CLCN2

Chloride channel 2
Identifiers
Symbol(s)	CLCN2; CIC-2; CLC2; ECA3; EGI3; EGMA
External IDs	OMIM: 600570 MGI: 105061 Homologene: 3213
Gene ontology Molecular Function: • voltage-gated chloride channel activity • chloride ion binding Cellular Component: • membrane fraction • integral to plasma membrane • membrane Biological Process: • ion transport • chloride transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1181	12724
Ensembl	ENSG00000114859	ENSMUSG00000022843
Uniprot	P51788	Q0VBC2
Refseq	NM_004366 (mRNA) NP_004357 (protein)	NM_009900 (mRNA) NP_034030 (protein)
Location	Chr 3: 185.55 - 185.56 Mb	Chr 16: 20.62 - 20.63 Mb
Pubmed search	[1]	[2]

Chloride channel 2, also known as CLCN2, is a human gene.

Further reading

• Cid LP, Montrose-Rafizadeh C, Smith DI, et al. (1995). "Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues.". Hum. Mol. Genet. 4 (3): 407-13. PMID 7795595.
• Lamb FS, Clayton GH, Liu BX, et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels.". J. Mol. Cell. Cardiol. 31 (3): 657-66. doi:10.1006/jmcc.1998.0901. PMID 10198195.
• Sander T, Schulz H, Saar K, et al. (2000). "Genome search for susceptibility loci of common idiopathic generalised epilepsies.". Hum. Mol. Genet. 9 (10): 1465-72. PMID 10888596.
• Lamb FS, Graeff RW, Clayton GH, et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.". Am. J. Respir. Cell Mol. Biol. 24 (4): 376-81. PMID 11306429.
• Lipecka J, Bali M, Thomas A, et al. (2002). "Distribution of ClC-2 chloride channel in rat and human epithelial tissues.". Am. J. Physiol., Cell Physiol. 282 (4): C805-16. doi:10.1152/ajpcell.00291.2001. PMID 11880269.
• Nehrke K, Arreola J, Nguyen HV, et al. (2002). "Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice.". J. Biol. Chem. 277 (26): 23604-11. doi:10.1074/jbc.M202900200. PMID 11976342.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex.". J. Biol. Chem. 278 (18): 16262-70. doi:10.1074/jbc.M209828200. PMID 12601004.
• Haug K, Warnstedt M, Alekov AK, et al. (2003). "Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies.". Nat. Genet. 33 (4): 527-32. doi:10.1038/ng1121. PMID 12612585.
• Olsen ML, Schade S, Lyons SA, et al. (2003). "Expression of voltage-gated chloride channels in human glioma cells.". J. Neurosci. 23 (13): 5572-82. PMID 12843258.
• Cuppoletti J, Tewari KP, Sherry AM, et al. (2004). "Sites of protein kinase A activation of the human ClC-2 Cl(-) channel.". J. Biol. Chem. 279 (21): 21849-56. doi:10.1074/jbc.M312567200. PMID 15010473.
• Niemeyer MI, Yusef YR, Cornejo I, et al. (2005). "Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies.". Physiol. Genomics 19 (1): 74-83. doi:10.1152/physiolgenomics.00070.2004. PMID 15252188.
• Huber SM, Duranton C, Henke G, et al. (2004). "Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte.". J. Biol. Chem. 279 (40): 41444-52. doi:10.1074/jbc.M407618200. PMID 15272009.
• Hori K, Takahashi Y, Horikawa N, et al. (2004). "Is the ClC-2 chloride channel involved in the Cl- secretory mechanism of gastric parietal cells?". FEBS Lett. 575 (1-3): 105-8. doi:10.1016/j.febslet.2004.08.044. PMID 15388342.
• Chu S, Blaisdell CJ, Bamford P, Ferro TJ (2004). "Interferon-gamma regulates ClC-2 chloride channel in lung epithelial cells.". Biochem. Biophys. Res. Commun. 324 (1): 31-9. doi:10.1016/j.bbrc.2004.09.026. PMID 15464978.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• D'Agostino D, Bertelli M, Gallo S, et al. (2006). "Mutations and polymorphisms of the CLCN2 gene in idiopathic epilepsy.". Neurology 63 (8): 1500-2. PMID 15505175.
• Blaisdell CJ, Howard TD, Stern A, et al. (2004). "CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity.". BMC Med. Genet. 5: 26. doi:10.1186/1471-2350-5-26. PMID 15507145.
• Heils A (2004). "CLCN2 and idiopathic generalized epilepsy.". Advances in neurology 95: 265-71. PMID 15508929.
• Hinzpeter A, Lipecka J, Brouillard F, et al. (2006). "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function.". Am. J. Physiol., Cell Physiol. 290 (1): C45-56. doi:10.1152/ajpcell.00209.2005. PMID 16049054.