UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10gene.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
van Es HH, Bout A, Liu J, et al. (1993). "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37". Cytogenet. Cell Genet. 63 (2): 114–6. doi:10.1159/000133513. PMID8467709.
Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue". Mol. Pharmacol. 52 (2): 212–20. PMID9271343.
Mojarrabi B, Mackenzie PI (1998). "Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon". Biochem. Biophys. Res. Commun. 247 (3): 704–9. doi:10.1006/bbrc.1998.8843. PMID9647757.
Cheng Z, Radominska-Pandya A, Tephly TR (1999). "Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10". Drug Metab. Dispos. 27 (10): 1165–70. PMID10497143.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID10748067.
Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues". Drug Metab. Dispos. 30 (4): 397–403. doi:10.1124/dmd.30.4.397. PMID11901093.
Jinno H, Saeki M, Tanaka-Kagawa T, et al. (2003). "Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10". Drug Metab. Dispos. 31 (5): 528–32. doi:10.1124/dmd.31.5.528. PMID12695339.