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Small conductance (SK) calcium-activated potassium channels are a type of Ca2+-activated K+ channels. SK channels, apparently voltage insensitive, are gated by submicromolar-levels of intracellular Ca2+ ions and are important for regulating afterhyperpolarization in central neurones and other cell types.
The SK channel family contains 3 members - Sk1, SK2 and SK3.
Several SK channel family subunits were cloned (See for example Dr. John Adelman http://www.ohsu.edu/vollum/faculty/adelman/
- Kca2.x : Kca2.1 (KCNN1), Kca2.2 (KCNN2), Kca2.3 (KCNN3)
- Kca3.x: Kca3.1 (KCNN4)
- Kca4.x: Kca4.1 (KCNT1), Kca4.2 (KCNT2)
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