11-Hydroxy-THC

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11-Hydroxy-THC
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Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC21H30O3
Molar mass330.461 g/mol

11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) is the main active metabolite of THC which is formed in the body after cannabis is smoked[1]. 11-hydroxy-THC has been shown to be active in its own right[2], but the effects produced are not necessarily identical to those of THC[3]; it is plausible that the biphasic action of cannabis might be explained by the action of the active metabolite of THC rather than by other compounds present in the plant such as cannabidiol, so that 11-hydroxy-THC might be responsible for causing certain effects such as sleepiness and increased appetite which are characteristically delayed and occur as the initial "high" is wearing off.

11-hydroxy-THC is subsequently metabolised further to 11-carboxy-THC, which is not psychoactive but may still play a role in the analgesic and anti-inflammatory effects of cannabis.

References

  1. ^ Johnson, J.R. (September–October 1984). "Stability of delta 9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in blood and plasma". Journal of Analytical Toxicology. 8 (5): 202–204. Unknown parameter |coauthors= ignored (help)
  2. ^ Turkanis, S.A. (July 1988). "Changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids". Neuropharmacology. 27 (7): 737–742. Unknown parameter |coauthors= ignored (help)
  3. ^ Hollister, L.E. (December 1975). "Action of delta-9-tetrahydrocannabinol. An approach to the active metabolite hypothesis". Clinical Pharmacology and Therapeutics. 18 (6): 714–719. Unknown parameter |coauthors= ignored (help)




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