TEA consensus sequence gene transcriptions

Jump to navigation Jump to search

Associate Editor(s)-in-Chief: Henry A. Hoff

"The TEA/ATTS transcription factor family consists of mammalian, avian, nematode, insect and fungal members that share a conserved TEA domain. The TEA domain (Bürglin, 1991) represents a DNA‐binding region that is composed of 66–76 conserved amino acids (aa) in the N‐terminal section of the proteins."[1]

Human genes

Gene expressions

Interactions

Consensus sequences

"The TEA consensus sequence (TCS) in a fungal TEA/ATTS transcription factor target promoter has been defined as 5′‐CATTCY‐3′ (Andrianopoulos and Timberlake, 1994)."[1]

Binding site for

Enhancer activity

Promoter occurrences

Hypotheses

  1. A1BG has no regulatory elements in either promoter.
  2. A1BG is not transcribed by a regulatory element.
  3. No regulatory element participates in the transcription of A1BG.

TEA samplings

Copying a responsive elements consensus sequence CATTC(C/T) and putting the sequence in "⌘F" finds three between ZNF497 and A1BG or 2 between ZSCAN22 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence CATTC(C/T) (starting with SuccessablesTEA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

  1. negative strand, negative direction, looking for CATTC(C/T), 2, CATTCT at 3893, CATTCT at 2503.
  2. positive strand, negative direction, looking for CATTC(C/T), 0.
  3. positive strand, positive direction, looking for CATTC(C/T), 1, CATTCC at 2457.
  4. negative strand, positive direction, looking for CATTC(C/T), 2, CATTCT at 3074, CATTCC at 2208.
  1. inverse complement, negative strand, negative direction, looking for (A/G)GAATG, 0.
  2. inverse complement, positive strand, negative direction, looking for (A/G)GAATG, 3, GGAATG at 4554, AGAATG at 3003, AGAATG at 1947.
  3. inverse complement, positive strand, positive direction, looking for (A/G)GAATG, 2, AGAATG at 1887, AGAATG at 523.
  4. inverse complement, negative strand, positive direction, looking for (A/G)GAATG, 8, AGAATG at 3834, GGAATG at 3566, GGAATG at 3440, GGAATG at 3366, AGAATG at 3068, AGAATG at 2840, AGAATG at 1419, AGAATG at 1319.

TEA UTRs

Negative strand, negative direction: CATTCT at 3893.

Positive strand, negative direction: GGAATG at 4554, AGAATG at 3003.

TEA core promoters

TEA proximal promoters

TEA distal promoters

Negative strand, negative direction: CATTCT at 2503.

Positive strand, negative direction: AGAATG at 1947.

Negative strand, positive direction: AGAATG at 3834, GGAATG at 3566, GGAATG at 3440, GGAATG at 3366, CATTCT at 3074, AGAATG at 3068, AGAATG at 2840, CATTCC at 2208, AGAATG at 1419, AGAATG at 1319.

Positive strand, positive direction: CATTCC at 2457, AGAATG at 1887, AGAATG at 523.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

See also

References

  1. 1.0 1.1 Anja Schweizer, Steffen Rupp, Brad N. Taylor, Martin Röllinghoff, Klaus Schröppel (November 2000). "The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans". Molecular Microbiology. 38 (3): 435–445. doi:10.1046/j.1365-2958.2000.02132.x. Retrieved 21 April 2021.

External links