JWH-081

JWH-081
	File:JWH-081.svg
Gene therapy
Clinical data
Physiological data
Legal status
Legal status	In general: legal;
Pharmacokinetic data
Identifiers
	IUPAC name 4-methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone;
PubChem Template:Abbreviation	10547208;
Chemical and physical data
Formula	C25H25NO2
Molar mass	371.47 g/mol

JWH-081 is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors.^[1] It is fairly selective for the CB₁ subtype, with affinity at this subtype approximately 10x the affinity at CB₂.^[2]

Template:Pharma-stub

References

↑ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug and Alcohol Dependance 2000; 60:133-140.
↑ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB₁ and CB₂ receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB₂ receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.

Template:WikiDoc Sources

[1] Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug and Alcohol Dependance 2000; 60:133-140.

[2] Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB₁ and CB₂ receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB₂ receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.

[1]

[2]

JWH-081

References

Navigation menu

Search