Jump to navigation Jump to search

Typical "owl eye" inclusion indicating CMV infection of a lung pneumocyte[1]
Typical "owl eye" inclusion indicating CMV infection of a lung pneumocyte[1]
Virus classification
Group: Group I (dsDNA)
Order: Herpesvirales
Family: Herpesviridae
Subfamily: Betaherpesvirinae
Genus: Cytomegalovirus
Type species
Human cytomegalovirus

Cytomegalovirus infection Microchapters


Patient Information


Historical Perspective




Differentiating Cytomegalovirus infection from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cytomegalovirus On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Cytomegalovirus

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cytomegalovirus

CDC on Cytomegalovirus

Cytomegalovirus in the news

Blogs on Cytomegalovirus

Directions to Hospitals Treating Cytomegalovirus infection

Risk calculators and risk factors for Cytomegalovirus

This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Cytomegalovirus infection .

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Cytomegalovirus (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Human and monkeys serve as natural hosts. There are currently eight species in this genus including the type species human herpesvirus 5. Diseases associated with HHV-5 include mononucleosis, and pneumonias.[2][3] It is typically abbreviated as CMV.

The species that infects humans is commonly known as human CMV (HCMV) or human herpesvirus-5 (HHV-5), and is the most studied of all cytomegaloviruses.[4] Within Herpesviridae, CMV belongs to the Betaherpesvirinae subfamily, which also includes the genera Muromegalovirus and Roseolovirus (HHV-6 and HHV-7).[5] It is related to other herpesviruses within the subfamilies of Alphaherpesvirinae that includes herpes simplex viruses (HSV)-1 and -2 and varicella-zoster virus (VZV), and the Gammaherpesvirinae subfamily that includes Epstein–Barr virus.[4]

All herpesviruses share a characteristic ability to remain latent within the body over long periods. Although they may be found throughout the body, CMV infections are frequently associated with the salivary glands in humans and other mammals.[5] Other CMV viruses are found in several mammal species, but species isolated from animals differ from HCMV in terms of genomic structure, and have not been reported to cause human disease.


Group: dsDNA

Family: Herpesviridae
Sub-Family: Betaherpesvirinae
Genus: Cytomegalovirus
  • Aotine herpesvirus 1
  • Cebine herpesvirus 1
  • Cercopithecine herpesvirus 5
  • Human herpesvirus 5>
  • Macacine herpesvirus 3
  • Panine herpesvirus 2
  • Papiine herpesvirus 3
  • Saimiriine herpesvirus 4


Classified Cytomegaloviruses
Scientific Name Host Common Name

Human herpesvirus 5 (HHV-5)
Cercopithecine herpesvirus 5 (CeHV-5)
Cercopithecine herpesvirus 8 (CeHV-8)
Panine herpesvirus 2 (PoHV-2)
Pongine herpesvirus 4 (PoHV-4)
Aotine herpesvirus 1 (AoHV-1)—tentative classification
Aotine herpesvirus 3 (AoHV-3)—tentative classification

African green monkey
Rhesus monkey
Night monkey

Human CMV (HCMV)
Simian CMV (SCCMV)
Rhesus CMV (RhCMV)
Chimpanzee CMV (CCMV)
Herpesvirus aotus 1
Herpesvirus aotus 3

Several species of Cytomegalovirus have been identified and classified for different mammals.[5] The most studied is Human cytomegalovirus (HCMV), which is also known as Human herpesvirus 5 (HHV-5). Other primate CMV species include Chimpanzee cytomegalovirus (CCMV) that infects chimpanzees and orangutans, and Simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus (RhCMV) that infect macaques; CCMV is known as both Panine herpesvirus 2 (PaHV-2) and Pongine herpesvirus-4 (PoHV-4). SCCMV is called Cercopithecine herpesvirus-5 (CeHV-5) and RhCMV, Cercopithecine herpesvirus 8 (CeHV-8). A further two viruses found in the night monkey are tentatively placed in the Cytomegalovirus genus, and are called Herpesvirus aotus 1 and Herpesvirus aotus 3. Rodents also have viruses previously called cytomegaloviruses that are now reclassified under the genus Muromegalovirus; this genus contains Mouse cytomegalovirus (MCMV) is also known as Murid herpesvirus 1 (MuHV-1) and the closely related Murid herpesvirus 2 (MuHV-2) that is found in rats. In addition, there many other viral species with the name Cytomegalovirus identified in distinct mammals that are as yet not completely classified; these were predominantly isolated from primates and rodents.


Viruses in Cytomegalovirus are enveloped, with icosahedral, Spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 200kb in length.[2]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Cytomegalovirus Spherical Pleomorphic T=16 Enveloped Linear Monopartite

Life Cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, and budding. Human and monkeys serve as the natural host. Transmission routes are contact, urine, and saliva.[2]

Genus Host Details Tissue Tropism Entry Details Release Details Replication Site Assembly Site Transmission
Cytomegalovirus Humans; monkeys Epithelial mucosa Glycoprotiens Budding Nucleus Nucleus Urine; saliva

Genetic engineering

The CMV promoter is commonly included in vectors used in genetic engineering work conducted in mammalian cells, as it is a strong promoter and drives constitutive expression of genes under its control.[6]


  1. Mattes FM, McLaughlin JE, Emery VC, Clark DA, Griffiths PD (August 2000). "Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7". J. Clin. Pathol. 53 (8): 612–4. doi:10.1136/jcp.53.8.612. PMC 1762915. PMID 11002765.
  2. 2.0 2.1 2.2 "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
  4. 4.0 4.1 Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 556, 566–9. ISBN 0-8385-8529-9.
  5. 5.0 5.1 5.2 Koichi Yamanishi; Arvin, Ann M.; Gabriella Campadelli-Fiume; Edward Mocarski; Moore, Patrick; Roizman, Bernard; Whitley, Richard (2007). Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge, UK: Cambridge University Press. ISBN 0-521-82714-0.
  6. Kendall Morgan for Addgene Blog. Apr 3, 2014 Plasmids 101: The Promoter Region – Let's Go!

External Links

Template:Baltimore classification Template:Viral diseases