Gabapentin

Synonyms / Brand Names: Neurontin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

Gabapentin is given orally with or without food. Half-tablets not used within several days of breaking the scored tablet should be discarded.

Postherpetic Neuralgia: a single 300-mg dose on Day 1, 600 mg/day on Day 2 (divided BID), and 900 mg/day on Day 3 (divided TID). The dose can subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID).

Epilepsy: For age 12+, 900 to 1800 mg/day in divided dosage, starting at 300mg TID. For ages 3-12, 10–15 mg/kg/day in 3 divided doses, and the effective dose reached by increasing over 3 days. (effective dose for age 5+:25–35 mg/kg/day divided TID; age 3-4: 40 mg/kg/day divided TID)

Dosage in the elderly:Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients.

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Calculate Creatine Clearance
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