Enolase

Jump to: navigation, search
Enolase
220px
Enzyme Enolase
PDB Code PDB: 2ONE
Organism Yeast
Complexed molecules 2-phosphoglycerate and phosphoenolpyruvate
File:Enolase.png
Enolase: 9th glycolysis enzyme. The Glycolytic Enzymes 09 -(PDB code=2one) (more details...)

Enolase (enol + suffix -ase) or 2-phospho-D-glycerate hydrolyase is an enzyme that participates in glycolysis.

Enolase catalyzes the conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate.

Isozymes

In humans there are five distinct enolase isozymes.

  • Alpha-enolase (ENO1) is ubiquitous in the cytoplasm of cells.
  • Beta (ENO3 ) is associated with muscle tissue.
  • Gamma (ENO2) is neuronal specific.

A type of enolase in glycolysis is phosphopyruvate hydratase.

Enolase superfamily

The enzyme is an archetypal member of an enzyme superfamily (the enolase superfamily), whereby a group of evolutionarily related enzymes share similar reaction mechanisms but function on different substrates (with altered substrate affinity) and in different biochemical context.

Inhibition

Enolase is inhibited by fluoride.

External links

Template:Metabolic pathway stub


Linked-in.jpg