AM-855

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AM-855
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Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC26H38O2
Molar mass382.577 g/mol
3D model (JSmol)

AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.[1]


References

  1. Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A. Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. Bioorganic and Medicinal Chemistry Letters. 1999 Aug 2;9(15):2119-24. PMID 10465529

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