQQIVYSCPWCSSD-HSZRJFAPSA-N
| pregnancy_category = 
| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US =      <!-- OTC                  / Rx-only  -->
| legal_status =  
| routes_of_administration =  
}}
}}
'''Dexetimide''' is a [[piperidine]] [[anticholinergic]]. It is a [[muscarinic acetylcholine receptor|muscarinic]] [[receptor antagonist|antagonist]] that has been used to treat [[neuroleptic]]-induced [[parkinsonism]]. Dexetimide was discovered at [[Janssen Pharmaceutica]] in [[1968]].


==References==
'''Dexetimide''' is a [[piperidine]] [[anticholinergic]]. It is a [[muscarinic acetylcholine receptor|muscarinic]] [[receptor antagonist|antagonist]] that has been used to treat [[neuroleptic]]-induced [[Parkinsonism]]. Dexetimide was discovered at [[Janssen Pharmaceutica]] in 1968.<ref>{{cite pmid|4947805}}</ref><ref>{{cite pmid|4581374}}</ref>
* Dom R, Van Lommel R, Baro F., A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent, Acta Psychiatr Scand. 1971;47(4):399-410.
 
* Huygens H, Vereecken JL, Tanghe A., Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action, Psychiatr Neurol Neurochir. 1973 Jul-Aug;76(4):251-9.
== References ==
{{Reflist}}


{{Antiparkinson}}
{{Cholinergics}}


[[Category:Muscarinic antagonists]]
[[Category:Muscarinic antagonists]]
{{drug-stub}}
[[Category:Piperidines]]
{{Anti-parkinson anticholinergic agents}}
[[Category:Glutarimides]]
[[Category:Janssen Pharmaceutica]]
[[Category:Belgian inventions]]
 
 
{{nervous-system-drug-stub}}

Revision as of 12:44, 13 April 2015

Dexetimide
File:Dexetimide.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC23H26N2O2
Molar mass362.465 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Dexetimide is a piperidine anticholinergic. It is a muscarinic antagonist that has been used to treat neuroleptic-induced Parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.[1][2]

References

  1. ↑ PMID 4947805 (PMID 4947805)
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  2. ↑ PMID 4581374 (PMID 4581374)
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Template:Antiparkinson


Template:Nervous-system-drug-stub

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