Nonspecific ST-segment and T-wave changes

Schematic representation of normal ECG segments

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Synonyms and keywords: NSSTW changes

Overview

Non specific ST T wave changes refer to changes in the T waves (such as inversion or flattening) and ST segments (such as ST depression) on the electrocardiogram that due not follow an anatomic distribution and are not diagnostic of any one condition.

Causes of Non Specific ST Segment and T Wave Changes

• Adrenal insufficiency
• Anxiety
• Central nervous system diseases
• Congestive heart failure
• Digoxin
• Electrolyte disturbances
• Gallbladder disease
• Heart failure
• Hyperkalemia
• Hyperventilation (in 70% of patients after 30 to 60 seconds)
• Hypokalemia
• Hypopituitarism
• Hypothyroidism
• Ischemic heart disease
• Left ventricular hypertrophy (LVH)
• Mitral valve prolapse (MVP)
• Orthostatic changes (3 to 23%), most prominent in the inferior leads
• Pacemaker
• Pancreatitis
• Pheochromocytoma
• Postprandial T-waves changes
• Pulmonary embolism
• Pericarditis
• Right ventricular hypertrophy (RVH)
• Truncal vagotomy