Glucose-6-phosphate isomerase

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Glucose phosphate isomerase
Image:Glucose-6-phosphate isomerase 1GZV wpmp.png Enzyme Glucose-6-phosphate isomerase PDB Code PDB 1GZV Organism Pig Tissue Muscle Complexed molecules 5-phosphoarabinoate
Symbol(s):	GPI
Genetic data
Locus:	Chr. 19 q13.1
Database Links
EC number:	5.3.1.9
Entrez:	2821
OMIM:	172400
RefSeq:	NM_000175
UniProt:	P06744

Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. An unrelated enzyme, D-xylose isomerase (EC 5.3.1.5) catalyzes the isomerization of glucose to fructose, and is sometimes called "glucose isomerase".

The human variant of this enzyme is encoded by the GPI gene.

In glycolysis

α-D-Glucose 6-phosphate	Phosphoglucose isomerase		β-D-Fructose 6-phosphate
	Phosphoglucose isomerase

As a glucose isomerase

D-Glucose	Phosphoglucose isomerase		D-Fructose
			Image:D-fructose wpmp.png
	Phosphoglucose isomerase

Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

Template:Gluconeogenesis

v • d • e Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
Glycolysis	Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase
Gluconeogenesis only	Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase
Regulatory	Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase

v • d • e Intramolecular oxidoreductases isomerases (EC 5.3)
5.3.1 - Aldoses/Ketoses	Triosephosphate isomerase - Phosphopentose isomerase - Mannose phosphate isomerase - Glucose isomerase
5.3.3 - C=C	Isopentenyl-diphosphate delta isomerase - Enoyl CoA isomerase
5.3.4 - S-S	Protein disulfide isomerase (PDIA3)
5.3.99 - other	Prostaglandin D2 synthase - Prostaglandin E synthase - Prostacyclin synthase - Thromboxane-A synthase

Template:Metabolism-stubTemplate:Isomerase-stubfr:Glucose isomérase ja:グルコースリン酸イソメラーゼ