Sulfadoxine

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Sulfadoxine
Sulfadoxine Wiki Str.png
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E number{{#property:P628}}
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Chemical and physical data
FormulaC12H14N4O4S
Molar mass310.33 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria.[1] Due to high levels of resistance, its use is no longer recommended routinely.[2] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[3]

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]

Mechanism of action

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.

Synthesis

700px U.S. Patent 3,132,139 BE 618639  [5][6]

See also

References

  1. Medical Treatment - Sulphadoxine and Pyrimethamine.
  2. Matondo SI, Temba GS, Kavishe AA; et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
  3. http://en.scientificcommons.org/19483411.
  4. "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
  5. Template:Cite doi
  6. Template:Cite doi

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