Funny current
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
|
WikiDoc Resources for Funny current | |
|
Articles | |
|---|---|
|
Most recent articles on Funny current Most cited articles on Funny current | |
|
Media | |
|
Powerpoint slides on Funny current | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Funny current at Clinical Trials.gov Trial results on Funny current Clinical Trials on Funny current at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Funny current NICE Guidance on Funny current
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Funny current Discussion groups on Funny current Patient Handouts on Funny current Directions to Hospitals Treating Funny current Risk calculators and risk factors for Funny current
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Funny current | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Business | |
|
Experimental / Informatics | |
| Cardiology Network |
 Discuss Funny current further in the WikiDoc Cardiology Network |
| Adult Congenital |
|---|
| Biomarkers |
| Cardiac Rehabilitation |
| Congestive Heart Failure |
| CT Angiography |
| Echocardiography |
| Electrophysiology |
| Cardiology General |
| Genetics |
| Health Economics |
| Hypertension |
| Interventional Cardiology |
| MRI |
| Nuclear Cardiology |
| Peripheral Arterial Disease |
| Prevention |
| Public Policy |
| Pulmonary Embolism |
| Stable Angina |
| Valvular Heart Disease |
| Vascular Medicine |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Funny current (or funny channel, or If) refers to a specific current in the heart. It is called "funny" because it has effects opposite to those of most other heart currents.
If is a mixed Na+–K+ inward current activated by hyperpolarization and modulated by the autonomic nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the sinoatrial (SA) node.
Most channels are activated through depolarization, but in the SA node and AV node, the channel becomes activated through hyperpolarization, at approximately -40mV.
Funny currents have been associated with cyclic-nucleotide-gated channels.[1]
Clinical significance
Drugs such as ivabradine are intended to inhibit the funny current, and thus slow down the heart rate. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner.
See also
References
- ↑ DiFrancesco D (2006). "Serious workings of the funny current". Prog. Biophys. Mol. Biol. 90 (1-3): 13-25. doi:10.1016/j.pbiomolbio.2005.05.001. PMID 15975637.
External links
- Accili E, Proenza C, Baruscotti M, DiFrancesco D. "From funny current to HCN channels: 20 years of excitation.". News Physiol Sci 17: 32-7. PMID 11821534.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
