Monosialoganglioside sialyltransferase

Jump to: navigation, search

In enzymology, a monosialoganglioside sialyltransferase (EC 2.4.99.2) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide CMP + N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide

The 3 substrates of this enzyme are CMP-N-acetylneuraminate, D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-, and galactosyl-D-glucosylceramide, whereas its 3 products are CMP, N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-, and acetylneuraminyl)-D-galactosyl-D-glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-ac etylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase.

References

  • IUBMB entry for 2.4.99.2
  • BRENDA references for 2.4.99.2 (Recommended.)
  • PubMed references for 2.4.99.2
  • PubMed Central references for 2.4.99.2
  • Google Scholar references for 2.4.99.2
  • Rearick JI, Sadler JE, Paulson JC, Hill RL (1979). "Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland". J. Biol. Chem. 254: 4444&ndash, 51. PMID 438198.
  • Yip MC (1973). "The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: monosialoganglioside (G M1 ) sialyltransferase". Biochim. Biophys. Acta. 306: 298&ndash, 306. PMID 4351506.

External links

The CAS registry number for this enzyme class is 60202-12-2.

Gene Ontology (GO) codes


Linked-in.jpg