Enolase

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Enolase (enol + suffix -ase) or 2-phospho-D-glycerate hydrolyase is an enzyme that participates in glycolysis.

Enolase catalyzes the conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate.

Isozymes

In humans there are five distinct enolase isozymes.

• Alpha-enolase (ENO1) is ubiquitous in the cytoplasm of cells.
• Beta (ENO3 ) is associated with muscle tissue.
• Gamma (ENO2) is neuronal specific.

A type of enolase in glycolysis is phosphopyruvate hydratase.

Enolase superfamily

The enzyme is an archetypal member of an enzyme superfamily (the enolase superfamily), whereby a group of evolutionarily related enzymes share similar reaction mechanisms but function on different substrates (with altered substrate affinity) and in different biochemical context.

Inhibition

Enolase is inhibited by fluoride.

External links

• MeSH Enolase
• EC 4.2.1.11

Template:Metabolic pathway stub Template:Enzyme-stub

v • d • e  Glycolysis Metabolic Pathway

Glucose Hexokinase Glucose-6-phosphate Phosphoglucoisomerase Fructose 6-phosphate Phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde phosphate dehydrogenase ATP ADP ATP ADP NAD+ + Pi NADH + H+ + 2 NAD+ + Pi NADH + H+ 1,3-Bisphosphoglycerate Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Enolase Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2 2 2 2 2 2 2 ADP ATP H2O

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