Creatinine clearance

Jump to: navigation, search

WikiDoc Resources for Creatinine clearance


Most recent articles on Creatinine clearance

Most cited articles on Creatinine clearance

Review articles on Creatinine clearance

Articles on Creatinine clearance in N Eng J Med, Lancet, BMJ


Powerpoint slides on Creatinine clearance

Images of Creatinine clearance

Photos of Creatinine clearance

Podcasts & MP3s on Creatinine clearance

Videos on Creatinine clearance

Evidence Based Medicine

Cochrane Collaboration on Creatinine clearance

Bandolier on Creatinine clearance

TRIP on Creatinine clearance

Clinical Trials

Ongoing Trials on Creatinine clearance at Clinical

Trial results on Creatinine clearance

Clinical Trials on Creatinine clearance at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Creatinine clearance

NICE Guidance on Creatinine clearance


FDA on Creatinine clearance

CDC on Creatinine clearance


Books on Creatinine clearance


Creatinine clearance in the news

Be alerted to news on Creatinine clearance

News trends on Creatinine clearance


Blogs on Creatinine clearance


Definitions of Creatinine clearance

Patient Resources / Community

Patient resources on Creatinine clearance

Discussion groups on Creatinine clearance

Patient Handouts on Creatinine clearance

Directions to Hospitals Treating Creatinine clearance

Risk calculators and risk factors for Creatinine clearance

Healthcare Provider Resources

Symptoms of Creatinine clearance

Causes & Risk Factors for Creatinine clearance

Diagnostic studies for Creatinine clearance

Treatment of Creatinine clearance

Continuing Medical Education (CME)

CME Programs on Creatinine clearance


Creatinine clearance en Espanol

Creatinine clearance en Francais


Creatinine clearance in the Marketplace

Patents on Creatinine clearance

Experimental / Informatics

List of terms related to Creatinine clearance

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


In general, creatinine clearance is the removal of creatinine from the body. In renal physiology, creatinine clearance (CCr) is the volume of blood plasma that is cleared of creatinine per unit time. Clinically, creatinine clearance is a useful measure for estimating the glomerular filtration rate (GFR) of the kidneys.

Use in estimating GFR

Glomerular filtration rate (GFR) can be calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys.

Creatinine is used because it fulfills these requirements (though not perfectly) and it is produced naturally by the body (creatinine is a metabolite of creatine, which is found in muscle). It is actively secreted by the kidneys such that creatinine clearance overestimates actual GFR by 10-20%. This margin of error is acceptable considering the ease with which creatinine clearance is measured. Other more precise GFR measurements involve constant infusions of inulin or another compound, to maintain a steady state in the blood. Since creatinine is already at a steady-state concentration in the blood, measuring creatinine clearance is much less cumbersome.

The result of this test is an important gauge used in assessing excretory function of the kidneys. For example grading of chronic renal insufficiency and dosage of drugs that are primarily excreted via urine are based on GFR (creatinine clearance).

It is commonly believed to be the amount of liquid filtered out of the blood that gets processed by the kidneys. Physiologically, these quantities (volumetric blood flow and mass removal) are only related loosely. Clearance is a ratio of the mass generation and concentration at a steady state.


Creatinine clearance (CCr) can be calculated if values for creatinine's urine concentration (UCr), urine flow rate (V), and creatinine's plasma concentration (PCr) are known. Since the product of urine concentration and urine flow rate yields creatine's excretion rate, creatinine clearance is also said to be its excretion rate (UCr×V) divided by its plasma concentration. This is commonly represented mathematically as

For example, a normal individual with a plasma creatinine concentration of 1 mg/dL, urine creatinine concentration of 60 mg/dL, and urine flow rate of 0.5 dL/h, would have a creatinine clearance given by

which yields 30 dL/h. Thus, 30 dL of blood are cleared of creatinine per hour.

Cockcroft-Gault approximation

More often, the creatinine clearance is estimated using the Cockcroft-Gault formula:

In some countries mmol/L is used instead of mg/dL. This change of units results in the following equation:

An online Cockcroft-Gault calculator is at


  • Creatinine clearance is the measure of the clearance of endogenous creatinine
  • Creatinine clearance is used for evaluating the glomerular filtration rate (GFR)
  • Reference range: 50-140 ml/min

CrCl in Evaluating Disease States

Influencing Factors

Differential Diagnosis



Related Chapters


nl:Kreatinineklaring ratio