P-type calcium channel
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| calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
| |
| Identifiers | |
| Symbol | CACNA1A |
| Alt. Symbols | CACNL1A4, SCA6, MHP1, MHP |
| Entrez | 773 |
| HUGO | 1388 |
| OMIM | 601011 |
| RefSeq | NM_000068 |
| UniProt | O00555 |
| Other data | |
| Locus | Chr. 19 p13 |
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The p-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
P-type ('P' for cerebellar Purkinje cells) calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic terminal, and in neuronal integration in many neuronal types.
They are also found in Purkinje fibers in the electrical conduction system of the heart. Their properties are less well understood.
P channels were discovered in cerebellar Purkinje cells by Llinas and Sugimori[1] and named P channels by Llinas et al.[1]
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
