AQP7

Aquaporin 7
Identifiers
Symbol(s)	AQP7; AQP7L; AQP9; AQPap; MGC149555; MGC149556
External IDs	OMIM: 602974 MGI: 1314647 Homologene: 48000
Gene ontology Molecular Function: • transporter activity • water channel activity • glycerol channel activity • porin activity Cellular Component: • integral to plasma membrane • membrane • integral to membrane • outer membrane Biological Process: • generation of precursor metabolites and energy • transport • water transport • excretion • glycerol transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	364	11832
Ensembl	ENSG00000165269	ENSMUSG00000028427
Uniprot	O14520	Q5DX24
Refseq	NM_001170 (mRNA) NP_001161 (protein)	XM_982564 (mRNA) XP_987658 (protein)
Location	Chr 9: 33.37 - 33.39 Mb	Chr 4: 41.22 - 41.24 Mb
Pubmed search	[1]	[2]

Aquaporin 7, also known as AQP7, is a human gene.

Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.

See also

• Aquaporin

Further reading

• Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport.". Proc. Soc. Exp. Biol. Med. 219 (3): 183-99. PMID 9824541.
• Ishibashi K, Kuwahara M, Gu Y, et al. (1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.". J. Biol. Chem. 272 (33): 20782-6. PMID 9252401.
• Kuriyama H, Kawamoto S, Ishida N, et al. (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.". Biochem. Biophys. Res. Commun. 241 (1): 53-8. doi:10.1006/bbrc.1997.7769. PMID 9405233.
• Ishibashi K, Yamauchi K, Kageyama Y, et al. (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.". Biochim. Biophys. Acta 1399 (1): 62-6. PMID 9714739.
• Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.". Cell Tissue Res. 295 (2): 279-85. PMID 9931374.
• Kondo H, Shimomura I, Kishida K, et al. (2002). "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.". Eur. J. Biochem. 269 (7): 1814-26. PMID 11952783.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
• Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers.". Biochem. Biophys. Res. Commun. 339 (3): 785-9. doi:10.1016/j.bbrc.2005.11.080. PMID 16325777.
• Prudente S, Flex E, Morini E, et al. (2007). "A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.". Diabetes 56 (5): 1468-74. doi:10.2337/db06-1389. PMID 17351148.
• Ceperuelo-Mallafré V, Miranda M, Chacón MR, et al. (2007). "Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes.". J. Clin. Endocrinol. Metab. 92 (9): 3640-5. doi:10.1210/jc.2007-0531. PMID 17566090.

External links

• MeSH AQP7+protein,+human

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.