Peroxisome proliferator hormone response element gene transcriptions: Difference between revisions

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==Consensus sequences==
==Consensus sequences==
"After activation by ligands, PPARs/RXRs heterodimers bind to PPRE consensus sequence (AGGTCANAGGTCA) in the promoter of their target genes."<ref name=You>{{ cite journal
|author=Mengli You, Shuping Yuan, Juanjuan Shi, Yongzhong Hou
|title=PPARδ signaling regulates colorectal cancer
|journal=Current Pharmaceutical Design
|date=1 June 2015
|volume=21
|issue=21
|pages=2956-2959
|url=https://www.ingentaconnect.com/content/ben/cpd/2015/00000021/00000021/art00006#expand/collapse
|arxiv=
|bibcode=
|doi=10.2174/1381612821666150514104035
|pmid=26004416
|accessdate=10 September 2020 }}</ref>


The DNA consensus sequence is AGGTCANAGGTCA, with N being any nucleotide.
The DNA consensus sequence is AGGTCANAGGTCA, with N being any nucleotide.

Revision as of 04:46, 11 September 2020

Associate Editor(s)-in-Chief: Henry A. Hoff

Peroxisome proliferator hormone response elements (PPREs) consensus sequences are AGGGGA and TCCCCT.[1]

Human genes

Consensus sequences

"After activation by ligands, PPARs/RXRs heterodimers bind to PPRE consensus sequence (AGGTCANAGGTCA) in the promoter of their target genes."[2]

The DNA consensus sequence is AGGTCANAGGTCA, with N being any nucleotide.

Samplings

Copying the apparent consensus sequence for the PPRE (AGGGGA) and putting it in "⌘F" finds none located between ZSCAN22 or three between ZNF497 and A1BG as can be found by the computer programs.

See also

References

  1. Yao EF, Denison MS (June 1992). "DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer". Biochemistry. 31 (21): 5060–7. doi:10.1021/bi00136a019. PMID 1318077.
  2. Mengli You, Shuping Yuan, Juanjuan Shi, Yongzhong Hou (1 June 2015). "PPARδ signaling regulates colorectal cancer". Current Pharmaceutical Design. 21 (21): 2956–2959. doi:10.2174/1381612821666150514104035. PMID 26004416. Retrieved 10 September 2020.

External links