HAS3: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Hyaluronan synthase 3''' is an [[enzyme]] that in humans is encoded by the ''HAS3'' [[gene]].<ref name="pmid9169154">{{cite journal |vauthors=Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA | title = Chromosomal localization of the human and mouse hyaluronan synthase genes | journal = Genomics | volume = 41 | issue = 3 | pages = 493–7 |date=Jul 1997 | pmid = 9169154 | pmc =  | doi = 10.1006/geno.1997.4696 }}</ref><ref name="pmid9083017">{{cite journal |vauthors=Spicer AP, Olson JS, McDonald JA | title = Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase | journal = J Biol Chem | volume = 272 | issue = 14 | pages = 8957–61 |date=May 1997 | pmid = 9083017 | pmc =  | doi =10.1074/jbc.272.14.8957 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HAS3 hyaluronan synthase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3038| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hyaluronan synthase 3
| HGNCid = 4820
| Symbol = HAS3
| AltSymbols =;
| OMIM = 602428
| ECnumber =
| Homologene = 68461
| MGIid = 109599
  | Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0050501 |text = hyaluronan synthase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3038
    | Hs_Ensembl = ENSG00000103044
    | Hs_RefseqProtein = NP_005320
    | Hs_RefseqmRNA = NM_005329
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 67697661
    | Hs_GenLoc_end = 67710102
    | Hs_Uniprot = O00219
    | Mm_EntrezGene = 15118
    | Mm_Ensembl = ENSMUSG00000031910
    | Mm_RefseqmRNA = XM_994700
    | Mm_RefseqProtein = XP_999794
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 109763037
    | Mm_GenLoc_end = 109767957
    | Mm_Uniprot = Q8CEB9
  }}
}}
'''Hyaluronan synthase 3''', also known as '''HAS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HAS3 hyaluronan synthase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3038| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: HAS3 hyaluronan synthase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3038| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Spicer AP, Olson JS, McDonald JA |title=Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 8957-61 |year= 1997 |pmid= 9083017 |doi=  }}
*{{cite journal   |vauthors=Jacobson A, Brinck J, Briskin MJ, etal |title=Expression of human hyaluronan synthases in response to external stimuli. | series=348 |journal=Biochem. J. |volume=Pt 1 |issue=  1|pages= 29–35 |year= 2000 |pmid= 10794710 |doi=10.1042/0264-6021:3480029  | pmc=1221032 }}
*{{cite journal  | author=Spicer AP, Seldin MF, Olsen AS, ''et al.'' |title=Chromosomal localization of the human and mouse hyaluronan synthase genes. |journal=Genomics |volume=41 |issue= 3 |pages= 493-7 |year= 1997 |pmid= 9169154 |doi= 10.1006/geno.1997.4696 }}
*{{cite journal   |vauthors=Simpson MA, Reiland J, Burger SR, etal |title=Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17949–57 |year= 2001 |pmid= 11278609 |doi= 10.1074/jbc.M010064200 }}
*{{cite journal  | author=Jacobson A, Brinck J, Briskin MJ, ''et al.'' |title=Expression of human hyaluronan synthases in response to external stimuli. |journal=Biochem. J. |volume=348 Pt 1 |issue=  |pages= 29-35 |year= 2000 |pmid= 10794710 |doi=  }}
*{{cite journal  |vauthors=Kuroda K, Utani A, Hamasaki Y, Shinkai H |title=Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts. |journal=J. Dermatol. Sci. |volume=26 |issue= 2 |pages= 156–60 |year= 2001 |pmid= 11378333 |doi=10.1016/S0923-1811(00)00155-9 }}
*{{cite journal | author=Simpson MA, Reiland J, Burger SR, ''et al.'' |title=Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17949-57 |year= 2001 |pmid= 11278609 |doi= 10.1074/jbc.M010064200 }}
*{{cite journal   |vauthors=Liu N, Gao F, Han Z, etal |title=Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. |journal=Cancer Res. |volume=61 |issue= 13 |pages= 5207–14 |year= 2001 |pmid= 11431361 |doi=  }}
*{{cite journal  | author=Kuroda K, Utani A, Hamasaki Y, Shinkai H |title=Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts. |journal=J. Dermatol. Sci. |volume=26 |issue= 2 |pages= 156-60 |year= 2001 |pmid= 11378333 |doi=  }}
*{{cite journal   |vauthors=Simpson MA, Wilson CM, Furcht LT, etal |title=Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10050–7 |year= 2002 |pmid= 11790779 |doi= 10.1074/jbc.M110069200 }}
*{{cite journal | author=Liu N, Gao F, Han Z, ''et al.'' |title=Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. |journal=Cancer Res. |volume=61 |issue= 13 |pages= 5207-14 |year= 2001 |pmid= 11431361 |doi=  }}
*{{cite journal   |vauthors=Sayo T, Sugiyama Y, Takahashi Y, etal |title=Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. |journal=J. Invest. Dermatol. |volume=118 |issue= 1 |pages= 43–8 |year= 2002 |pmid= 11851874 |doi= 10.1046/j.0022-202x.2001.01613.x }}
*{{cite journal | author=Simpson MA, Wilson CM, Furcht LT, ''et al.'' |title=Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10050-7 |year= 2002 |pmid= 11790779 |doi= 10.1074/jbc.M110069200 }}
*{{cite journal   |vauthors=Chagnon P, Michaud J, Mitchell G, etal |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443–9 |year= 2003 |pmid= 12417987 |doi=10.1086/344580  | pmc=378590 }}
*{{cite journal | author=Sayo T, Sugiyama Y, Takahashi Y, ''et al.'' |title=Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. |journal=J. Invest. Dermatol. |volume=118 |issue= 1 |pages= 43-8 |year= 2002 |pmid= 11851874 |doi= 10.1046/j.0022-202x.2001.01613.x }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Chagnon P, Michaud J, Mitchell G, ''et al.'' |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443-9 |year= 2003 |pmid= 12417987 |doi=  }}
*{{cite journal   |vauthors=Bullard KM, Kim HR, Wheeler MA, etal |title=Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 739–46 |year= 2004 |pmid= 14566823 |doi= 10.1002/ijc.11475 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Suzuki K, Yamamoto T, Usui T, etal |title=Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. |journal=Jpn. J. Ophthalmol. |volume=47 |issue= 6 |pages= 557–64 |year= 2004 |pmid= 14636845 |doi=10.1016/j.jjo.2003.09.001 }}
*{{cite journal | author=Bullard KM, Kim HR, Wheeler MA, ''et al.'' |title=Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 739-46 |year= 2004 |pmid= 14566823 |doi= 10.1002/ijc.11475 }}
*{{cite journal  |vauthors=Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM |title=Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells. |journal=Biochim. Biophys. Acta |volume=1760 |issue= 6 |pages= 890–5 |year= 2006 |pmid= 16564133 |doi= 10.1016/j.bbagen.2006.02.002 }}
*{{cite journal | author=Suzuki K, Yamamoto T, Usui T, ''et al.'' |title=Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. |journal=Jpn. J. Ophthalmol. |volume=47 |issue= 6 |pages= 557-64 |year= 2004 |pmid= 14636845 |doi=  }}
*{{cite journal   |vauthors=Campo GM, Avenoso A, Campo S, etal |title=TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate. |journal=Mol. Cell. Biochem. |volume=292 |issue= 1-2 |pages= 169–78 |year= 2007 |pmid= 16786194 |doi= 10.1007/s11010-006-9230-7 }}
*{{cite journal  | author=Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM |title=Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells. |journal=Biochim. Biophys. Acta |volume=1760 |issue= 6 |pages= 890-5 |year= 2006 |pmid= 16564133 |doi= 10.1016/j.bbagen.2006.02.002 }}
*{{cite journal | author=Campo GM, Avenoso A, Campo S, ''et al.'' |title=TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate. |journal=Mol. Cell. Biochem. |volume=292 |issue= 1-2 |pages= 169-78 |year= 2007 |pmid= 16786194 |doi= 10.1007/s11010-006-9230-7 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Glycosyltransferases}}
{{WikiDoc Sources}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-16-stub}}

Latest revision as of 13:27, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[1][2][3]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
  2. ↑ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.
  3. ↑ 3.0 3.1 "Entrez Gene: HAS3 hyaluronan synthase 3".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=HAS3&oldid=1417405"