Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase

Jump to: navigation, search

In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122) is an enzyme that catalyzes the chemical reaction

UDP-galactose + glycoprotein N-acetyl-D-galactosamine UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine

Thus, the two substrates of this enzyme are UDP-galactose and glycoprotein N-acetyl-D-galactosamine, whereas its two products are UDP and glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase. This enzyme is also called uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

References

  • IUBMB entry for 2.4.1.122
  • BRENDA references for 2.4.1.122 (Recommended.)
  • PubMed references for 2.4.1.122
  • PubMed Central references for 2.4.1.122
  • Google Scholar references for 2.4.1.122
  • Hesford FJ, Berger EG, Van den Eijnden DH (1981). "Identification of the product formed by human erythrocyte galactosyltransferase". Biochim. Biophys. Acta. 659: 302&ndash, 11. PMID 6789880.
  • Mendicino J, Sivakami S, Davila M, Chandrasekaran EV (1982). "Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa". J. Biol. Chem. 257: 3987&ndash, 94. PMID 6801057.
  • Schachter H, Narasimhan S, Gleeson P, Vella G (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods. Enzymol. 98: 98&ndash, 134. PMID 6366476.

External links

The CAS registry number for this enzyme class is 97089-61-7.

Gene Ontology (GO) codes


Linked-in.jpg