Carcinoembryonic antigen gene family

Associate Editor(s)-in-Chief: Henry A. Hoff

The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin superfamily, or immunoglobulin supergene family.

Carcinoembryonic antigen genes

Gene ID: 634 is CEACAM1 CEA cell adhesion molecule 1 on 19q13.2: "This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined."

1. NP_001020083.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 157 → 233 IG_like; Immunoglobulin like, pfam07679 Location: 317 → 408 I-set; Immunoglobulin I-set domain, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 340 → 415 Ig; Immunoglobulin domain.
2. NP_001171742.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor: "Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 157 → 233 IG_like; Immunoglobulin like, and pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain.
3. NP_001171744.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor: "Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 157 → 233 IG_like; Immunoglobulin like, and pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain.
4. NP_001171745.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor: "Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 157 → 233 IG_like; Immunoglobulin like, and pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain.
5. NP_001192273.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor: "Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), and cl11960 Location: 340 → 415 Ig; Immunoglobulin domain.
6. NP_001703.2 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L." Conserved Domains summary: cd05740 Location: 146 → 233 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 157 → 233 IG_like; Immunoglobulin like, pfam07679 Location: 317 → 408 I-set; Immunoglobulin I-set domain, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 340 → 415 Ig; Immunoglobulin domain.

Gene ID: 1048 is CEACAM5 CEA cell adhesion molecule 5 on 19q13.2: "This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants."

1. NP_001278413.1 carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein: "Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode isoform 1." Conserved Domains summary: cd05740 Location: 324 → 412 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 244 → 318 IG_like; Immunoglobulin like, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 502 → 590 Ig; Immunoglobulin domain.
2. NP_001295327.1 carcinoembryonic antigen-related cell adhesion molecule 5 isoform 2 preproprotein: "Transcript Variant: This variant (3) uses an alternate in-frame splice site at an internal exon and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1." Conserved Domains summary: cd05740 Location: 323 → 411 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 244 → 318 IG_like; Immunoglobulin like, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 501 → 589 Ig; Immunoglobulin domain.
3. NP_004354.3 carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform." Conserved Domains summary: cd05740 Location: 324 → 412 Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 244 → 318 IG_like; Immunoglobulin like, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 502 → 590 Ig; Immunoglobulin domain.

Gene ID: 1084 is CEACAM3 CEA cell adhesion molecule 3 on 19q13.2: "This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described."

1. NP_001264092.1 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate coding exon and has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1." Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM).
2. NP_001806.2 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longer isoform (1)." Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM).

Gene ID: 1087 is CEACAM7 CEA cell adhesion molecule 7 on 19q13.2: "This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants."

1. NP_001278414.1 carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein: "Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein." Conserved Domains summary: cd05774 Location: 38 → 141 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and cl11960 Location: 147 → 234 Ig; Immunoglobulin domain.
2. NP_008821.2 carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein: "Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein." Conserved Domains summary: cd05774 Location: 38 → 141 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and cl11960 Location: 147 → 234 Ig; Immunoglobulin domain.

Gene ID: 1088 is CEACAM8 CEA cell adhesion molecule 8 on 19q13.2.

1. NP_001807.2 carcinoembryonic antigen-related cell adhesion molecule 8 precursor, Conserved Domains summary: pfam13895 Location: 239 → 307 Ig_2; Immunoglobulin domain, cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and cl11960 Location: 146 → 234 Ig; Immunoglobulin domain.

Gene ID: 1089 is CEACAM4 CEA cell adhesion molecule 4 on 19q13.2.

1. NP_001349421.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 2 precursor, Conserved Domains summary: cd05774 Location: 37 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM).
2. NP_001349422.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 3.
3. NP_001349424.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 4 precursor, Conserved Domains summary: cd05774 Location: 37 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM).
4. NP_001808.2 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 1 precursor, Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and smart00410 Location: 44 → 140 IG_like; Immunoglobulin like.

Gene ID: 4680 is CEACAM6 CEA cell adhesion molecule 6 on 19q13.2: "This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19."

1. NP_002474.4 carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein, Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 244 → 312 IG_like; Immunoglobulin like, pfam13895 Location: 240 → 318 Ig_2; Immunoglobulin domain, and cl11960 Location: 146 → 234 Ig; Immunoglobulin domain.

Gene ID: 56971 is CEACAM19 CEA cell adhesion molecule 19 on 19q13.31.

1. NP_001121365.1 carcinoembryonic antigen-related cell adhesion molecule 19 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the shorter protein (isoform 1)." Conserved Domains summary: cl11960 Location: 36 → 140 Ig; Immunoglobulin domain.
2. NP_064604.2 carcinoembryonic antigen-related cell adhesion molecule 19 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is longer and has the same N- and C-termini compared to isoform 1." Conserved Domains summary: cl11960 Location: 36 → 140 Ig; Immunoglobulin domain.

Gene ID: 90273 is CEACAM21 CEA cell adhesion molecule 21 on 19q13.2.

1. NP_001091976.3 carcinoembryonic antigen-related cell adhesion molecule 21 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longest isoform (1)." Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and cl11960 Location: 142 → 232 Ig; Immunoglobulin domain.
2. NP_001275702.2 carcinoembryonic antigen-related cell adhesion molecule 21 isoform 3: "Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, compared to variant 1, and initiates translation at an alternate start codon. The resulting isoform (3) is shorter and has a different N-terminus, compared to isoform 1." Conserved Domains summary: cl11960 Location: 142 → 232 Ig; Immunoglobulin domain.
3. NP_001277042.1 carcinoembryonic antigen-related cell adhesion molecule 21 isoform 4: "Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a different N-terminus, compared to isoform 1." Conserved Domains summary: smart00410 Location: 24 → 104 IG_like; Immunoglobulin like and cl11960 Location: 14 → 104 Ig; Immunoglobulin domain.
4. NP_291021.4 carcinoembryonic antigen-related cell adhesion molecule 21 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1." Conserved Domains summary: cd05774 Location: 36 → 140 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 152 → 232 IG_like; Immunoglobulin like, and cl11960 Location: 142 → 232 Ig; Immunoglobulin domain.

Gene ID: 125931 is CEACAM20 CEA cell adhesion molecule 20 on 19q13.31.

1. NP_001096067.2 carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5L precursor: "Transcript Variant: This variant (5L) represents the longest transcript and encodes the longest isoform (5L)." Conserved Domains summary: pfam13927 Location: 361 → 420 I-set; Immunoglobulin I-set domain and cl11960 Location: 266 → 343 Ig; Immunoglobulin domain.
2. NP_001096068.2 carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4S precursor: "Transcript Variant: This variant (4S) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 5L, resulting in an isoform (4S) that is shorter than isoform 5L." Conserved Domains summary: smart00410 Location: 175 → 247 IG_like; Immunoglobulin like, pfam13895 Location: 175 → 247 Ig_2; Immunoglobulin domain, and cl11960 Location: 266 → 343 Ig; Immunoglobulin domain.
3. NP_001096069.2 carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4L precursor: "Transcript Variant: This variant (4L) lacks an alternate in-frame exon in the central coding region, compared to variant 5L, resulting in an isoform (4L) that is shorter than isoform 5L." Conserved Domains summary: smart00410 Location: 175 → 247 IG_like; Immunoglobulin like, pfam13895 Location: 175 → 247 Ig_2; Immunoglobulin domain, and cl11960 Location: 266 → 343 Ig; Immunoglobulin domain.
4. NP_001096070.2 carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5S precursor: "Transcript Variant: This variant (5S) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5L, resulting in an isoform (5S) that is shorter than isoform 5L." Conserved Domains summary: smart00410 Location: 361 → 433 IG_like; Immunoglobulin like, pfam13895 Location: 369 → 435 Ig_2; Immunoglobulin domain, and cl11960 Location: 266 → 343 Ig; Immunoglobulin domain.

Gene ID: 388551 is CEACAM16 CEA cell adhesion molecule 16, tectorial membrane component on 19q13.31-q13.32: "The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss."

1. NP_001034302.2 carcinoembryonic antigen-related cell adhesion molecule 16 precursor. Conserved Domains summary: cd05774 Location: 22 → 126 Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM), smart00410 Location: 139 → 219 IG_like; Immunoglobulin like, pfam07679 Location: 223 → 312 I-set; Immunoglobulin I-set domain, pfam13895 Location: 247 → 310 Ig_2; Immunoglobulin domain, and cl11960 Location: 143 → 219 Ig; Immunoglobulin domain.

Gene ID: 729767 is CEACAM18 CEA cell adhesion molecule 18 on 19q13.41.

1. NP_001265321.1 carcinoembryonic antigen-related cell adhesion molecule 18 precursor. Conserved Domains summary: smart00408 Location: 247 → 302 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 243 → 313 IG_like; Immunoglobulin like, and cl11960 Location: 42 → 132 Ig; Immunoglobulin domain.

Cell adhesion molecule genes

Gene ID: 214 is ALCAM activated leukocyte cell adhesion molecule on 3q13.11: "This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found."

1. NP_001230209.1 CD166 antigen isoform 2 precursor: "Transcript Variant: This variant (2) lacks an in-frame exon in the 3' CDS, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1." Conserved Domains summary: smart00406 Location: 38 → 113 IGv; Immunoglobulin V-Type, smart00410 Location: 255 → 329 IG_like; Immunoglobulin like, pfam08205 Location: 137 → 231 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 256 → 313 Ig_3; Immunoglobulin domain, and cl11960 Location: 415 → 488 Ig; Immunoglobulin domain.
2. NP_001230210.1 CD166 antigen isoform 3 precursor: "Transcript Variant: This variant (3) has a shorter and different 3' sequence, compared to variant 1. The resulting isoform (3) is truncated at the C-terminus, compared to isoform 1." Conserved Domains summary: smart00406 Location: 38 → 113 IGv; Immunoglobulin V-Type, smart00410 Location: 255 → 329 IG_like; Immunoglobulin like, pfam08205 Location: 137 → 231 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 256 → 313 Ig_3; Immunoglobulin domain, and cl11960 Location: 415 → 488 Ig; Immunoglobulin domain.
3. NP_001230212.1 CD166 antigen isoform 4 precursor: "Transcript Variant: This variant (4) lacks multiple 3' exons, and has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is the shortest; it is truncated at the C-terminus, compared to isoform 1." Conserved Domains summary: smart00406 Location: 38 → 113 IGv; Immunoglobulin V-Type and smart00410 Location: 36 → 130 IG_like; Immunoglobulin like.
4. NP_001618.2 CD166 antigen isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longest isoform (1)." Conserved Domains summary: smart00406 Location: 38 → 113 IGv; Immunoglobulin V-Type, smart00409 Location: 339 → 393 IG; Immunoglobulin, pfam08205 Location: 137 → 231 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 250 → 313 Ig_3; Immunoglobulin domain, and cl11960 Location: 415 → 488 Ig; Immunoglobulin domain.

Gene ID: 914 is CD2 CD2 molecule on 1p13.1: "The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene."

1. NP_001315538.1 T-cell surface antigen CD2 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)."
2. NP_001758.2 T-cell surface antigen CD2 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1." Conserved Domains summary: cd05741 Location: 38 → 122 Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins and pfam05790 Location: 135 → 205 C2-set; Immunoglobulin C2-set domain.

Gene ID: 933 is CD22 CD22 molecule on 19q13.12.

1. NP_001172028.1 B-cell receptor CD22 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1." Conserved Domains (5) summary: smart00408 Location: 257 → 316 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 518 → 589 IG_like; Immunoglobulin like, pfam07679 Location: 242 → 327 I-set; Immunoglobulin I-set domain, pfam08205 Location: 143 → 228 C2-set_2; CD80-like C2-set immunoglobulin domain and cl11960 Location: 24 → 122 Ig; Immunoglobulin domain.
2. NP_001172029.1 B-cell receptor CD22 isoform 3 precursor: "Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1." Conserved Domains (6) summary: smart00408 Location: 257 → 316 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 606 → 677 IG_like; Immunoglobulin like, pfam07679 Location: 242 → 327 I-set; Immunoglobulin I-set domain, pfam08205 Location: 143 → 228 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 335 → 400 Ig_3; Immunoglobulin domain and cl11960 Location: 24 → 122 Ig; Immunoglobulin domain.
3. NP_001172030.1 B-cell receptor CD22 isoform 4 precursor: "Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1." Conserved Domains (5) summary: smart00408 Location: 431 → 489 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 429 → 500 IG_like; Immunoglobulin like, pfam07679 Location: 333 → 412 I-set; Immunoglobulin I-set domain, pfam08205 Location: 143 → 228 C2-set_2; CD80-like C2-set immunoglobulin domain and cl11960 Location: 24 → 122 Ig; Immunoglobulin domain.
4. NP_001265346.1 B-cell receptor CD22 isoform 5: "Transcript Variant: This variant (5) lacks the exon containing the translation initiation site and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1." Conserved Domains (4) summary: smart00410 Location: 434 → 505 IG_like; Immunoglobulin like, pfam13927 Location: 163 → 228 Ig_3; Immunoglobulin domain, cl11960 Location: 4 → 56 Ig; Immunoglobulin domain and cl28434 Location: 70 → 155 I-set; Immunoglobulin I-set domain.
5. NP_001762.2 B-cell receptor CD22 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)." Conserved Domains (6) summary: smart00408 Location: 257 → 316 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 606 → 677 IG_like; Immunoglobulin like, pfam07679 Location: 242 → 327 I-set; Immunoglobulin I-set domain, pfam08205 Location: 143 → 228 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 335 → 400 Ig_3; Immunoglobulin domain and cl11960 Location: 24 → 122 Ig; Immunoglobulin domain.

Gene ID: 1826 is DSCAM DS cell adhesion molecule on 21q22.2: "This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene."

1. NP_001258463.1 Down syndrome cell adhesion molecule isoform 2: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform CHD2-42." Conserved Domains summary: cd00096 Location: 424 → 493 Ig; Immunoglobulin domain, cd05734 Location: 707 → 784 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 239 → 300 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 44 → 113 IG; Immunoglobulin, smart00410 Location: 236 → 310 IG_like; Immunoglobulin like, pfam07679 Location: 690 → 784 I-set; Immunoglobulin I-set domain, and cl11960 Location: 802 → 889 Ig; Immunoglobulin domain.
2. NP_001380.2 Down syndrome cell adhesion molecule isoform CHD2-42 precursor: "Transcript Variant: This variant (1) encodes the longer isoform (CHD2-42)." Conserved Domains summary: cd05734 Location: 707 → 784 Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 518 → 575 IGc2; Immunoglobulin C-2 Type, pfam07679, Location: 235 → 310 I-set; Immunoglobulin I-set domain, pfam13927 Location: 407 → 488 Ig_3; Immunoglobulin domain, cd00096 Location: 1303 → 1369 Ig; Immunoglobulin domain, cl11960 Location: 802 → 889 Ig; Immunoglobulin domain, and cl28434 Location: 596 → 686 I-set; Immunoglobulin I-set domain.
3. XP_016883770.1 Down syndrome cell adhesion molecule isoform X1 Conserved Domains (7) summary: cd00096 Location: 188 → 257 Ig; Immunoglobulin domain, cd05734 Location: 471 → 548 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 3 → 64 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 1 → 74 IG_like; Immunoglobulin like, pfam07679 Location: 454 → 548 I-set; Immunoglobulin I-set domain, and cl11960 Location: 566 → 653 Ig; Immunoglobulin domain.

Gene ID: 3897 is L1CAM L1 cell adhesion molecule on Xq28: "The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons."

1. NP_000416.1 neural cell adhesion molecule L1 isoform 1 precursor: "Transcript Variant: This variant (1, also known as FL-L1CAM) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 4. Variants 1 and 4 encode the same isoform (1)." Conserved Domains summary: cd05731 Location:260 → 330 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05733 Location: 53 → 130 Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, cd05867 Location:347 → 422 Ig4_L1-CAM_like; Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), smart00408 Location: 532 → 594 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 249 → 329 IG_like; Immunoglobulin like, pfam07679 Location: 519 → 608 I-set; Immunoglobulin I-set domain, cl11960 Location:134 → 228 Ig; Immunoglobulin domain.
2. NP_001137435.1 neural cell adhesion molecule L1 isoform 3 precursor: "Transcript Variant: This variant (3, also known as SV-L1CAM) lacks two alternate in-frame exons, one in the 5' coding region and the other (neuron-specific exon) in the 3' coding region, compared to variant 4. The resulting isoform (3) is shorter, and lacks an internal segment in the N-terminus and is missing a tyrosine-based sorting motif in the C-terminus, compared to isoform 1." Conserved Domains summary: cd05731 Location: 255 → 325 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05733 Location: 48 → 125 Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins cd05867 Location: 342 → 417 Ig4_L1-CAM_like; Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), smart00408 Location: 527 → 589 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 244 → 324 IG_like; Immunoglobulin like, pfam13882 Location: 1139 → 1224 Bravo_FIGEY; Bravo-like intracellular region, and cl11960 Location: 129 → 223 Ig; Immunoglobulin domain.
3. NP_001265045.1 neural cell adhesion molecule L1 isoform 1 precursor: "Transcript Variant: This variant (4) represents the longest transcript and its 5' UTR structure is inferred based on experimental data in PMID 20799950. Variants 1 and 4 encode the same isoform (1)." Conserved Domains summary: cd05731 Location: 260 → 330 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05733 Location: 53 → 130 Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, cd05867 Location: 347 → 422 Ig4_L1-CAM_like; Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), smart00408 Location: 532 → 594 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 249 → 329 IG_like; Immunoglobulin like, pfam07679 Location: 519 → 608 I-set; Immunoglobulin I-set domain, cl11960 Location: 134 → 228 Ig; Immunoglobulin domain.
4. NP_076493.1 neural cell adhesion molecule L1 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame neuron-specific exon in the 3' coding region, compared to variant 4. The resulting isoform (2) is shorter and lacks an internal segment containing a tyrosine-based sorting motif, compared to isoform 1." Conserved Domains summary: cd05731 Location: 260 → 330 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05733 Location: 53 → 130 Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, cd05867 Location: 347 → 422 Ig4_L1-CAM_like; Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), smart00408 Location: 532 → 594 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 249 → 329 IG_like; Immunoglobulin like, pfam07679 Location: 519 → 608 I-set; Immunoglobulin I-set domain, and cl11960 Location: 134 → 228 Ig; Immunoglobulin domain.

Gene ID: 4059 is BCAM basal cell adhesion molecule (Lutheran blood group) on 19q13.32: "This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene."

1. NP_001013275.1 basal cell adhesion molecule isoform 2 precursor: "Transcript Variant: This variant (2) includes an additional segment in its 3' coding region, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter at the C-terminus, compared to isoform 1. The full-length nature of this variant is supported by data in PMIDs 8781446 and 9192786." Conserved Domains summary: smart00408 Location: 283 → 341 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 280 → 358 IG_like; Immunoglobulin like, pfam08205 Location: 151 → 248 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13895 Location: 373 → 444 Ig_2; Immunoglobulin domain, and cl11960 Location4: 66 → 530 Ig; Immunoglobulin domain.
2. NP_005572.2 basal cell adhesion molecule isoform 1 precursor: "Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1)." Conserved Domains summary: smart00408 Location: 377 → 427 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 280 → 358 IG_like; Immunoglobulin like, pfam08205 Location: 151 → 248 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 464 → 526 Ig_3; Immunoglobulin domain, and cl11960 Location: 37 → 143 Ig; Immunoglobulin domain.

Gene ID: 4162 is MCAM melanoma cell adhesion molecule on 11q23.3.

1. NP_006491.2 cell surface glycoprotein MUC18 precursor, pfam08205 Location: 139 → 234 C2-set_2; CD80-like C2-set immunoglobulin domain, pfam13927 Location: 261 → 321 Ig_3; Immunoglobulin domain, and cl11960 Location: 450 → 510 Ig; Immunoglobulin domain.

Gene ID: 4684 is NCAM1 neural cell adhesion molecule 1 on 11q23.2: "This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants."

1. NP_000606.3 neural cell adhesion molecule 1 isoform 1 precursor: "Transcript Variant: This variant (1) lacks two alternate in-frame exons in the 3' coding region compared to variant 5. The resulting protein (isoform 1) is shorter compared to isoform 5." Conserved Domains summary: cd05865 Location: 20 → 115 Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, cd05869 Location:306 → 402 Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM), smart00409 Location: 124 → 190 IG; Immunoglobulin, pfam13927 Location: 411 → 483 Ig_3; Immunoglobulin domain, and cl11960 Location: 211 → 307 Ig; Immunoglobulin domain.
2. NP_001070150.1 neural cell adhesion molecule 1 isoform 3 precursor: "Transcript Variant: This variant (3) has multiple differences in the coding region and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 5." Conserved Domains summary: cd05865 Location: 20 → 115 Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, cd05869 Location: 306 → 402 Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM), smart00410 Location: 124 → 190 IG_like; Immunoglobulin like, pfam13927 Location: 411 → 483 Ig_3; Immunoglobulin domain, and cl11960 Location: 211 → 307 Ig; Immunoglobulin domain.
3. NP_001229536.1 neural cell adhesion molecule 1 isoform 5 precursor: "Transcript Variant: This variant (5) represents the longest transcript and encodes the longest protein (isoform 5)." Conserved Domains summary: cd05865 Location: 20 → 115 Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, smart00409 Location: 124 → 190 IG; Immunoglobulin, pfam13927 Location: 447 → 519 Ig_3; Immunoglobulin domain cl11960 Location: 306 → 438 Ig; Immunoglobulin domain.
4. NP_001229537.1 neural cell adhesion molecule 1 isoform 4 precursor: "Transcript Variant: This variant (4) lacks 2 alternate in-frame exons and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 5." Conserved Domains summary: cd05865 Location: 20 → 115 Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, cd05869 Location: 306 → 402 Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM), smart00409 Location: 124 → 190 IG; Immunoglobulin, pfam13927 Location: 411 → 483 Ig_3; Immunoglobulin domain. cl11960 Location: 211 → 307 Ig; Immunoglobulin domain.
5. NP_851996.2 neural cell adhesion molecule 1 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 5. The resulting protein (isoform 2) is shorter compared to isoform 5." Conserved Domains summary: cd05865 Location: 20 → 115 Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, cd05869 Location: 306 → 412 Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM), smart00409 Location: 124 → 190 IG; Immunoglobulin, pfam13927 Location: 421 → 493 Ig_3; Immunoglobulin domain, and cl11960 Location: 211 → 307 Ig; Immunoglobulin domain.

Gene ID: 4685 is NCAM2 neural cell adhesion molecule 2 on 21q21.1: "The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons."

1. NP_001339520.1 neural cell adhesion molecule 2 isoform 1 precursor [variant 1], Conserved Domains summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 401 → 479 Ig_3; Immunoglobulin domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
2. NP_001339521.1 neural cell adhesion molecule 2 isoform 3 [variant 3], Conserved Domains summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 426 → 504 Ig_3; Immunoglobulin domain, and cl11960 Location: 233 → 326 Ig; Immunoglobulin domain.
3. NP_001339522.1 neural cell adhesion molecule 2 isoform 4 precursor [variant 4], Conserved Domains summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 401 → 479 Ig_3; Immunoglobulin domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
4. NP_001339523.1 neural cell adhesion molecule 2 isoform 5 precursor [variant 5], Conserved Domains summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 401 → 479 Ig_3; Immunoglobulin domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
5. NP_001339524.1 neural cell adhesion molecule 2 isoform 6 precursor [variant 6], Conserved Domains summary: cd05870 Location: 158 → 255 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 259 → 337 Ig_3; Immunoglobulin domain, and cl11960 Location: 66 → 159 Ig; Immunoglobulin domain.
6. NP_001339525.1 neural cell adhesion molecule 2 isoform 7 precursor [variant 7], Conserved Domains summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397, Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 401 → 479 Ig_3; Immunoglobulin domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
7. NP_001339526.1 neural cell adhesion molecule 2 isoform 8 [variant 8], Conserved Domains summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 147 → 212 Ig_3; Immunoglobulin domain, cl11960 Location: 233 → 326 Ig; Immunoglobulin domain.
8. NP_004531.2 neural cell adhesion molecule 2 isoform 2 precursor [variant 2], Conserved Domains summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 414 → 482 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 308 → 395 IG_like; Immunoglobulin like, pfam07679 Location: 22 → 111 I-set; Immunoglobulin I-set domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
9. XP_024307849.1 neural cell adhesion molecule 2 isoform X5 Conserved Domains (6) summary: cd05866 Location: 21 → 112 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 300 → 397 Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), pfam13927 Location: 401 → 479 Ig_3; Immunoglobulin domain, and cl11960 Location: 208 → 301 Ig; Immunoglobulin domain.
10. XP_011527878.1 neural cell adhesion molecule 2 isoform X1 Conserved Domains (8) summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 439 → 507 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 333 → 420 IG_like; Immunoglobulin like, pfam07679 Location: 47 → 136 I-set; Immunoglobulin I-set domain, and cl11960 Location:233 → 326 Ig; Immunoglobulin domain.
11. XP_016883845.1 neural cell adhesion molecule 2 isoform X6 Conserved Domains (7) summary: cd05870 Location: 136 → 233 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 250 → 318 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 144 → 231 IG_like; Immunoglobulin like, pfam07679 Location: 51 → 134 I-set; Immunoglobulin I-set domain, and cl11960 Location: 44 → 137 Ig; Immunoglobulin domain.
12. XP_011527877.1 neural cell adhesion molecule 2 isoform X1 Conserved Domains (8) summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location:439 → 507 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 333 → 420 IG_like; Immunoglobulin like, pfam07679 Location: 47 → 136 I-set; Immunoglobulin I-set domain, and cl11960 Location: 233 → 326 Ig; Immunoglobulin domain.
13. XP_011527883.1 neural cell adhesion molecule 2 isoform X3 Conserved Domains (8) summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2 cd05870 Location: 325 → 422 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 439 → 507 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 333 → 420 IG_like; Immunoglobulin like, pfam07679 Location: 47 → 136 I-set; Immunoglobulin I-set domain, and cl11960 Location: 233 → 326 Ig; Immunoglobulin domain.
14. XP_011527882.1 neural cell adhesion molecule 2 isoform X2 Conserved Domains (8) summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 439 → 507 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 333 → 420 IG_like; Immunoglobulin like, pfam07679 Location: 47 → 136 I-set; Immunoglobulin I-set domain, and cl11960 Location:233 → 326 Ig; Immunoglobulin domain.
15. XP_011527884.1 neural cell adhesion molecule 2 isoform X4 Conserved Domains (8) summary: cd05866 Location: 46 → 137 Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2, cd05870 Location: 325 → 422 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 439 → 507 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 333 → 420 IG_like; Immunoglobulin like, pfam07679 Location: 47 → 136 I-set; Immunoglobulin I-set domain, cl11960 Location: 233 → 326 Ig; Immunoglobulin domain.
16. XP_011527887.1 neural cell adhesion molecule 2 isoform X6 Conserved Domains (7) summary: cd05870 Location: 136 → 233 Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM), smart00408 Location: 250 → 318 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 144 → 231 IG_like; Immunoglobulin like, pfam07679 Location: 51 → 134 I-set; Immunoglobulin I-set domain and cl11960 Location: 44 → 137 Ig; Immunoglobulin domain.

Gene ID: 4897 is NRCAM neuronal cell adhesion molecule on 7q31.1: "Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms."

1. NP_001032209.1 neuronal cell adhesion molecule isoform A precursor: "Transcript Variant: This variant (1), as well as variant 7, encodes isoform A." Conserved Domains summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
2. NP_001180511.1 neuronal cell adhesion molecule isoform D precursor: "Transcript Variant: This variant (4) differs in the 5' UTR and lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform D) is shorter than isoform A. Variants 4 and 12-14 all encode the same isoform (D)." Conserved Domains summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
3. NP_001180512.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (5) differs in the 5' UTR and lacks three in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform E) is shorter than isoform A. Variants 5 and 15-22 all encode the same isoform (E)." Conserved Domains summary: cd05868 Location:356 → 431 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location:64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location:450 → 513 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 342 → 430 I-set; Immunoglobulin I-set domain, cl11960 Location: 269 → 339 Ig; Immunoglobulin domain.
4. NP_001180513.1 neuronal cell adhesion molecule isoform F precursor: "Transcript Variant: This variant (6) differs in the 5' UTR and lacks four in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform F) is shorter than isoform A. Variants 6 and 23 both encode the same isoform (F)." Conserved Domains summary: cd05868 Location: 356 → 431 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 450 → 513 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location:342 → 430 I-set; Immunoglobulin I-set domain, and cl11960 Location: 269 → 339 Ig; Immunoglobulin domain.
5. NP_001358048.1 neuronal cell adhesion molecule isoform P precursor, variant 45.
6. NP_001358051.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (15), as well as variants 5 and 16-22, encodes isoform E."
7. NP_001358052.1 neuronal cell adhesion molecule isoform G precursor: "Transcript Variant: This variant (24), as well as variant 25, encodes isoform G."
8. NP_001358053.1 neuronal cell adhesion molecule isoform H precursor: "Transcript Variant: This variant (26), as well as variants 27 and 28, encodes isoform H."
9. NP_001358054.1 neuronal cell adhesion molecule isoform I: "Transcript Variant: This variant (29), as well as variant 30, encodes isoform I."
10. NP_001358055.1 neuronal cell adhesion molecule isoform H precursor: "Transcript Variant: This variant (27), as well as variants 26 and 28, encodes isoform H."
11. NP_001358056.1 neuronal cell adhesion molecule isoform Q precursor, variant 46.
12. NP_001358057.1 neuronal cell adhesion molecule isoform D precursor: "Transcript Variant: This variant (12), as well as variants 4, 13, and 14, encodes isoform D."
13. NP_001358058.1 neuronal cell adhesion molecule isoform J precursor: "Transcript Variant: This variant (31), as well as variant 32, encodes isoform J."
14. NP_001358059.1 neuronal cell adhesion molecule isoform K precursor: "Transcript Variant: This variant (33), as well as variants 34 and 35, encodes isoform K."
15. NP_001358060.1 neuronal cell adhesion molecule isoform A precursor: "Transcript Variant: This variant (7), as well as variant 1, encodes isoform A."
16. NP_001358061.1 neuronal cell adhesion molecule isoform J precursor: "Transcript Variant: This variant (32), as well as variant 31, encodes isoform J."
17. NP_001358062.1 neuronal cell adhesion molecule isoform B precursor: "Transcript Variant: This variant (8), as well as variants 2, 9, 10, and 11, encodes isoform B."
18. NP_001358063.1 neuronal cell adhesion molecule isoform R precursor, variant 47.
19. NP_001358064.1 neuronal cell adhesion molecule isoform S precursor, variant 48.
20. NP_001358065.1 neuronal cell adhesion molecule isoform T precursor, variant 49.
21. NP_001358066.1 neuronal cell adhesion molecule isoform U, variant 50.
22. NP_001358067.1 neuronal cell adhesion molecule isoform V precursor, variant 51.
23. NP_001358068.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (16), as well as variants 5, 15, and 17-22, encodes isoform E."
24. NP_001358069.1 neuronal cell adhesion molecule isoform W precursor, variant 52.
25. NP_001358070.1 neuronal cell adhesion molecule isoform X precursor, variant 53.
26. NP_001358071.1 neuronal cell adhesion molecule isoform Y, variant 54.
27. NP_001358072.1 neuronal cell adhesion molecule isoform L: "Transcript Variant: This variant (36), as well as variant 37, encodes isoform L."
28. NP_001358073.1 neuronal cell adhesion molecule isoform D precursor: "Transcript Variant: This variant (13), as well as variants 4, 12, and 14, encodes isoform D."
29. NP_001358074.1 neuronal cell adhesion molecule isoform Z precursor, variant 55.
30. NP_001358075.1 neuronal cell adhesion molecule isoform aa precursor, variant 56.
31. NP_001358076.1 neuronal cell adhesion molecule isoform I: "Transcript Variant: This variant (30), as well as variant 29, encodes isoform I."
32. NP_001358077.1 neuronal cell adhesion molecule isoform M: "Transcript Variant: This variant (38), as well as variants 39 and 40, encodes isoform M."
33. NP_001358078.1 neuronal cell adhesion molecule isoform G precursor: "Transcript Variant: This variant (25), as well as variant 24, encodes isoform G."
34. NP_001358079.1 neuronal cell adhesion molecule isoform bb precursor, variant 57.
35. NP_001358080.1 neuronal cell adhesion molecule isoform B precursor: "Transcript Variant: This variant (9), as well as variants 2, 8, 10, and 11, encodes isoform B."
36. NP_001358081.1 neuronal cell adhesion molecule isoform K precursor: "Transcript Variant: This variant (34), as well as variants 33 and 35, encodes isoform K."
37. NP_001358082.1 neuronal cell adhesion molecule isoform N precursor: "Transcript Variant: This variant (41), as well as variant 42, encodes isoform N."
38. NP_001358083.1 neuronal cell adhesion molecule isoform O precursor: "Transcript Variant: This variant (43), as well as variant 44, encodes isoform O."
39. NP_001358084.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (17), as well as variants 5, 15, 16, and 18-22, encodes isoform E."
40. NP_001358085.1 neuronal cell adhesion molecule isoform cc precursor: "Transcript Variant: This variant (58) encodes the longest isoform (cc)."
41. NP_001358086.1 neuronal cell adhesion molecule isoform dd precursor, variant 59.
42. NP_001358087.1 neuronal cell adhesion molecule isoform ee precursor, variant 60.
43. NP_001358088.1 neuronal cell adhesion molecule isoform ll precursor, variant 68.
44. NP_001358089.1 neuronal cell adhesion molecule isoform ff precursor, variant 61.
45. NP_001358090.1 neuronal cell adhesion molecule isoform N precursor: "Transcript Variant: This variant (42), as well as variant 41, encodes isoform N."
46. NP_001358091.1 neuronal cell adhesion molecule isoform F precursor: "Transcript Variant: This variant (23), as well as variant 6, encodes isoform F."
47. NP_001358092.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (18), as well as variants 5, 15-17, and 19-22, encodes isoform E."
48. NP_001358093.1 neuronal cell adhesion molecule isoform L: "Transcript Variant: This variant (37), as well as variant 36, encodes isoform L."
49. NP_001358094.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (19), as well as variants 5, 15-18, and 20-22, encodes isoform E."
50. NP_001358095.1 neuronal cell adhesion molecule isoform O precursor: "Transcript Variant: This variant (44), as well as variant 43, encodes isoform O."
51. NP_001358096.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (20), as well as variants 5, 15-19, 21, and 22, encodes isoform E."
52. NP_001358097.1 neuronal cell adhesion molecule isoform D precursor: "Transcript Variant: This variant (14), as well as variants 4, 12, and 13, encodes isoform D."
53. NP_001358098.1 neuronal cell adhesion molecule isoform gg precursor, variant 62.
54. NP_001358099.1 neuronal cell adhesion molecule isoform hh, variant 63.
55. NP_001358100.1 neuronal cell adhesion molecule isoform B precursor: "Transcript Variant: This variant (10), as well as variants 2, 8, 9, and 11, encodes isoform B."
56. NP_001358101.1 neuronal cell adhesion molecule isoform H precursor: "Transcript Variant: This variant (28), as well as variants 26 and 27, encodes isoform H."
57. NP_001358102.1 neuronal cell adhesion molecule isoform ii precursor, variant 64.
58. NP_001358103.1 neuronal cell adhesion molecule isoform jj precursor, variant 65.
59. NP_001358104.1 neuronal cell adhesion molecule isoform kk precursor, variant 66.
60. NP_001358105.1 neuronal cell adhesion molecule isoform K precursor: "Transcript Variant: This variant (35), as well as variants 33 and 34, encodes isoform K."
61. NP_001358106.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (21), as well as variants 5, 15-20, and 22, encodes isoform E."
62. NP_001358107.1 neuronal cell adhesion molecule isoform B precursor: "Transcript Variant: This variant (11), as well as variants 2 and 8-10, encodes isoform B."
63. NP_001358108.1 neuronal cell adhesion molecule isoform M: "Transcript Variant: This variant (39), as well as variants 38 and 40, encodes isoform M."
64. NP_001358109.1 neuronal cell adhesion molecule isoform M: "Transcript Variant: This variant (40), as well as variants 38 and 39, encodes isoform M."
65. NP_001358110.1 neuronal cell adhesion molecule isoform E precursor: "Transcript Variant: This variant (22), as well as variants 5 and 15-21, encodes isoform E."
66. NP_001358111.1 neuronal cell adhesion molecule isoform mm precursor, variant 67.
67. NP_005001.3 neuronal cell adhesion molecule isoform B precursor: "Transcript Variant: This variant (2) differs in the 5' UTR and lacks five in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform B) is shorter than isoform A. Variants 2 and 8-11 all encode the same isoform (B)." Conserved Domains summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location:58 → 134 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 463 → 526 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 47 → 129 IG_like; Immunoglobulin like, pfam07679 Location: 355 → 443 I-set; Immunoglobulin I-set domain, and cl11960 Location: 282 → 352 Ig; Immunoglobulin domain.
68. XP_011514570.1 neuronal cell adhesion molecule isoform X21 Conserved Domains (8) summary: cd05868 Location: 279 → 354 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), smart00408 Location: 373 → 436 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 57 → 142 IG_like; Immunoglobulin like, pfam07679 Location: 265 → 353 I-set; Immunoglobulin I-set domain, and cl11960 Location: 192 → 262 Ig; Immunoglobulin domain.
69. XP_024302547.1 neuronal cell adhesion molecule isoform X41 Conserved Domains (8) summary: cd05868 Location: 350 → 425 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 58 → 134 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location: 428 → 504 Ig_3; Immunoglobulin domain, cl11960 Location: 263 → 333 Ig; Immunoglobulin domain, cl28434 Location: 523 → 608 I-set; Immunoglobulin I-set domain.
70. XP_024302546.1 neuronal cell adhesion molecule isoform X40 Conserved Domains (8) summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 58 → 134 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location:447 → 523 Ig_3; Immunoglobulin domain, and cl11960 Location: 282 → 352 Ig; Immunoglobulin domain, cl28434 Location: 542 → 627 I-set; Immunoglobulin I-set domain.
71. XP_011514563.1 neuronal cell adhesion molecule isoform X9 Conserved Domains (9) summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 58 → 134 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 463 → 526 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 47 → 133 IG_like; Immunoglobulin like, pfam07679 Location: 355 → 443 I-set; Immunoglobulin I-set domain, pfam00041 Location: 832 → 924 fn3; Fibronectin type III domain, and cl11960 Location: 282 → 352 Ig; Immunoglobulin domain.
72. XP_024302545.1 neuronal cell adhesion molecule isoform X37 Conserved Domains (8) summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 58 → 134 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location: 447 → 523 Ig_3; Immunoglobulin domain, cl11960 Location: 282 → 352 Ig; Immunoglobulin domain, and cl28434 Location: 542 → 627 I-set; Immunoglobulin I-set domain.
73. XP_011514559.1 neuronal cell adhesion molecule isoform X4 Conserved Domains (9) summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 58 → 134 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 463 → 526 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 47 → 133 IG_like; Immunoglobulin like, pfam07679, Location: 355 → 443 I-set; Immunoglobulin I-set domain, and cl11960 Location: 282 → 352 Ig; Immunoglobulin domain.
74. XP_024302541.1 neuronal cell adhesion molecule isoform X15 Conserved Domains (8) summary: cd05868 Location: 356 → 431 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location: 434 → 510 Ig_3; Immunoglobulin domain, and cl11960 Location: 269 → 339 Ig; Immunoglobulin domain, and cl28434 Location: 529 → 614 I-set; Immunoglobulin I-set domain.
75. XP_024302543.1 neuronal cell adhesion molecule isoform X31 Conserved Domains (8) summary: cd05868 Location: 356 → 431 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location: 434 → 510 Ig_3; Immunoglobulin domain, cl11960 Location: 269 → 339 Ig; Immunoglobulin domain, and cl28434 Location: 529 → 614 I-set; Immunoglobulin I-set domain.
76. XP_011514564.1 neuronal cell adhesion molecule isoform X11 Conserved Domains (9) summary: cd05868 Location: 356 → 431 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 450 → 513 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 342 → 430 I-set; Immunoglobulin I-set domain, and cl11960 Location: 269 → 339 Ig; Immunoglobulin domain.
77. XP_011514561.1 neuronal cell adhesion molecule isoform X6 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
78. XP_006716077.1 neuronal cell adhesion molecule isoform X25 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
79. XP_006716070.1 neuronal cell adhesion molecule isoform X8 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 135 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
80. XP_006716075.1 neuronal cell adhesion molecule isoform X20 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
81. XP_006716066.1 neuronal cell adhesion molecule isoform X2 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule) cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, 'pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
82. XP_011514572.1 neuronal cell adhesion molecule isoform X26 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
83. XP_011514571.1 neuronal cell adhesion molecule isoform X23 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
84. XP_011514569.1 neuronal cell adhesion molecule isoform X19 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
85. XP_011514555.1 neuronal cell adhesion molecule isoform X1 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
86. XP_011514560.1 neuronal cell adhesion molecule isoform X4 Conserved Domains (9) summary: cd05868 Location: 369 → 444 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule) cd05874 Location: 58 → 134 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 463 → 526 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 47 → 133 IG_like; Immunoglobulin like, pfam07679 Location: 355 → 443 I-set; Immunoglobulin I-set domain, and cl11960 Location: 282 → 352 Ig; Immunoglobulin domain.
87. XP_011514557.1 neuronal cell adhesion molecule isoform X1 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 139 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
88. XP_024302548.1 neuronal cell adhesion molecule isoform X42 Conserved Domains (8) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), pfam13927 Location: 453 → 529 Ig_3; Immunoglobulin domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain, and cl28434 Location: 548 → 633 I-set; Immunoglobulin I-set domain.
89. XP_011514567.1 neuronal cell adhesion molecule isoform X17 Conserved Domains (9) summary: cd05868 Location: 375 → 450 Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 135 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.
90. XP_011514568.1 neuronal cell adhesion molecule isoform X18 Conserved Domains (9) summary: cd05868 Location: 375 → 450, Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule), cd05874 Location: 64 → 140 Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule), smart00408 Location: 469 → 532 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 53 → 135 IG_like; Immunoglobulin like, pfam07679 Location: 361 → 449 I-set; Immunoglobulin I-set domain, and cl11960 Location: 288 → 358 Ig; Immunoglobulin domain.

Gene ID: 4978 is OPCML opioid binding protein/cell adhesion molecule like on 11q25: "This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed."

1. NP_001012393.1 opioid-binding protein/cell adhesion molecule isoform b precursor: "Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (b) is shorter and has a distinct N-terminus compared to isoform c. The encoded isoform (b) may undergo proteolytic processing similar to isoform a." Conserved Domains summary: smart00409 Location: 227 → 305 IG; Immunoglobulin, pfam13927 Location: 128 → 199 Ig_3; Immunoglobulin domain, cl11960 Location: 37 → 125 Ig; Immunoglobulin domain.
2. NP_001306032.1 opioid-binding protein/cell adhesion molecule isoform c precursor: "Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c). The encoded isoform (c) may undergo proteolytic processing similar to isoform a." Conserved Domains summary: smart00410 Location: 234 → 312 IG_like; Immunoglobulin like, pfam13927 Location: 135 → 206 Ig_3; Immunoglobulin domain, and cl11960 Location: 44 → 132 Ig; Immunoglobulin domain.
3. NP_001306033.1 opioid-binding protein/cell adhesion molecule isoform d: "Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (d) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform c." Conserved Domains summary: smart00409 Location: 2 → 32 IG; Immunoglobulin, smart00410 Location: 134 → 212 IG_like; Immunoglobulin like, and pfam13927 Location: 35 → 106 Ig_3; Immunoglobulin domain.
4. NP_001306034.1 opioid-binding protein/cell adhesion molecule isoform e: "Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream translation start site, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (e) is shorter and lacks a predicted signal peptide compared to isoform c." Conserved Domains summary: smart00409 Location: 193 → 271 IG; Immunoglobulin, pfam13927 Location: 94 → 165 Ig_3; Immunoglobulin domain, and cl11960 Location: 3 → 91 Ig; Immunoglobulin domain.
5. NP_001306035.1 opioid-binding protein/cell adhesion molecule isoform f precursor: "Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (f) may undergo proteolytic processing similar to isoform a." Conserved Domains summary: smart00409 Location: 233 → 311 IG; Immunoglobulin, pfam13927 Location: 135 → 205 Ig_3; Immunoglobulin domain, and cl11960 Location: 44 → 132 Ig; Immunoglobulin domain.
6. NP_002536.1 opioid-binding protein/cell adhesion molecule isoform a preproprotein: "Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (a) is shorter than isoform c." Conserved Domains summary: smart00409 Location: 234 → 312 IG; Immunoglobulin, pfam13927 Location: 135 → 206 Ig_3; Immunoglobulin domain, and cl11960 Location: 44 → 132 Ig; Immunoglobulin domain.
7. XP_011541158.1 opioid-binding protein/cell adhesion molecule isoform X2 Conserved Domains (3) summary: smart00409 Location: 193 → 271 IG; Immunoglobulin, pfam13927 Location: 94 → 165 Ig_3; Immunoglobulin domain, and cl11960 Location: 3 → 91 Ig; Immunoglobulin domain.
8. XP_006718909.1 opioid-binding protein/cell adhesion molecule isoform X1 Conserved Domains (4) summary: smart00408 Location: 142 → 198 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 226 → 304 IG_like; Immunoglobulin like, pfam00047 Location:222 → 303 ig; Immunoglobulin domain, and cl11960 Location: 37 → 125 Ig; Immunoglobulin domain.

Gene ID: 5175 is PECAM1 platelet and endothelial cell adhesion molecule 1 on 17q23.3: "The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation."

1. NP_000433.4 platelet endothelial cell adhesion molecule precursor, Conserved Domains summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like and pfam13895 Location: 327 → 404 Ig_2; Immunoglobulin domain.
2. XP_011523191.1 platelet endothelial cell adhesion molecule isoform X1 Conserved Domains (2) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 327 → 404 Ig_2; Immunoglobulin domain.
3. XP_016880229.1 platelet endothelial cell adhesion molecule isoform X4 Conserved Domains (4) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 328 → 404 Ig_2; Immunoglobulin domain, pfam13927 Location: 507 → 576 Ig_3; Immunoglobulin domain, cl11960 Location: 43 → 127 Ig; Immunoglobulin domain.
4. XP_011523192.1 platelet endothelial cell adhesion molecule isoform X1 Conserved Domains (2) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 327 → 404 Ig_2; Immunoglobulin domain.
5. XP_016880227.1 platelet endothelial cell adhesion molecule isoform X1 Conserved Domains (2) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, and pfam13895 Location: 327 → 404 Ig_2; Immunoglobulin domain.
6. XP_005276939.1 platelet endothelial cell adhesion molecule isoform X5 Conserved Domains (4) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 328 → 404 Ig_2; Immunoglobulin domain, pfam13927 Location: 507 → 576 Ig_3; Immunoglobulin domain, cl11960 Location: 43 → 127 Ig; Immunoglobulin domain.
7. XP_005276938.1 platelet endothelial cell adhesion molecule isoform X4 Conserved Domains (4) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 328 → 404 Ig_2; Immunoglobulin domain, pfam13927 Location: 507 → 576 Ig_3; Immunoglobulin domain, and cl11960 Location: 43 → 127 Ig; Immunoglobulin domain.
8. XP_005276937.1 platelet endothelial cell adhesion molecule isoform X2 Conserved Domains (4) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 328 → 404 Ig_2; Immunoglobulin domain, pfam13927 Location: 507 → 576 Ig_3; Immunoglobulin domain, and cl11960 Location: 43 → 127 Ig; Immunoglobulin domain.
9. XP_005276940.1 platelet endothelial cell adhesion molecule isoform X6 Conserved Domains (4) summary: smart00410 Location: 43 → 127 IG_like; Immunoglobulin like, pfam13895 Location: 328 → 404 Ig_2; Immunoglobulin domain, pfam13927 Location: 507 → 576 Ig_3; Immunoglobulin domain, and cl11960 Location: 43 → 127 Ig; Immunoglobulin domain.

Gene ID: 7412 is VCAM1 vascular cell adhesion molecule 1 on 1p21.2: "This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene."

1. NP_001069.1 vascular cell adhesion protein 1 isoform a precursor: "Transcript Variant: This variant (1) encodes the predominant, full-length isoform (a)." Conserved Domains summary: cd07689 Location: 116 → 214 Ig_VCAM-1; Immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar domains, smart00408 Location: 238 → 298 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 33 → 112 IG; Immunoglobulin, smart00410 Location: 519 → 596 IG_like; Immunoglobulin like, and cl28434 Location: 313 → 399 I-set; Immunoglobulin I-set domain.
2. NP_001186763.1 vascular cell adhesion protein 1 isoform c precursor: "Transcript Variant: This variant (3) lacks an in-frame segment in the CDS compared to transcript variant 1. The resulting isoform (c) lacks an internal segment compared to isoform a." Conserved Domains summary: cd07689 Location: 54 → 152 Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins, smart00408 Location: 176 → 236 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 259 → 337, IG_like; Immunoglobulin like, and pfam13927 Location: 546 → 610 Ig_3; Immunoglobulin domain.
3. NP_542413.1 vascular cell adhesion protein 1 isoform b precursor: "Transcript Variant: This variant (2) lacks an in-frame exon in the CDS compared to transcript variant 1. The resulting isoform (b) lacks an internal segment compared to isoform a." Conserved Domains summary: cd07689 Location: 116 → 214 Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins, smart00408 Location: 238 → 298 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 33 → 112 IG_like; Immunoglobulin like, pfam00047 Location: 35 → 97 ig; Immunoglobulin domain, and pfam13927 Location: 516 → 580 Ig_3; Immunoglobulin domain.

Gene ID: 8174 is MADCAM1 mucosal vascular addressin cell adhesion molecule 1 on 19p13.3: "The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined."

1. NP_570116.2 mucosal addressin cell adhesion molecule 1 isoform a precursor: "Transcript Variant: This variant (1) is the longer, predominant transcript and encodes the longer isoform (a)." Conserved Domains summary: smart00410 Location: 33 → 111 IG_like; Immunoglobulin like, pfam09085 Location: 113 → 221 Adhes-Ig_like; Adhesion molecule, immunoglobulin-like, and cl11960 Location: 26 → 109 Ig; Immunoglobulin domain.
2. NP_570118.1 mucosal addressin cell adhesion molecule 1 isoform b precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) that lacks an internal segment, compared to isoform a." Conserved Domains summary: smart00410 Location: 33 → 111 IG_like; Immunoglobulin like, pfam09085 Location: 113 → 221 Adhes-Ig_like; Adhesion molecule, immunoglobulin-like, and cl11960 Location: 28 → 109 Ig; Immunoglobulin domain.

Gene ID: 10752 is CHL1 cell adhesion molecule L1 like on 3p26.3: "The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants."

1. NP_001240316.1 neural cell adhesion molecule L1-like protein isoform 2 precursor: "Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1." Conserved Domains summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location:129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
2. NP_001240317.1 neural cell adhesion molecule L1-like protein isoform 3 precursor: "Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1." Conserved Domains summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
3. NP_006605.2 neural cell adhesion molecule L1-like protein isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)." Conserved Domains summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, 'cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location:55 → 126 Ig; Immunoglobulin domain.
4. XP_016861055.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
5. XP_016861061.1 neural cell adhesion molecule L1-like protein isoform X3 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
6. XP_006713002.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
7. XP_016861062.1 neural cell adhesion molecule L1-like protein isoform X3 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
8. XP_016861058.1 neural cell adhesion molecule L1-like protein isoform X2 Conserved Domains (9) summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
9. XP_016861056.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
10. XP_016861060.1 neural cell adhesion molecule L1-like protein isoform X2 Conserved Domains (9) summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
11. XP_006713001.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
12. XP_011531598.1 neural cell adhesion molecule L1-like protein isoform X3 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
13. XP_011531596.1 neural cell adhesion molecule L1-like protein isoform X2 Conserved Domains (9) summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
14. XP_011531594.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
15. XP_011531597.1 neural cell adhesion molecule L1-like protein isoform X2 Conserved Domains (9) summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
16. XP_006713003.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
17. XP_016861059.1 neural cell adhesion molecule L1-like protein isoform X2 Conserved Domains (9) summary: cd00096 Location: 532 → 600 Ig; Immunoglobulin domain, cd04978 Location: 345 → 419 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 258 → 328 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 248 → 327 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.
18. XP_016861057.1 neural cell adhesion molecule L1-like protein isoform X1 Conserved Domains (9) summary: cd00096 Location: 548 → 616 Ig; Immunoglobulin domain, cd04978 Location: 361 → 435 Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related), cd05731 Location: 274 → 344 Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), cd05845 Location: 129 → 223 Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins, smart00410 Location: 264 → 343 IG_like; Immunoglobulin like, and cl11960 Location: 55 → 126 Ig; Immunoglobulin domain.

Gene ID: 23705 is CADM1 cell adhesion molecule 1 aka IGSF4 on 11q23.3.

1. NP_001091987.1 cell adhesion molecule 1 isoform E precursor: "Transcript Variant: This variant (2) lacks three alternate in-frame exons compared to variant 3. The resulting isoform (2, also known as E) has the same N- and C-termini but is shorter compared to isoform A." Conserved Domains summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2, cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), and smart00409 Location: 252 → 330 IG; Immunoglobulin.
2. NP_001287972.1 cell adhesion molecule 1 isoform A precursor: "Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (A)." Conserved Domains summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), smart00408 Location: 259 → 320 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 252 → 330 IG_like; Immunoglobulin like.
3. NP_001287973.1 cell adhesion molecule 1 isoform B precursor: "Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (B) has the same N- and C-termini but is shorter compared to isoform A." Conserved Domains summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), smart00408 Location: 259 → 320 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 252 → 330 IG_like; Immunoglobulin like.
4. NP_001287974.1 cell adhesion molecule 1 isoform C precursor: "Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (C) has the same N- and C-termini but is shorter compared to isoform A." Conserved Domains summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2, cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), and smart00409' Location: 252 → 330 IG; Immunoglobulin.
5. NP_055148.3 cell adhesion molecule 1 isoform D precursor: "Transcript Variant: This variant (1) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (1, also known as D) has the same N- and C-termini but is shorter compared to isoform A." Conserved Domains summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2, cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), and smart00409 Location: 252 → 330 IG; Immunoglobulin.
6. XP_005271551.1 cell adhesion molecule 1 isoform X2 Conserved Domains (4) summary: cd05881 Location: 46 → 140 Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), cd05883 Location: 161 → 242 Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)), smart00408 Location: 259 → 320 IGc2; Immunoglobulin C-2 Type, and smart00410 Location:252 → 330 IG_like; Immunoglobulin like.

Gene ID: 51148 is CERCAM cerebral endothelial cell adhesion molecule on 9q34.11.

1. NP_001273689.1 inactive glycosyltransferase 25 family member 3 isoform b: "Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a."
2. NP_057258.3 inactive glycosyltransferase 25 family member 3 isoform a precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a)."

Gene ID: 57453 is DSCAML1 DS cell adhesion molecule like 1 on 11q23.3: "The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type."

1. NP_001354833.1 Down syndrome cell adhesion molecule-like protein 1 isoform 2 precursor, variant 2.
2. NP_001354834.1 Down syndrome cell adhesion molecule-like protein 1 isoform 3, variant 3.
3. NP_065744.3 Down syndrome cell adhesion molecule-like protein 1 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)."
4. XP_011541219.1 Down syndrome cell adhesion molecule-like protein 1 isoform X1 Conserved Domains (8) summary: cd00096 Location: 627 → 693 Ig; Immunoglobulin domain, cd05734 Location: 719 → 797 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 252 → 313 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 619 → 698 IG_like; Immunoglobulin like, pfam07679 Location: 245 → 323 I-set; Immunoglobulin I-set domain, pfam00041 Location: 1105 → 1191 fn3; Fibronectin type III domain, and cl11960 Location: 815 → 903 Ig; Immunoglobulin domain.
5. XP_011541220.1 Down syndrome cell adhesion molecule-like protein 1 isoform X2 Conserved Domains (8) summary: cd00096 Location: 1231 → 1301 Ig; Immunoglobulin domain, cd05734 Location: 631 → 709 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 164 → 225 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 531 → 610 IG_like; Immunoglobulin like, pfam07679 Location: 157 → 235 I-set; Immunoglobulin I-set domain, and cl11960 Location: 727 → 815 Ig; Immunoglobulin domain.
6. XP_011541222.1 Down syndrome cell adhesion molecule-like protein 1 isoform X4 Conserved Domains (8) summary: cd00096 Location: 797 → 867 Ig; Immunoglobulin domain, cd05734 Location: 197 → 275 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 9 → 67 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 97 → 176 IG_like; Immunoglobulin like, pfam07679 Location: 180 → 275 I-set; Immunoglobulin I-set domain, pfam00041 Location: 583 → 669 fn3; Fibronectin type III domain, and cl11960 Location: 293 → 381 Ig; Immunoglobulin domain.
7. XP_011541221.1 Down syndrome cell adhesion molecule-like protein 1 isoform X3 Conserved Domains (8) summary: cd00096 Location: 880 → 950 Ig; Immunoglobulin domain, cd05734 Location: 280 → 358 Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM), smart00408 Location: 92 → 150 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 180 → 259 IG_like; Immunoglobulin like, pfam07679 Location: 263 → 358 I-set; Immunoglobulin I-set domain, andcl11960 Location: 376 → 464 Ig; Immunoglobulin domain.
8. XP_011541226.1 Down syndrome cell adhesion molecule-like protein 1 isoform X6 Conserved Domains (5) summary: cd00096 Location: 524 → 594 Ig; Immunoglobulin domain, pfam07679 Location: 8 → 101 I-set; Immunoglobulin I-set domain, pfam00041 Location: 310 → 396 fn3; Fibronectin type III domain, and cl11960 Location: 20 → 108 Ig; Immunoglobulin domain.
9. XP_011541223.1 Down syndrome cell adhesion molecule-like protein 1 isoform X5 Conserved Domains (5) summary: cd00096 Location: 598 → 668 Ig; Immunoglobulin domain, cd00063 Location:675 → 765, pfam07679 Location: 82 → 175 I-set; Immunoglobulin I-set domain, and cl11960 Location: 94 → 182 Ig; Immunoglobulin domain.
10. XP_011541227.1 Down syndrome cell adhesion molecule-like protein 1 isoform X7 Conserved Domains (5) summary: cd00096 Location: 518 → 588 Ig; Immunoglobulin domain, pfam07679 Location: 2 → 95 I-set; Immunoglobulin I-set domain, and cl11960 Location: 14 → 102 Ig; Immunoglobulin domain.

Gene ID: 57863 is CADM3 cell adhesion molecule 3 on 1q23.2: "The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene."

1. NP_001120645.1 cell adhesion molecule 3 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1." Conserved Domains summary: smart00294 Location: 354 → 369 4.1m; putative band 4.1 homologues' binding motif, cd05882 Location: 32 → 126 Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), cd07705 Location: 147 → 229 Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), smart00410 Location: 245 → 316 IG_like; Immunoglobulin like, and pfam13895 Location: 237 → 302 Ig_2; Immunoglobulin domain.
2. NP_001333439.1 cell adhesion molecule 3 isoform 3 precursor: "Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1."
3. NP_067012.1 cell adhesion molecule 3 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)." Conserved Domains summary: cd05882 Location: 66 → 160 Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), cd07705 Location: 181 → 263 Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), smart00410, Location: 279 → 350 IG_like; Immunoglobulin like, and pfam13895 Location: 271 → 336 Ig_2; Immunoglobulin domain.
4. XP_024304528.1 cell adhesion molecule 3 isoform X1 Conserved Domains (4) summary: cd05882 Location: 115 → 209 Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), cd07705 Location: 230 → 312 Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3)), and smart00410 Location: 328 → 399 IG_like; Immunoglobulin like.

Gene ID: 90952 is ESAM endothelial cell adhesion molecule on 11q24.2.

1. NP_620411.2 endothelial cell-selective adhesion molecule precursor, Conserved Domains summary: smart00410 Location: 166 → 241 IG_like; Immunoglobulin like and pfam07686 Location: 40 → 150 V-set; Immunoglobulin V-set domain.

Gene ID: 199731 is CADM4 cell adhesion molecule 4 aka immunoglobulin superfamily member 4C on 19q13.31.

1. NP_660339.1 cell adhesion molecule 4 precursor, Conserved Domains summary: pfam13927 Location: 224 → 295 Ig_3; Immunoglobulin domain and cl11960 Location: 140 → 220 Ig; Immunoglobulin domain.
2. XP_016881941.1 cell adhesion molecule 4 isoform X1 Conserved Domains (5) summary: cd05885 Location: 121 → 201 Ig2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4)), smart00408 Location: 218 → 279 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 212 → 289 IG_like; Immunoglobulin like, and cl11960 Location: 10 → 101 Ig; Immunoglobulin domain.
3. XP_005258677.1 cell adhesion molecule 4 isoform X2 Conserved Domains (3) summary: smart00408 Location: 237 → 298 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 231 → 308 IG_like; Immunoglobulin like, and cl11960 Location: 140 → 220 Ig; Immunoglobulin domain.

Gene ID: 220296 is HEPACAM hepatic and glial cell adhesion molecule on 11q24.2: "The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene."

1. NP_689935.2 hepatocyte cell adhesion molecule precursor, Conserved Domains summary: smart00410 Location: 154 → 235 IG_like; Immunoglobulin like, pfam07686 Location: 41 → 141 V-set; Immunoglobulin V-set domain, and pfam13895 Location: 150 → 235 Ig_2; Immunoglobulin domain.
2. XP_005271506.1 hepatocyte cell adhesion molecule isoform X2 Conserved Domains (3) summary: smart00410 Location: 154 → 235 IG_like; Immunoglobulin like, pfam07686 Location: 41 → 141 V-set; Immunoglobulin V-set domain, and pfam13895 Location: 150 → 235 Ig_2; Immunoglobulin domain.

Gene ID: 221935 is SDK1 sidekick cell adhesion molecule 1 on 7p22.2: "The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants."

1. NP_001073121.1 protein sidekick-1 isoform 2: "Transcript Variant: This variant (2) differs in the 5' UTR, lacks several exons in the 5' coding region, uses a downstream in-frame start codon, and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a significantly shorter N-terminus and a distinct C-terminus, compared to isoform 1."
2. NP_689957.3 protein sidekick-1 isoform 1: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." Conserved Domains summary: cd00096 Location: 404 → 472 Ig; Immunoglobulin domain, smart00408 Location: 312 → 364 IGc2; Immunoglobulin C-2 Type, pfam07679 Location: 480 → 570 I-set; Immunoglobulin I-set domain, pfam00041 Location: 771 → 857 fn3; Fibronectin type III domain, and cl11960 Location: 494 → 570 Ig; Immunoglobulin domain.
3. XP_024302451.1 protein sidekick-1 isoform X2 Conserved Domains (6) summary: pfam07679 Location: 229 → 319 I-set; Immunoglobulin I-set domain, pfam13927 Location: 42 → 113 Ig_3; Immunoglobulin domain, cl11960 Location: 329 → 413 Ig; Immunoglobulin domain, and cl28434 Location: 135 → 224 I-set; Immunoglobulin I-set domain.
4. XP_024302452.1 protein sidekick-1 isoform X3 Conserved Domains (6) summary: pfam07679 Location: 229 → 319 I-set; Immunoglobulin I-set domain, pfam13927 Location: 42 → 113 Ig_3; Immunoglobulin domain, cl11960 Location: 329 → 413 Ig; Immunoglobulin domain, and cl28434 Location: 135 → 224 I-set; Immunoglobulin I-set domain.
5. XP_011513490.1 protein sidekick-1 isoform X4 Conserved Domains (4) summary: pfam07679 Location: 70 → 160 I-set; Immunoglobulin I-set domain, cl11960 Location: 84 → 160 Ig; Immunoglobulin domain.
6. XP_011513491.1 protein sidekick-1 isoform X5 Conserved Domains (4) summary: pfam07679 Location: 70 → 160 I-set; Immunoglobulin I-set domain, pfam00041 Location: 361 → 447 fn3; Fibronectin type III domain, and cl11960 Location: 84 → 160 Ig; Immunoglobulin domain.
7. XP_011513492.1 protein sidekick-1 isoform X6 Conserved Domains (4) summary: pfam07679 Location: 70 → 160 I-set; Immunoglobulin I-set domain, cl11960 Location: 84 → 160 Ig; Immunoglobulin domain.

Gene ID: 253559 is CADM2 cell adhesion molecule 2 aka immunoglobulin superfamily member 4D on 3p12.1: "This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene."

1. NP_001161146.1 cell adhesion molecule 2 isoform 1 precursor [variant 1], Conserved Domains summary: pfam13927 Location: 227 → 300 Ig_3; Immunoglobulin domain, cd05884 Location: 141 → 223 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), and cd07701 Location: 26 → 120 Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)).
2. NP_001161147.1 cell adhesion molecule 2 isoform 2 precursor [variant 2], Conserved Domains summary: pfam13927 Location: 236 → 309 Ig_3; Immunoglobulin domain, cd05884 Location: 150 → 232 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), and cd07701 Location: 35 → 129 Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)).
3. NP_001243431.1 cell adhesion molecule 2 isoform 4 [variant 4], Conserved Domains summary: cd05884 Location: 33 → 115 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), smart00408 Location: 132 → 195 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 131 → 205 IG_like; Immunoglobulin like.
4. NP_001243432.1 cell adhesion molecule 2 isoform 4 [variant 5], Conserved Domains summary: cd05884 Location: 33 → 115 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), smart00408 Location: 132 → 195 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 131 → 205 IG_like; Immunoglobulin like.
5. NP_001243433.1 cell adhesion molecule 2 isoform 5 [variant 6], Conserved Domains summary: cd05884 Location: 33 → 115 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), smart00408 Location: 132 → 195 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 131 → 205 IG_like; Immunoglobulin like.
6. NP_001243434.1 cell adhesion molecule 2 isoform 5 [variant 7], Conserved Domains summary: cd05884 Location: 33 → 115 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), smart00408 Location: 132 → 195 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 131 → 205 IG_like; Immunoglobulin like.
7. NP_001362889.1 cell adhesion molecule 2 isoform 6 precursor [variant 8].
8. NP_001362890.1 cell adhesion molecule 2 isoform 7 precursor [variant 9].
9. NP_001362893.1 cell adhesion molecule 2 isoform 8 precursor [variant 10].
10. NP_001362896.1 cell adhesion molecule 2 isoform 9 precursor [variant 11].
11. NP_001362897.1 cell adhesion molecule 2 isoform 10 precursor [variant 12].
12. NP_694854.2 cell adhesion molecule 2 isoform 3 precursor [variant 3], Conserved Domains summary: pfam13927 Location: 229 → 302 Ig_3; Immunoglobulin domain, cd05884 Location: 143 → 225 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), and cd07701 Location: 28 → 122 Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)).
13. XP_016861552.1 cell adhesion molecule 2 isoform X3 Conserved Domains (5) summary: cd05884 Location: 143 → 225 Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), cd07701 Location: 28 → 122 Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)), smart00408 Location: 242 → 305 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 241 → 315 IG_like; Immunoglobulin like.

Cell adhesion-related genes

Gene ID: 50937 is CDON cell adhesion associated, oncogene regulated on 11q24.2: "This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis."

1. NP_001230526.1 cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longer isoform (1)." Conserved Domains summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
2. NP_001365893.1 cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor [variant 3].
3. NP_058648.4 cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1." Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
4. XP_016873362.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1 Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
5. XP_011541164.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1 Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
6. XP_011541166.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1 Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
7. XP_011541167.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1 Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408 Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.
8. XP_011541165.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1 Conserved Domains (6) summary: cd00096 Location: 422 → 514 Ig; Immunoglobulin domain, smart00408Location: 326 → 387 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 319 → 397 IG_like; Immunoglobulin like, pfam07679 Location: 405 → 517 I-set; Immunoglobulin I-set domain, and cl11960 Location: 30 → 115 Ig; Immunoglobulin domain.

Intercellular adhesion molecule genes

Gene ID: 3383 is ICAM1 intercellular adhesion molecule 1 on 19p13.2.

1. NP_000192.2 intercellular adhesion molecule 1 precursor, Conserved Domains (4) summary: cd05755 Location: 113 → 207 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins, smart00410 Location: 404 → 474 IG_like; Immunoglobulin like, pfam03921 Location: 24 → 110 ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain, and cl11960 Location: 311 → 387 Ig; Immunoglobulin domain.

Gene ID: 3384 is ICAM2 intercellular adhesion molecule 2 on 17q23.3: "The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene."

1. NP_000864.2 intercellular adhesion molecule 2 precursor: "Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein." Conserved Domains (2) summary: cd05755 Location: 112 → 211 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins.
2. NP_001093256.1 intercellular adhesion molecule 2 precursor: "Transcript Variant: This variant (1) represents the longest transcript. All 5 variants encode the same protein." Conserved Domains (2) summary: cd05755 Location: 112 → 211 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins.
3. NP_001093257.1 intercellular adhesion molecule 2 precursor: "Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein." Conserved Domains (2) summary: cd05755 Location: 112 → 211 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins.
4. NP_001093258.1 intercellular adhesion molecule 2 precursor: "Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein." Conserved Domains (2) summary: cd05755 Location: 112 → 211 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins.
5. NP_001093259.1 intercellular adhesion molecule 2 precursor: "Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein." Conserved Domains (2) summary: cd05755 Location: 112 → 211 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins.

Gene ID: 3385 is ICAM3 intercellular adhesion molecule 3 on 19p13.2: "The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms."

1. NP_001307534.1 intercellular adhesion molecule 3 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1." Conserved Domains (3) summary: pfam13895 Location: 221 → 300 Ig_2; Immunoglobulin domain and cl11960 Location: 117 → 211 Ig; Immunoglobulin domain.
2. NP_001307535.1 intercellular adhesion molecule 3 isoform 3: "Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1." Conserved Domains (4) summary: smart00410 Location: 343 → 399 IG_like; Immunoglobulin like, pfam03921 Location: 1 → 37 ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain, pfam13895 Location: 240 → 319 Ig_2; Immunoglobulin domain, and cl11960 Location: 40 → 134 Ig; Immunoglobulin domain.
3. NP_001307537.1 intercellular adhesion molecule 3 isoform 4: "Transcript Variant: This variant (4) retains an intron and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 4 which is shorter than isoform 1." Conserved Domains (3) summary: smart00410 Location: 159 → 215 IG_like; Immunoglobulin like, pfam13895 Location: 56 → 135 Ig_2; Immunoglobulin domain, and cl11960 Location: 160 → 208 Ig; Immunoglobulin domain.
4. NP_002153.2 intercellular adhesion molecule 3 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longest isoform (1)." Conserved Domains (4) summary: pfam13895 Location: 317 → 396 Ig_2; Immunoglobulin domain, cd00096 Location: 420 → 476 Ig; Immunoglobulin domain, and cl11960 Location: 117 → 211 Ig; Immunoglobulin domain.

Gene ID: 3386 is ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) on 19p13.2: "This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms."

1. NP_001034221.1 intercellular adhesion molecule 4 isoform 3 precursor: "Transcript Variant: This variant (3) uses an alternate splice site, which results in a frameshift compared to variant 1. The encoded isoform (3) has the same N-terminus but a distinct C-terminus compared to isoform 1."
2. NP_001535.1 intercellular adhesion molecule 4 isoform 1 precursor: "Transcript Variant: This variant (1) encodes isoform 1." Conserved Domains (2) summary: cl11960 Location: 132 → 217 Ig; Immunoglobulin domain.

Gene ID: 7087 is ICAM5 intercellular adhesion molecule 5, telencephalin on 19p13.2: "The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases."

1. NP_003250.3 intercellular adhesion molecule 5 precursor, Conserved Domains (6) summary: cd05755 Location: 120 → 219 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins, smart00408 Location: 761 → 821 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 759 → 831 IG_like; Immunoglobulin like, pfam03921 Location: 31 → 103 ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain, pfam13895 Location: 325 → 404 Ig_2; Immunoglobulin domain, and cl11960 Location: 512 → 570 Ig; Immunoglobulin domain.
2. XP_011526531.1 intercellular adhesion molecule 5 isoform X1, Conserved Domains (6) summary: cd05755 Location: 120 → 219 Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins, smart00408 Location: 761 → 821 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 759 → 831 IG_like; Immunoglobulin like, pfam03921 Location: 31 → 103 ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain, pfam13895 Location: 325 → 404 Ig_2; Immunoglobulin domain, and cl11960 Location: 512 → 570 Ig; Immunoglobulin domain.

Junction adhesion molecule genes

Gene ID: 50848 is F11R F11 receptor aka JAM1 on 1q23.3: "Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established."

1. NP_001335020.1 junctional adhesion molecule A isoform 6 precursor: "Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1." Conserved Domains (1) summary: pfam13927 Location: 78 → 167 Ig_3; Immunoglobulin domain.
2. NP_001369656.1 junctional adhesion molecule A isoform 7 precursor [variant 7].
3. NP_001369659.1 junctional adhesion molecule A isoform 8 precursor [variant 8].
4. NP_001369662.1 junctional adhesion molecule A isoform 9 precursor [variant 9].
5. NP_001369663.1 junctional adhesion molecule A isoform 10 precursor [variant 10].
6. NP_058642.1 junctional adhesion molecule A isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." Conserved Domains (2) summary: smart00410 Location: 36 → 125 IG_like; Immunoglobulin like and pfam13927 Location: 134 → 216 Ig_3; Immunoglobulin domain.

Gene ID: 58494 is JAM2 junctional adhesion molecule 2 on 21q21.3: "This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene."

1. NP_001257336.1 junctional adhesion molecule B isoform 2 precursor: "Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1." Conserved Domains (2) summary: smart00410 Location: 35 → 94 IG_like; Immunoglobulin like and cd00096 Location: 115 → 189 Ig; Immunoglobulin domain.
2. NP_001257337.1 junctional adhesion molecule B isoform 3 precursor: "Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1, which results in a frame-shift, and a longer isoform (3) with a distinct C-terminus compared to isoform 1." Conserved Domains (2) summary: smart00410 Location: 35 → 130 IG_like; Immunoglobulin like and cd00096 Location: 151 → 225 Ig; Immunoglobulin domain.
3. NP_067042.1 junctional adhesion molecule B isoform 1 precursor: "Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1." Conserved Domains (2) summary: smart00410 Location: 35 → 130 IG_like; Immunoglobulin like and cd00096 Location: 151 → 225 Ig; Immunoglobulin domain.
4. XP_024307892.1 junctional adhesion molecule B isoform X1 Conserved Domains (2) summary: smart00410 Location: 3 → 42 IG_like; Immunoglobulin like and cd00096 Location: 63 → 137 Ig; Immunoglobulin domain.
5. XP_024307891.1 junctional adhesion molecule B isoform X1 Conserved Domains (2) summary: smart00410 Location: 3 → 42 IG_like; Immunoglobulin like and cd00096 Location: 63 → 137 Ig; Immunoglobulin domain.

Gene ID: 83700 is JAM3 junctional adhesion molecule 3 on 11q25: "Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants."

1. NP_001192258.1 junctional adhesion molecule C isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1." Conserved Domains (1) summary: pfam13927 Location: 83 → 172 Ig_3; Immunoglobulin domain.
2. NP_116190.3 junctional adhesion molecule C isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1)." Conserved Domains (2) summary: smart00410 Location: 42 → 135 IG_like; Immunoglobulin like and pfam13927 Location: 142 → 223 Ig_3; Immunoglobulin domain.

Gene ID: 120425 is JAML junction adhesion molecule like on 11q23.3.

1. NP_001091996.1 junctional adhesion molecule-like isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longest isoform (1)." Conserved Domains (2) summary: smart00410 Location: 27 → 135 IG_like; Immunoglobulin like and pfam07686 Location: 26 → 136 V-set; Immunoglobulin V-set domain.
2. NP_001273499.1 junctional adhesion molecule-like isoform 3: "Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3)." Conserved Domains (2) summary: smart00410 Location: 158 → 212 IG_like; Immunoglobulin like and pfam07686 Location: 3 → 97 V-set; Immunoglobulin V-set domain.
3. NP_001273500.1 junctional adhesion molecule-like isoform 3: "Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3)." Conserved Domains (2) summary: smart00410 Location: 158 → 212 IG_like; Immunoglobulin like and pfam07686 Location: 3 → 97 V-set; Immunoglobulin V-set domain.
4. NP_694938.2 junctional adhesion molecule-like isoform 2: "Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1." Conserved Domains (2) summary: smart00410 Location: 187 → 241 IG_like; Immunoglobulin like and pfam07686 Location: 16 → 126 V-set; Immunoglobulin V-set domain.
5. XP_016872703.1 junctional adhesion molecule-like isoform X3 Conserved Domains (1) summary: cl11960 Location: 45 → 103 Ig; Immunoglobulin domain.
6. XP_016872704.1 junctional adhesion molecule-like isoform X3 Conserved Domains (1) summary: cl11960 Location: 45 → 103 Ig; Immunoglobulin domain.
7. XP_024304119.1 junctional adhesion molecule-like isoform X3 Conserved Domains (1) summary: cl11960 Location: 45 → 103 Ig; Immunoglobulin domain.
8. XP_005271464.1 junctional adhesion molecule-like isoform X2 Conserved Domains (2) summary: smart00410 Location: 17 → 125 IG_like; Immunoglobulin like pfam07686 Location: 16 → 126 V-set; Immunoglobulin V-set domain.

Gene ID: 340547 is VSIG1 V-set and immunoglobulin domain containing 1 on Xq22.3: "This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene."

1. NP_001164024.1 V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longer isoform (1)." Conserved Domains summary: cd00096 Location: 193 → 260 Ig; Immunoglobulin domain, smart00410 Location: 190 → 263 IG_like; Immunoglobulin like and cl11960 Location: 28 → 163 Ig; Immunoglobulin domain.
2. NP_872413.1 V-set and immunoglobulin domain-containing protein 1 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1." Conserved Domains summary: pfam13927 Location: 142 → 215 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 127 Ig; Immunoglobulin domain.
3. XP_011529238.1 V-set and immunoglobulin domain-containing protein 1 isoform X1 Conserved Domains (3) summary: cd00096 Location: 212 → 279 Ig; Immunoglobulin domain, smart00410 Location: 209 → 282 IG_like; Immunoglobulin like and cl11960 Location: 90 → 182 Ig; Immunoglobulin domain
4. XP_005262184.1 V-set and immunoglobulin domain-containing protein 1 isoform X2 Conserved Domains (3) summary: cd00096 Location: 219 → 286 Ig; Immunoglobulin domain and smart00410 Location: 216 → 289 IG_like; Immunoglobulin like and cl11960 Location: 97 → 189 Ig; Immunoglobulin domain.

Major histocompatibility complex genes

Main article: Major histocompatibility complex

Class I

Main article: MHC class I

Main article: Major histocompatibility complex class I gene family

Class II

Main article: MHC class II

Main article: Major histocompatibility complex class II gene family

Class III

Main article: Major histocompatibility complex class III gene family

See also

• Alpha-1-B glycoprotein
• Complex locus A1BG and ZNF497
• Immunoglobulin supergene family
• SCAN domain

External links

• GenomeNet KEGG database
• Home - Gene - NCBI
• NCBI All Databases Search
• NCBI Site Search

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