Polycomb response element gene transcriptions: Difference between revisions

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"Recruitment of ''Drosophila melanogaster'' [Polycomb-group] PcG proteins to target genes requires the presence of one or more Polycomb Response Elements (PREs)."<ref name=Ghotbi/>
"Recruitment of ''Drosophila melanogaster'' [Polycomb-group] PcG proteins to target genes requires the presence of one or more Polycomb Response Elements (PREs)."<ref name=Ghotbi/>
Only "Pleiohomeotic (Pho) is present at all strong PREs."<ref name=Ghotbi/>
"The giant (gt) locus has two PREs, a proximal PRE1 and a distal PRE2. During early embryonic development, Pho binds to PRE1 ∼30-min prior to stable binding to PRE2."<ref name=Ghotbi/>
"PRE2 recruits PcG proteins and maintains transcriptional repression independently of Pho binding to PRE1. Pho-like (Phol) is partially redundant with Pho during larval development and binds to the same DNA sequences in vitro Although binding of Pho to PRE1 is dependent on the presence of consensus Pho-Phol-binding sites".<ref name=Ghotbi/>


==Human genes==
==Human genes==

Revision as of 00:43, 11 September 2020

Associate Editor(s)-in-Chief: Henry A. Hoff

"Recruitment of Drosophila melanogaster [Polycomb-group] PcG proteins to target genes requires the presence of one or more Polycomb Response Elements (PREs)."[1]

Only "Pleiohomeotic (Pho) is present at all strong PREs."[1]

"The giant (gt) locus has two PREs, a proximal PRE1 and a distal PRE2. During early embryonic development, Pho binds to PRE1 ∼30-min prior to stable binding to PRE2."[1]

"PRE2 recruits PcG proteins and maintains transcriptional repression independently of Pho binding to PRE1. Pho-like (Phol) is partially redundant with Pho during larval development and binds to the same DNA sequences in vitro Although binding of Pho to PRE1 is dependent on the presence of consensus Pho-Phol-binding sites".[1]

Human genes

Consensus sequences

"Two predicted [Pleiohomeotic] Pho-Phol binding sites, 3'-CGCCATTT-5', that closely resemble the extended Pho-Phol consensus sequence, CGCCAT(T/A)TT (Kahn et al. 2014), are located within PRE1.1 [...]."[1]

Samplings

Copying the apparent consensus sequence for the PRE (CGCCATTT) and putting it in "⌘F" finds none located between ZSCAN22 or between ZNF497 and A1BG as can be found by the computer programs.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 Elnaz Ghotbi, Kristina Lackey, Vicki Wong, Katie T. Thompson, Evan G. Caston, Minna Haddadi, Judith Benes and Richard S. Jones (1 March 2020). "Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene" (PDF). Genetics. 214 (3): 623–634. doi:10.1534/genetics.119.302981. PMID 31919108. Retrieved 7 September 2020.

External links