L-759,656

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L-759,656
240px
Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC26H40O2
Molar mass384.593 g/mol
3D model (JSmol)

L-759,656 is an analgesic drug which is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1,[1] although it is still not as selective as newer agents such as HU-308.

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.[2][3]

References

  1. Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. British Journal of Pharmacology. 1999 Feb;126(3):665-72. PMID 10188977
  2. Huffman JW. The search for selective ligands for the CB2 receptor. Current Pharmaceutical Design. 2000 Sep;6(13):1323-37. PMID 10903395
  3. Huffman JW. CB2 receptor ligands. Mini Reviews in Medicinal Chemistry. 2005 Jul;5(7):641-9. PMID 16026310

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