HAS3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[1][2][3]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
  2. Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.
  3. 3.0 3.1 "Entrez Gene: HAS3 hyaluronan synthase 3".

Further reading




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