p14arf
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| cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
| |
| Identifiers | |
| Symbol | CDKN2A |
| Alt. Symbols | CDKN2, MLM |
| Entrez | 1029 |
| HUGO | 1787 |
| OMIM | 600160 |
| RefSeq | NM_000077 |
| UniProt | P42771 |
| Other data | |
| Locus | Chr. 9 p21 |
p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the [[G1/S checkpoint]] of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in MDM2 and therefore loss of p53 function and cell cycle control.
External links
Tumor suppressor genes/proteins |
|---|
| APC - BRCA1 - BRCA2 - CHEK2 - Neurofibromin 1 - Maspin - Neurofibromin 2/Merlin - p14arf - p16 - p21 - p27 - p53 - p57 - p73 - pRb - PTEN - SDHB - SDHD - VHL |
Cell cycle proteins | |
|---|---|
| Cyclin | A - B - D - E |
| Cyclin-dependent kinase | 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase |
| Cyclin-dependent kinase inhibitor protein | p14arf/p16INK4a - p21 - p27 - p57 |
| Other | Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
