Brain-specific angiogenesis inhibitor 2: Difference between revisions

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{{Redirect|BAI2|the banking file format|BAI (file format)}}
{{Infobox_gene}}
'''Brain-specific angiogenesis inhibitor 2''' is a [[protein]] that in humans is encoded by the ''BAI2'' [[gene]].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenet Cell Genet | volume = 79 | issue = 1-2 | pages = 103–8 |date=Apr 1998 | pmid = 9533023 | pmc =  | doi =10.1159/000134693  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=576| accessdate = }}</ref> It is a member of the [[adhesion-GPCRs|adhesion-GPCR]] family of receptors.<ref>{{cite book|last=Stacey|first=edited by Simon Yona, Martin|title=Adhesion-GPCRs : structure to function|year=2010|publisher=Springer Science+Business Media|location=New York|isbn=9781441979124}}</ref>


[[BAI1]], a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez"/>


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==References==
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| image = 
| image_source = 
| PDB =
| Name = Brain-specific angiogenesis inhibitor 2
| HGNCid = 944
| Symbol = BAI2
| AltSymbols =;
| OMIM = 602683
| ECnumber = 
| Homologene = 1288
| MGIid = 2451244
| GeneAtlas_image1 = PBB_GE_BAI2_204966_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0016527 |text = brain-specific angiogenesis inhibitor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 576
    | Hs_Ensembl = ENSG00000121753
    | Hs_RefseqProtein = NP_001694
    | Hs_RefseqmRNA = NM_001703
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 31965305
    | Hs_GenLoc_end = 32002223
    | Hs_Uniprot = O60241
    | Mm_EntrezGene = 230775
    | Mm_Ensembl = ENSMUSG00000028782
    | Mm_RefseqmRNA = NM_173071
    | Mm_RefseqProtein = NP_775094
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 129494372
    | Mm_GenLoc_end = 129524652
    | Mm_Uniprot = Q80T36
  }}
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'''Brain-specific angiogenesis inhibitor 2''', also known as '''BAI2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=576| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==External links==
{{PBB_Summary
* {{UCSC gene info|ADGRB2}}
| section_title =  
| summary_text = BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=576| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
 
{{PBB_Further_reading
*{{cite journal  | vauthors=Kreienkamp HJ, Zitzer H, Gundelfinger ED |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387–90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Kee HJ, Koh JT, Kim MY |title=Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. |journal=J. Cereb. Blood Flow Metab. |volume=22 |issue= 9 |pages= 1054–67 |year= 2002 |pmid= 12218411 |doi= 10.1097/00004647-200209000-00003 |display-authors=etal}}
*{{cite journal  | author=Shiratsuchi T, Nishimori H, Ichise H, ''et al.'' |title=Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 103-8 |year= 1998 |pmid= 9533023 |doi=  }}
*{{cite journal  | vauthors=Petersen HH, Hilpert J, Militz D |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. |journal=J. Cell Sci. |volume=116 |issue= Pt 3 |pages= 453–61 |year= 2003 |pmid= 12508107 |doi=10.1242/jcs.00243 |display-authors=etal}}
*{{cite journal  | author=Kreienkamp HJ, Zitzer H, Gundelfinger ED, ''et al.'' |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387-90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200 }}
*{{cite journal  | vauthors=Adkins JN, Varnum SM, Auberry KJ |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell. Proteomics |volume=1 |issue= 12 |pages= 947–55 |year= 2003 |pmid= 12543931 |doi=  10.1074/mcp.M200066-MCP200|display-authors=etal}}
*{{cite journal  | author=Kee HJ, Koh JT, Kim MY, ''et al.'' |title=Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. |journal=J. Cereb. Blood Flow Metab. |volume=22 |issue= 9 |pages= 1054-67 |year= 2002 |pmid= 12218411 |doi= 10.1097/00004647-200209000-00003 }}
*{{cite journal  | vauthors=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654–65 |year= 2004 |pmid= 14697242 |doi=10.1016/j.bbrc.2003.12.001 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Petersen HH, Hilpert J, Militz D, ''et al.'' |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. |journal=J. Cell. Sci. |volume=116 |issue= Pt 3 |pages= 453-61 |year= 2003 |pmid= 12508107 |doi=  }}
*{{cite journal  | vauthors=Bjarnadóttir TK, Fredriksson R, Höglund PJ |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |display-authors=etal}}
*{{cite journal  | author=Adkins JN, Varnum SM, Auberry KJ, ''et al.'' |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947-55 |year= 2003 |pmid= 12543931 |doi=  }}
 
*{{cite journal  | author=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654-65 |year= 2004 |pmid= 14697242 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]


{{WH}}
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{{WS}}
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[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]

References

  1. ↑ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
  2. ↑ 2.0 2.1 "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
  3. ↑ Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124.

External links

Further reading

  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
  • Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi:10.1097/00004647-200209000-00003. PMID 12218411.
  • Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
  • Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
  • Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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