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Legal status
Legal status
  • In general: legal
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass384.469 g/mol
3D model (JSmol)

JWH-200 is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[1] but interestingly its analgesic potency in vivo was higher than that of other analogues which had stronger CB1 binding affinity in vitro,[2] around 3x that of THC but with less sedative effect,[3] most likely reflecting favourable pharmacokinetic characteristics.



  1. Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. Bell MR, D'Ambra TE, Kumar V, et al (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
  3. Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057

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