GPR75: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 75''' is a [[protein]] that in humans is encoded by the ''GPR75'' [[gene]].<ref name="pmid10381362">{{cite journal | vauthors = Tarttelin EE, Kirschner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K, Csaky K, Stratakis CA, Gregory-Evans CY | title = Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16 | journal = Biochemical and Biophysical Research Communications | volume = 260 | issue = 1 | pages = 174–80 | date = June 1999 | pmid = 10381362 | pmc =  | doi = 10.1006/bbrc.1999.0753 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR75 G protein-coupled receptor 75 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10936}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 75
| HGNCid = 4526
| Symbol = GPR75
| AltSymbols =; GPR-chr2; WI-31133
| OMIM = 606704
| ECnumber = 
| Homologene = 4945
| MGIid = 2441843
| GeneAtlas_image1 = PBB_GE_GPR75_220481_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10936
    | Hs_Ensembl = ENSG00000119737
    | Hs_RefseqProtein = NP_006785
    | Hs_RefseqmRNA = NM_006794
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 53933775
    | Hs_GenLoc_end = 53935397
    | Hs_Uniprot = O95800
    | Mm_EntrezGene = 237716
    | Mm_Ensembl = ENSMUSG00000043999
    | Mm_RefseqmRNA = NM_175490
    | Mm_RefseqProtein = NP_780699
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 30791097
    | Mm_GenLoc_end = 30792719
    | Mm_Uniprot = Q059L0
  }}
}}
'''G protein-coupled receptor 75''', also known as '''GPR75''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR75 G protein-coupled receptor 75| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10936| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GPR75 is a member of the [[G protein-coupled receptor]] family. GPRs are cell surface receptors that activate [[guanine-nucleotide binding protein]]s upon the binding of a ligand.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR75 G protein-coupled receptor 75| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10936| accessdate = }}</ref>
}}


==References==
GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine [[CCL5]] (RANTES) has been shown to stimulate calcium mobilization and [[inositol triphosphate]] formation in GPR75-transfected cells.<ref>{{cite journal | vauthors = Ignatov A, Robert J, Gregory-Evans C, Schaller HC | title = RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 | journal = British Journal of Pharmacology | volume = 149 | issue = 5 | pages = 490–7 | date = November 2006 | pmid = 17001303 | pmc = 2014681 | doi = 10.1038/sj.bjp.0706909 }}</ref>
{{reflist|2}}
 
==Further reading==
Recently, [[20-hydroxyeicosatetraenoic acid]] (20-HETE), a bioactive eicosanoid formed by ω-hydroxylation of [[arachidonic acid]] has been shown to mediate its prohypertensive effects on the vasculature through activation of GPR75 (Gq) signalling.<ref>{{cite journal | vauthors = Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML | title = 20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension | journal = Circulation Research | volume = 120 | issue = 11 | pages = 1776–1788 | date = May 2017 | pmid = 28325781 | pmc = 5446268 | doi = 10.1161/CIRCRESAHA.116.310525 }}</ref> This study by Dr. Schwartzman's laboratory at New York Medical college, one of the pioneers in study of 20-HETE biology, has opened new insights into the field of GPR75 pharmacology.
{{refbegin | 2}}
 
{{PBB_Further_reading
== References ==
| citations =
{{reflist}}
*{{cite journal | author=Tarttelin EE, Kirschner LS, Bellingham J, ''et al.'' |title=Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 174-80 |year= 1999 |pmid= 10381362 |doi= 10.1006/bbrc.1999.0753 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
{{transmembranereceptor-stub}}

Revision as of 00:58, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene.[1][2]

Function

GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[2]

GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine CCL5 (RANTES) has been shown to stimulate calcium mobilization and inositol triphosphate formation in GPR75-transfected cells.[3]

Recently, 20-hydroxyeicosatetraenoic acid (20-HETE), a bioactive eicosanoid formed by ω-hydroxylation of arachidonic acid has been shown to mediate its prohypertensive effects on the vasculature through activation of GPR75 (Gq) signalling.[4] This study by Dr. Schwartzman's laboratory at New York Medical college, one of the pioneers in study of 20-HETE biology, has opened new insights into the field of GPR75 pharmacology.

References

  1. ↑ Tarttelin EE, Kirschner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K, Csaky K, Stratakis CA, Gregory-Evans CY (June 1999). "Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16". Biochemical and Biophysical Research Communications. 260 (1): 174–80. doi:10.1006/bbrc.1999.0753. PMID 10381362.
  2. ↑ 2.0 2.1 "Entrez Gene: GPR75 G protein-coupled receptor 75".
  3. ↑ Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006). "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75". British Journal of Pharmacology. 149 (5): 490–7. doi:10.1038/sj.bjp.0706909. PMC 2014681. PMID 17001303.
  4. ↑ Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML (May 2017). "20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension". Circulation Research. 120 (11): 1776–1788. doi:10.1161/CIRCRESAHA.116.310525. PMC 5446268. PMID 28325781.
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