MYB recognition element gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

A rosette of Arabidopsis thaliana with the inflourescence just emerging at the centre is imaged. Credit: Quentin Groom.{{free media}}

"Another class of cis-acting elements is represented by Boxes P and L from the parsley phenylalanine ammonia-lyase (PAL) and 4-coumarate:CoA ligase (4CL) genes and the H-box from the bean chalcone synthase gene Chs15 [23,24]."^[1]

"The combination of an [ACGT-containing element] ACE and a MRE confers light responsiveness to the CFI, F3H and FLS promoters."^[2]

Human genes

Gene ID: 4602 is MYB [myeloblastosis] MYB proto-oncogene, transcription factor on 6q23.3: "This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants."^[3]

Gene expressions

"Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols."^[2]

In "Arabidopsis thaliana all four corresponding genes are coordinately expressed in response to light, and are spatially coexpressed in siliques, flowers and leaves."^[2]

"Light regulatory units (LRUs) sufficient for light responsiveness were identified in all four promoters."^[2]

A "R response element (RRE) was identified in the CHS promoter."^[2]

"Only the ACE from the CFI promoter shows flanking sequences giving rise to a symmetrical G-box (Foster et al., 1994; Menkens et al., 1995) that also fits the consensus of the R motif (CANNTG; Blackwell and Weintraub, 1990; Bodeau and Walbot, 1996) which is recognized by [basic helix-loop-helix] BHLH factors."^[2]

The gain-of-function for the FLS gene (MRE, ACE) lies between -97 and -42.^[2]

For the F3H gene the ACE lies between -463 and -382 and the MRE lies between -99 and -63.^[2]

For the CFI gene the ACE, MRE lie between -99 and -39.^[2]

For the CHS gene the ACE, RRE, MRE lie between -106 and -69.^[2]

Consensus sequences

"These elements fit the type II MYB consensus sequence A(A/C)C(A/T)A(A/C)C, suggesting that they are MYB recognition elements (MREs)."^[1]

The consensus sequence for the RRE is 5'-CATCTG-3'.^[2]

The consensus sequence for the ACE is 5'-CACGT-3'.^[2]

Hypotheses

A1BG has no MYB recognition elements (MRE) in either promoter.
A1BG is not transcribed by a MRE.
No MRE participates in the transcription of A1BG.

MRE samplings

Copying an apparent core consensus sequence for the MYBRE of AACAAAC or TAACTG and putting it in "⌘F" finds none located between ZSCAN22 and none or one between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence A(A/C)C(A/T)A(A/C)C (starting with SuccessablesMYB.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for A(A/C)C(A/T)A(A/C)C, 2, ACCAACC at 3946, ACCAACC at 3606.
positive strand, negative direction, looking for A(A/C)C(A/T)A(A/C)C, 5, AACAACC at 2844, AACAAAC at 2511, AACAAAC at 2486, AACAAAC at 1587, AACAAAC at 1390.
positive strand, positive direction, looking for A(A/C)C(A/T)A(A/C)C, 0.
negative strand, positive direction, looking for A(A/C)C(A/T)A(A/C)C, 1, ACCAAAC at 3176.
complement, negative strand, negative direction, looking for T(G/T)G(A/T)T(G/T)G, 5, TTGTTGG at 2844, TTGTTTG at 2511, TTGTTTG at 2486, TTGTTTG at 1587, TTGTTTG at 1390.
complement, positive strand, negative direction, looking for T(G/T)G(A/T)T(G/T)G, 2, TGGTTGG at 3946, TGGTTGG at 3606.
complement, positive strand, positive direction, looking for T(G/T)G(A/T)T(G/T)G, 1, TGGTTTG at 3176.
complement, negative strand, positive direction, looking for T(G/T)G(A/T)T(G/T)G, 0.
inverse complement, negative strand, negative direction, looking for G(G/T)T(A/T)G(G/T)T, 5, GGTAGGT at 4457, GGTTGTT at 3139, GTTTGTT at 2488, GTTTGTT at 2484, GTTTGTT at 1392.
inverse complement, positive strand, negative direction, looking for G(G/T)T(A/T)G(G/T)T, 0.
inverse complement, positive strand, positive direction, looking for G(G/T)T(A/T)G(G/T)T, 1, GGTAGGT at 3109.
inverse complement, negative strand, positive direction, looking for G(G/T)T(A/T)G(G/T)T, 0.
inverse negative strand, negative direction, looking for C(A/C)A(A/T)C(A/C)A, 0.
inverse positive strand, negative direction, looking for C(A/C)A(A/T)C(A/C)A, 5, CCATCCA at 4457, CCAACAA at 3139, CAAACAA at 2488, CAAACAA at 2484, CAAACAA at 1392.
inverse positive strand, positive direction, looking for C(A/C)A(A/T)C(A/C)A, 0.
inverse negative strand, positive direction, looking for C(A/C)A(A/T)C(A/C)A, 1, CCATCCA at 3109.

MRE UTR gene transcriptions

Negative strand, negative direction: GGTAGGT at 4457, ACCAACC at 3946, ACCAACC at 3606, GGTTGTT at 3139.

MRE core promoters

Positive strand, negative direction: AACAACC at 2844.

MRE distal promoters

Negative strand, negative direction: GTTTGTT at 2488, GTTTGTT at 2484, GTTTGTT at 1392.

Positive strand, negative direction: AACAAAC at 2511, AACAAAC at 2486, AACAAAC at 1587, AACAAAC at 1390.

Positive strand, positive direction: GGTAGGT at 3109.

Negative strand, positive direction: ACCAAAC at 3176.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

Initial content for this page in some instances came from Wikiversity.

Initial content for this page in some instances incorporates text from the United States National Library of Medicine.

References

↑ ^1.0 ^1.1 Paul J Rushton and Imre E Somssich (August 1998). "Transcriptional control of plant genes responsive to pathogens" (PDF). Current Opinion in Plant Biology. 1 (4): 311–5. doi:10.1016/1369-5266(88)80052-9. Retrieved 5 November 2018.
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Ulrike Hartmann, Martin Sagasser, Frank Mehrtens, Ralf Stracke and Bernd Weisshaar (January 2005). "Differential combinatorial interactions of cis-acting elements recognized by R2R3-MYB, BZIP, and BHLH factors control light-responsive and tissue-specific activation of phenylpropanoid biosynthesis genes" (PDF). Plant Molecular Biology. 57 (2): 155–171. doi:10.1007/s11103-004-6910-0. Retrieved 10 November 2018.
↑ RefSeq (January 2016). "MYB MYB proto-oncogene, transcription factor [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 7 February 2021.

External links

[Rushton-1] 1.0 ^1.1 Paul J Rushton and Imre E Somssich (August 1998). "Transcriptional control of plant genes responsive to pathogens" (PDF). Current Opinion in Plant Biology. 1 (4): 311–5. doi:10.1016/1369-5266(88)80052-9. Retrieved 5 November 2018.

[Hartmann-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Ulrike Hartmann, Martin Sagasser, Frank Mehrtens, Ralf Stracke and Bernd Weisshaar (January 2005). "Differential combinatorial interactions of cis-acting elements recognized by R2R3-MYB, BZIP, and BHLH factors control light-responsive and tissue-specific activation of phenylpropanoid biosynthesis genes" (PDF). Plant Molecular Biology. 57 (2): 155–171. doi:10.1007/s11103-004-6910-0. Retrieved 10 November 2018.

[RefSeq4602-3] RefSeq (January 2016). "MYB MYB proto-oncogene, transcription factor [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 7 February 2021.

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[2]

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transcriptions MYB recognition element gene transcriptions Myelocytomatosis transcription factor gene transcriptions Myocyte enhancer factor gene transcriptions N-boxes Ndt80p gene transcriptions Nuclear factor 1 Nuclear factor 𝜿B Nuclear factor gene transcriptions Nuclear factor of activated T cell gene transcriptions (NFAT) Nuclear factor Y gene transcriptions Nutrient-sensing response element gene transcriptions Oaf1p gene transcriptions ORE1 binding site gene transcriptions p53 response element gene transcriptions P63 DNA-binding site gene transcriptions P box gene transcriptions Pdr1,3p gene transcriptions Peroxisome proliferator hormone response element gene transcriptions Phosphate starvation-response transcription factor gene transcriptions Pollen1 element gene transcriptions Polycomb response element gene transcriptions Preinitiation complex Preinitiation complex gene transcriptions Pribnow box gene transcriptions Prolamin box gene transcriptions Promoter gene transcriptions Proximal promoter gene transcriptions Promoter occurrence gene transcriptions Pyrimidine box gene transcriptions Q element gene transcriptions Rap1 regulatory factor gene transcriptions Reb1 general regulatory factor gene transcriptions Retinoblastoma control element gene transcriptions Retinoic acid response element gene transcriptions Rgt1p gene transcriptions Rlm1p gene transcriptions RNA polymerase II gene transcriptions RNA polymerase II holoenzyme complex Root specific element gene transcriptions ROR-response element gene transcriptions Rox1p gene transcriptions Rpn4p gene transcriptions R response element gene transcriptions SARE gene transcriptions Seed-specific element gene transcriptions Serum response element gene transcriptions Servenius sequence gene transcriptions Shoot specific element gene transcriptions Sip4p gene transcriptions Smp1p gene transcriptions Sp1 gene transcriptions Spaceflight gene expressions Specificity protein gene transcriptions STAT gene transcriptions Ste12p gene transcriptions Sterol response element gene transcriptions Sucrose box gene transcriptions Synaptic Activity-Responsive Elements TACTAAC box gene transcriptions TAGteam gene transcriptions Tapetum box gene transcriptions TATA binding protein associated factor gene transcriptions TATA binding protein gene transcriptions TATA box gene transcriptions TAT box gene transcriptions TATC box gene transcriptions Tbf1 regulatory factor gene transcriptions T box gene transcriptions TCCACCATA element gene transcriptions TC element gene transcriptions TCT gene transcriptions TEA consensus sequence gene transcriptions Tec1p gene transcriptions Telomeric repeat DNA-binding factor gene transcriptions Tetradecanoylphorbol-13-acetate response element gene transcriptions TGF-β control elements (TCEs) TGF-β inhibitory elements (TIEs) Thyroid hormone response element gene transcriptions Transcriptional regulation Transcription bubble gene transcriptions Transcription factor gene transcriptions Transcription factor 3 gene transcriptions Transcription factory gene transcriptions Transcription start site gene transcriptions Translational control sequence gene transcriptions U box gene transcriptions Unfolded protein response element gene transcriptions Upstream response element gene transcriptions Upstream stimulatory factor gene transcriptions UTR promoter gene transcriptions V and P box gene transcriptions V box gene transcriptions Vhr1p gene transcriptions Vitamin D response element gene transcriptions W box gene transcriptions X box gene transcriptions Xbp1p gene transcriptions X core promoter element gene transcriptions Xenobiotic response element gene transcriptions Xenobiotic responsive element gene transcriptions Yap1p,2p gene transcriptions Y box gene transcriptions YY1 gene transcriptions Zap1p gene transcriptions Z box gene transcriptions Zinc responsive element gene transcriptions