Thrombus
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A thrombus, or blood clot, is the final product of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system (i.e. clotting factors). A thrombus is physiologic in cases of injury, but pathologic in case of thrombosis.
Specifically, a thrombus is a blood clot in an intact blood vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel. In a small blood vessel, blood flow may be completely cut-off resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is an embolus.
Some of the conditions which elevate risk of blood clots developing include atrial fibrillation (a form of cardiac arrhythmia), heart valve replacement, a recent heart attack, extended periods of inactivity (see deep venous thrombosis), and genetic or disease-related deficiencies in the blood's clotting abilities.
Preventing blood clots reduces the risk of stroke, heart attack and pulmonary embolism. Heparin and warfarin are often used to inhibit the formation and growth of existing blood clots, thereby allowing the body to shrink and dissolve the blood clots through normal methods (see anticoagulant).
A thrombus differs from a hematoma by:
- Having high hematocrit
- Being non-laminar
- Being soft and friable
- Having an absence of circulation
Virchow's Triad describes the conditions necessary for thrombus formation:
- Changes in vessel wall morphology (e.g. trauma, atheroma)
- Changes in blood flow through the vessel (e.g. valvulitis, aneurysm)
- Changes in blood composition (e.g. leukaemia, hypercoagulability disorders)
Disseminated intravascular coagulation (DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and fibrinolysis using all of the body's available platelets and clotting factors. The end result is ischaemic necrosis of the affected tissue/organs and spontaneous bleeding due to the lack of clotting factors. Causes are septicaemia, acute leukaemia, shock, snake bites or severe trauma. Treatment involves the use of fresh, frozen plasma to restore the level of clotting factors in the blood.
See also
- Air pollution
- Embolism
- Thrombolysis ("Destruction of clot")
- Thrombogenicity (the tendency to clot)
External links
- Treatment and Symptoms of Blood Clots -- Med-Help.net, Medical Information Resource, 1999
- North American Thrombosis Forum - NATF is a nonprofit organization that aims to promote public education, policy and advocacy for clotting diseases of the cardiovascular system.
- Air Pollution Triggers Blood Clots - US Study
- Cleveland Clinic Web Chat - Blood Clots, Hypercoagulable States, DVT with Dr. John Bartholomew
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
