ACCN2

Amiloride-sensitive cation channel 2, neuronal
Identifiers
Symbols	ACCN2 ; ASIC; ASIC1A; BNaC2; hBNaC2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37440
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amiloride-sensitive cation channel 2, neuronal, also known as ACCN2, is a human gene.

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.

Further reading

• Corey DP, García-Añoveros J (1996). "Mechanosensation and the DEG/ENaC ion channels". Science. 273 (5273): 323–4. PMID 8685718.
• García-Añoveros J, Derfler B, Neville-Golden J; et al. (1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1459–64. PMID 9037075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waldmann R, Champigny G, Bassilana F; et al. (1997). "A proton-gated cation channel involved in acid-sensing". Nature. 386 (6621): 173–7. doi:10.1038/386173a0. PMID 9062189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bassilana F, Champigny G, Waldmann R; et al. (1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties". J. Biol. Chem. 272 (46): 28819–22. PMID 9360943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bubien JK, Keeton DA, Fuller CM; et al. (1999). "Malignant human gliomas express an amiloride-sensitive Na+ conductance". Am. J. Physiol. 276 (6 Pt 1): C1405–10. PMID 10362604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Askwith CC, Cheng C, Ikuma M; et al. (2000). "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels". Neuron. 26 (1): 133–41. PMID 10798398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bässler EL, Ngo-Anh TJ, Geisler HS; et al. (2001). "Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b". J. Biol. Chem. 276 (36): 33782–7. doi:10.1074/jbc.M104030200. PMID 11448963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). "Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells". Pflugers Arch. 442 (5): 668–74. PMID 11512022.CS1 maint: Multiple names: authors list (link)
• Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.CS1 maint: Multiple names: authors list (link)
• Ji HL, Jovov B, Fu J; et al. (2002). "Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes". J. Biol. Chem. 277 (10): 8395–405. doi:10.1074/jbc.M109465200. PMID 11748227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. PMID 11802773.CS1 maint: Multiple names: authors list (link)
• Wemmie JA, Chen J, Askwith CC; et al. (2002). "The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory". Neuron. 34 (3): 463–77. PMID 11988176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berdiev BK, Xia J, Jovov B; et al. (2003). "Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function". J. Biol. Chem. 277 (48): 45734–40. doi:10.1074/jbc.M208995200. PMID 12244121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ugawa S, Ueda T, Ishida Y; et al. (2002). "Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors". J. Clin. Invest. 110 (8): 1185–90. PMID 12393854.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonard AS, Yermolaieva O, Hruska-Hageman A; et al. (2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMID 12578970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wemmie JA, Coryell MW, Askwith CC; et al. (2004). "Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3621–6. doi:10.1073/pnas.0308753101. PMID 14988500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poirot O, Vukicevic M, Boesch A, Kellenberger S (2004). "Selective regulation of acid-sensing ion channel 1 by serine proteases". J. Biol. Chem. 279 (37): 38448–57. doi:10.1074/jbc.M407381200. PMID 15247234.CS1 maint: Multiple names: authors list (link)
• Price MP, Thompson RJ, Eshcol JO; et al. (2005). "Stomatin modulates gating of acid-sensing ion channels". J. Biol. Chem. 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)