Primary amyloidosis differential diagnosis: Difference between revisions
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* Biopsy: | * Biopsy: | ||
** Diffuse glomerular deposition of amorphous hyaline material (nodular pattern), in mesangium (weakly staining with periodic acid-Schiff (PAS) | ** Diffuse glomerular deposition of amorphous hyaline material (nodular pattern - 8 to15 nm in diameter), in mesangium (weakly staining with periodic acid-Schiff (PAS) | ||
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* Melphalan-prednisone/dexamethasone | * Melphalan-prednisone/dexamethasone | ||
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* Quartan malaria | * Quartan malaria | ||
* Systemic lupus erythematosis (SLE) <br /> | * Systemic lupus erythematosis (SLE) <br /> | ||
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* Headache | * Headache | ||
* Edema affecting any area of the body | * Edema affecting any area of the body | ||
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** Glomerulosclerosis | ** Glomerulosclerosis | ||
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* Prednisone | |||
* Methylprednisolone with cyclophosphamide | |||
* Tacrolimus with a six-month taper | |||
* Rituximab | |||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Fibrillary-Immunotactoid Glomerulopathy | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Fibrillary-Immunotactoid Glomerulopathy | ||
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* Idiopathic | |||
* Hepatitis C | |||
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* Proteinuria | |||
* Hypertension | |||
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* Biopsy: | |||
** Polycloncal IgG deposits | |||
** Infiltration of glomerular structures by amorphous acellular material (nonbranching fibrils 12-24nm in diameter) | |||
** Ig heavy-chain and one light-chain subclass | |||
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Revision as of 16:41, 30 October 2019
Primary amyloidosis Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Primary amyloidosis differential diagnosis On the Web |
American Roentgen Ray Society Images of Primary amyloidosis differential diagnosis |
Risk calculators and risk factors for Primary amyloidosis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
- Differentiating Primary amyloidosis from Other Diseases
Organ System Involvement | Differential Diagnosis | Causes | Clinical Features | Laboratory Findings | Gold Standard Test | Therapy |
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Nephrotic Syndrome and Real Failure | Primary (AL) Amyloidosis |
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Diabetic Nephropathy |
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Minimal Change Disease |
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Focal Segmental Glomerulosclerosis |
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Fabry's Disease |
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Light Chain Deposition Disease | ||||||
Membranous Glomerulonephritis |
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Fibrillary-Immunotactoid Glomerulopathy |
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Organ System Involvement | Differential Diagnosis | Causes | Clinical Features | Laboratory Findings | Gold Standard Test | Therapy |
Polyneuropathy | POEMS syndrome (Demyelinating) |
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Metabolic Syndrome (Axonal pathology) |
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Vitamin Deficiencies (Axonal Pathology) |
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Guillain-Barre Syndrome (Demyelinating) |
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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (Mixed axonal and demyelinatiing) |
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Multifocal Motor Neuropathy |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Organomegaly (Hepatosplenomegaly and Lymphadenopathy) | Malaria |
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Kala-azar |
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Infective Hepatitis |
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Chronic Myelogenous Leukemia (CML) |
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Lymphoma |
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Primary (AL) Amyloidosis |
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Gaucher's Disease |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Cardiac Failure |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Plasma Cell Dyscrasias | Multiple myeloma |
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AND
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Monoclonal gammopathy of undetermined significance (MGUS) |
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AND
AND
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Asymptomatic Plasma Cell Myeloma |
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OR
AND/OR
AND
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Plasmacytoma |
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Skin Changes | Scurvy |
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