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Dopamine receptor D1
Identifiers
Symbols DRD1 ; DADR; DRD1A
External IDs Template:OMIM5 Template:MGI HomoloGene: 30992
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a


Overview

Dopamine receptor D1, also known as DRD1, is a human gene.

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.[1]

Ligands

File:D1 agonists.png
Chemical structures of selective D1 receptor agonists.[2][3]

See also

References

  1. ↑ "Entrez Gene: DRD1 dopamine receptor D1".
  2. ↑ 2.0 2.1 Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE (2006). "trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist". J. Med. Chem. 49 (23): 6848–57. doi:10.1021/jm0604979. PMID 17154515.
  3. ↑ 3.0 3.1 Michaelides MR, Hong Y, DiDomenico S, Asin KE, Britton DR, Lin CW, Williams M, Shiosaki K (1995). "(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431)". J. Med. Chem. 38 (18): 3445–7. doi:10.1021/jm00018a002. PMID 7658429.
  4. ↑ Yamashita M, Yamada K, Tomioka K (2004). "Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929". J. Am. Chem. Soc. 126 (7): 1954–5. doi:10.1021/ja031760n. PMID 14971926.

Further reading

  • Missale C, Nash SR, Robinson SW; et al. (1998). "Dopamine receptors: from structure to function". Physiol. Rev. 78 (1): 189–225. PMID 9457173.
  • Milligan G, White JH (2001). "Protein-protein interactions at G-protein-coupled receptors". Trends Pharmacol. Sci. 22 (10): 513–8. PMID 11583808.
  • Bermak JC, Zhou QY (2004). "Accessory proteins in the biogenesis of G protein-coupled receptors". Mol. Interv. 1 (5): 282–7. PMID 14993367.
  • Minowa MT, Minowa T, Monsma FJ; et al. (1992). "Characterization of the 5' flanking region of the human D1A dopamine receptor gene". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 3045–9. PMID 1557411.
  • Tiberi M, Jarvie KR, Silvia C; et al. (1991). "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491–5. PMID 1831904.
  • Sunahara RK, Niznik HB, Weiner DM; et al. (1990). "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5". Nature. 347 (6288): 80–3. doi:10.1038/347080a0. PMID 1975640.
  • Grandy DK, Zhou QY, Allen L; et al. (1990). "A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP". Am. J. Hum. Genet. 47 (5): 828–34. PMID 1977312.
  • Dearry A, Gingrich JA, Falardeau P; et al. (1990). "Molecular cloning and expression of the gene for a human D1 dopamine receptor". Nature. 347 (6288): 72–6. doi:10.1038/347072a0. PMID 2144334.
  • Zhou QY, Grandy DK, Thambi L; et al. (1990). "Cloning and expression of human and rat D1 dopamine receptors". Nature. 347 (6288): 76–80. doi:10.1038/347076a0. PMID 2168520.
  • Frail DE, Manelli AM, Witte DG; et al. (1994). "Cloning and characterization of a truncated dopamine D1 receptor from goldfish retina: stimulation of cyclic AMP production and calcium mobilization". Mol. Pharmacol. 44 (6): 1113–8. PMID 8264547.
  • Ohara K, Ulpian C, Seeman P; et al. (1993). "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms". Neuropsychopharmacology. 8 (2): 131–5. PMID 8471124.
  • Albrecht FE, Drago J, Felder RA; et al. (1996). "Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension". J. Clin. Invest. 97 (10): 2283–8. PMID 8636408.
  • Lee SH, Minowa MT, Mouradian MM (1996). "Two distinct promoters drive transcription of the human D1A dopamine receptor gene". J. Biol. Chem. 271 (41): 25292–9. PMID 8810292.
  • Mayerhofer A, Hemmings HC, Snyder GL; et al. (1999). "Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro". J. Clin. Endocrinol. Metab. 84 (1): 257–64. PMID 9920093.
  • Wong AC, Shetreat ME, Clarke JO, Rayport S (1999). "D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro". Neuroscience. 89 (1): 221–33. PMID 10051231.
  • Jin H, Xie Z, George SR, O'Dowd BF (2000). "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor". Eur. J. Pharmacol. 386 (2–3): 305–12. PMID 10618483.
  • Li M, Bermak JC, Wang ZW, Zhou QY (2000). "Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)". Mol. Pharmacol. 57 (3): 446–52. PMID 10692483.
  • Lezcano N, Mrzljak L, Eubanks S; et al. (2000). "Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein". Science. 287 (5458): 1660–4. PMID 10698743.
  • Ginés S, Hillion J, Torvinen M; et al. (2000). "Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8606–11. doi:10.1073/pnas.150241097. PMID 10890919.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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