SK channel
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Small conductance (SK) calcium-activated potassium channels are a type of Ca2+-activated K+ channels. SK channels, apparently voltage insensitive, are gated by submicromolar-levels of intracellular Ca2+ ions and are important for regulating afterhyperpolarization in central neurones and other cell types.
SK channels are thought to be involved in synaptic plasticity and can be pharmacologically blocked by a plant-derived neurotoxin Bicuculline
The SK channel family contains 3 members - Sk1, SK2 and SK3.
All cloned SK channels, SK1, SK2 and SK3 are sensitive to the bee venom apamin and the scorpion venom tamapin.
Several SK channel family subunits were cloned (See for example Dr. John Adelman http://www.ohsu.edu/vollum/faculty/adelman/
Classification
- Kca2.x : Kca2.1 (KCNN1), Kca2.2 (KCNN2), Kca2.3 (KCNN3)
- Kca3.x: Kca3.1 (KCNN4)
- Kca4.x: Kca4.1 (KCNT1), Kca4.2 (KCNT2)
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

